Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

scientific article

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.47.10.3222-3232.2003
P932PMC publication ID201150
P698PubMed publication ID14506034

P50authorDiarmaid HughesQ38543763
P2093author name stringPatricia Komp Lindgren
Asa Karlsson
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Mutations of Bacteria from Virus Sensitivity to Virus ResistanceQ24533278
The complete genome sequence of Escherichia coli K-12Q27860542
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coliQ28144457
Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistanceQ29395941
Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activityQ33690598
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.Q33695982
Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coliQ33698034
The mar regulon: multiple resistance to antibiotics and other toxic chemicalsQ33739371
Molecular mechanisms that confer antibacterial drug resistanceQ33915635
Rapid and simple determination of the Escherichia coli phylogenetic groupQ33919655
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coliQ33979064
Cloning and nucleotide sequence of the DNA gyrase (gyrA) gene from Mycoplasma hominis and characterization of quinolone-resistant mutants selected in vitro with trovafloxacinQ33980747
Increasing resistance to fluoroquinolones in escherichia coli from urinary tract infections in the netherlandsQ40753468
A prospective study of risk factors for symptomatic urinary tract infection in young women.Q44808632
Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coliQ46102812
Homologous recombination between the tuf genes of Salmonella typhimurium.Q47826625
High mutation frequencies among Escherichia coli and Salmonella pathogensQ48057867
Mutator dynamics in fluctuating environments.Q52043835
Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli.Q52247046
The ECO.SENS Project: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens--interim report.Q53331404
Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli.Q53939108
Survey on antibiotic usage in the treatment of urinary tract infections.Q54032265
Quinolone resistance from a transferable plasmid.Q54143628
A close correlation between improvement of organic solvent tolerance levels and alteration of resistance toward low levels of multiple antibiotics in Escherichia coli.Q54181140
Role of mutator alleles in adaptive evolution.Q54564129
Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutQ56944626
Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliQ56944671
Mechanisms of fluoroquinolone resistanceQ74371163
Molecular analysis of fluoroquinolone-resistance in Escherichia coli on the aspect of gyrase and multiple antibiotic resistance (mar) genesQ74654645
Analysis of the mutations involved in fluoroquinolone resistance of in vivo and in vitro mutants of Escherichia coliQ78166633
Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutationsQ33982113
Pathogenesis of urinary tract infections: an updateQ34070526
Treatment options for acute uncomplicated cystitis in adultsQ34070531
Mutator bacteria as a risk factor in treatment of infectious diseasesQ34113782
An international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the ECO.SENS ProjectQ34166158
Regulation of bacterial drug export systemsQ34300836
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutantsQ34370243
The rise and fall of mutator bacteria.Q34392588
High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.Q34508854
Prevalence of plasmid-mediated quinolone resistanceQ34823435
Adverse drug reactions: implications for the development of fluoroquinolonesQ35110233
Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.Q35123629
Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli.Q35125674
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.Q35128319
Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.Q35131579
Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniaeQ35136293
Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.Q35138349
Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coliQ35605343
Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coliQ35631010
Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitroQ35821472
Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxBQ35836816
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coliQ36223906
Regulation of production of type 1 pili among urinary tract isolates of Escherichia coliQ37013735
Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.Q39471404
In vivo increase in resistance to ciprofloxacin in Escherichia coli associated with deletion of the C-terminal part of MarRQ39474394
Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinoloneQ39477158
Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.Q39477234
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining regionQ39478070
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.Q39559340
High frequency of mutator strains among human uropathogenic Escherichia coli isolates.Q39694657
Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC geneQ39781656
Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coliQ39801923
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliQ39816339
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coliQ40087129
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)3222-3232
P577publication date2003-10-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleMutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections
P478volume47

Reverse relations

cites work (P2860)
Q41881440'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites
Q28551202A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics
Q38966188A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants
Q64122917A one health perspective on dairy production and dairy food safety
Q36836273Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis
Q33805682Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones
Q37704177Antibiotic resistance and its cost: is it possible to reverse resistance?
Q21144279Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America
Q52360303Antimicrobial resistance (AMR) nanomachines-mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation.
Q36264490Antimicrobial resistance in the hospital setting: impact, trends, and infection control measures
Q37356533Antimicrobial resistance: its emergence and transmission
Q37263765Association of fluoroquinolone resistance, virulence genes, and IncF plasmids with extended-spectrum-β-lactamase-producing Escherichia coli sequence type 131 (ST131) and ST405 clonal groups.
Q27008535Bacterial Responses and Genome Instability Induced by Subinhibitory Concentrations of Antibiotics
Q33836664Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
Q37894832Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
Q47897914Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.
Q36905565Causes and consequences of DNA repair activity modulation during stationary phase in Escherichia coli
Q92051378Characterization of Mechanisms Lowering Susceptibility to Flumequine among Bacteria Isolated from Chilean Salmonid Farms
Q37157491Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China.
Q49841193Chromosomal mutations that accompany qnr in clinical isolates of escherichia coli
Q34104262Ciprofloxacin dosage and emergence of resistance in human commensal bacteria
Q54298880Ciprofloxacin resistance in E. coli isolated from turkeys in Great Britain.
Q46832047Comparison of the minimum inhibitory, mutant prevention and minimum bactericidal concentrations of ciprofloxacin, levofloxacin and garenoxacin against enteric Gram-negative urinary tract infection pathogens
Q37696851Compensation of fitness costs and reversibility of antibiotic resistance mutations
Q58756032Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
Q41810485Contribution of a new mutation in parE to quinolone resistance in extended-spectrum-beta-lactamase-producing Escherichia coli isolates
Q39674302Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae
Q36444536Contributions of mutations in acrR and marR genes to organic solvent tolerance in Escherichia coli
Q36295431Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli
Q36961674Controlling mutation: intervening in evolution as a therapeutic strategy
Q34487416Correlation of overexpression of efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients
Q28082095Costs of antibiotic resistance - separating trait effects and selective effects
Q36080959De Novo Characterization of Genes That Contribute to High-Level Ciprofloxacin Resistance in Escherichia coli
Q89907735Detection of Chromosomal and Plasmid-Mediated Quinolone Resistance Among Escherichia coli Isolated from Urinary Tract Infection Cases; Zagazig University Hospitals, Egypt
Q96022501Development and selection of low-level multi-drug resistance over an extended range of sub-inhibitory ciprofloxacin concentrations in Escherichia coli
Q40148534Digital PCR for Detection and Quantification of Fluoroquinolone Resistance in Legionella pneumophila.
Q43101882Draft Genome Sequences of Two Drug-Resistant Isolates of Pseudomonas aeruginosa Obtained from Keratitis Patients in India
Q38028573Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance
Q54340974Editorial comment to genome-wide transcriptome analysis of fluoroquinolone resistance in clinical isolates of Escherichia coli.
Q43503778Effect of six fluoroquinolones on the expression of four efflux pumps in the multidrug resistant Escherichia coli isolates
Q40164392Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital
Q33556074Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe
Q35023326Endocarditis caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility
Q39195574Environmental and genetic modulation of the phenotypic expression of antibiotic resistance
Q41624662Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China
Q37039694Epigenetic Influence of Dam Methylation on Gene Expression and Attachment in Uropathogenic Escherichia coli
Q28238561Evolution of mutation rates in bacteria
Q38543385Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms
Q45737750Expression of TolC and Organic Solvent Tolerance of Escherichia Coli Ciprofloxacin Resistant Mutants
Q37494961Factors affecting the reversal of antimicrobial-drug resistance.
Q47725174Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
Q46921856Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1.
Q36871802Fluoroquinolone resistance mechanisms in an Escherichia coli isolate, HUE1, without quinolone resistance-determining region mutations
Q43062855Fluoroquinolone resistance mechanisms in multidrug-resistant Escherichia coli isolated from extraintestinal infections in dogs.
Q33910855Fluoroquinolone resistance mechanisms of Shigella flexneri isolated in Bangladesh.
Q33225318Fluoroquinolone-resistant Escherichia coli, Indonesia
Q39990097Fosfomycin and rifampin disk diffusion tests for detection of Escherichia coli mutator strains
Q95840911Genes and Proteomes Associated With Increased Mutation Frequency and Multidrug Resistance of Naturally Occurring Mismatch Repair-Deficient Salmonella Hypermutators
Q90574301Genetic Characterization of Antimicrobial-Resistant Escherichia coli Isolated from a Mixed-Use Watershed in Northeast Georgia, USA
Q43167548Genetic profiles of fluoroquinolone-resistant Escherichia coli isolates obtained from patients with cystitis: phylogeny, virulence factors, PAIusp subtypes, and mutation patterns
Q45044154Genetic relatedness of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated in south Asia
Q33836661Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification
Q36106220Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans
Q37282428High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.
Q60922671High frequency of mutations in gene associated with quinolones resistance in uropathogenic isolates from the north of Iran
Q36410455High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance
Q96609310Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Q33770211Hypermutable and fluoroquinolone-resistant clinical isolates of Staphylococcus aureus
Q51153258Impact of plasmid-borne oqxAB on the development of fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q52620715Improvement in organic solvent tolerance by double disruptions of proV and marR genes in Escherichia coli.
Q41623941In vitro selection of resistance to pradofloxacin and ciprofloxacin in canine uropathogenic Escherichia coli isolates
Q35758863Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications
Q92538005Increasing Prevalence of ESBL-Producing Multidrug Resistance Escherichia coli From Diseased Pets in Beijing, China From 2012 to 2017
Q43181792Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria
Q34073057Induction of resistant mutants of Salmonella enterica serotype Typhi under ciprofloxacin selective pressure
Q42861027Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin
Q21146100Inhibition of mutation and combating the evolution of antibiotic resistance
Q28551361Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive Treatment
Q41220729Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli
Q42201141Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q28475870Interplay in the selection of fluoroquinolone resistance and bacterial fitness
Q37052814Levofloxacin in the treatment of complicated urinary tract infections and acute pyelonephritis
Q57922545Low-Level Antimicrobials in the Medicinal Leech Select for Resistant Pathogens That Spread to Patients
Q28542920Mathematical modeling of bacterial kinetics to predict the impact of antibiotic colonic exposure and treatment duration on the amount of resistant enterobacteria excreted
Q54330643Mechanisms accounting for fluoroquinolone multidrug resistance Escherichia coli isolated from companion animals.
Q36155441Mechanisms of resistance to quinolones
Q50097364Methods to Determine Mutational Trajectories After Experimental Evolution of Antibiotic Resistance
Q40412595Molecular analysis of high-level ciprofloxacin resistance in Salmonella enterica serovar Typhi and S. Paratyphi A: need to expand the QRDR region?
Q39020968Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli
Q46610974Mutations in the gyrA and parC genes in ciprofloxacin-resistant clinical isolates of Acinetobacter baumannii in Korea
Q34931378N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors
Q92895032Next-generation strategy for treating drug resistant bacteria: Antibiotic hybrids
Q33836603Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates
Q37735314Occurrence of urinary tract infection in adolescent and adult women of shanty town in Dhaka City, Bangladesh
Q36903693Optimizing drug exposure to minimize selection of antibiotic resistance
Q40666822Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli
Q64092139Phenotypic and genotypic characteristics of with non-susceptibility to quinolones isolated from environmental samples on pig farms
Q37364771Plasmid-Mediated Quinolone-Resistance (qnr) Genes in Clinical Isolates of Escherichia coli Collected from Several Hospitals of Qazvin and Zanjan Provinces, Iran.
Q40368674Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions.
Q37007127Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates
Q89591629Population bottlenecks strongly influence the evolutionary trajectory to fluoroquinolone resistance in Escherichia coli
Q30397339Population structure of Japanese extraintestinal pathogenic Escherichia coli and its relationship with antimicrobial resistance
Q47123962Prevalence and characteristics of ST131 clone among unselected clinical Escherichia coli in a Chinese university hospital
Q38270541Prevalence of hypermutators among clinical Acinetobacter baumannii isolates
Q37798457Quinolone and cephalosporin resistance in enteric fever
Q36057372Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.
Q36189712Quinolone-resistant Shigella flexneri isolated in a patient who travelled to India
Q43098014Quorum-sensing regulator sdiA and marA overexpression is involved in in vitro-selected multidrug resistance of Escherichia coli
Q83230169Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion
Q41913112Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosa
Q41975822Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates
Q40597303Reversing bacterial resistance to antibiotics by phage-mediated delivery of dominant sensitive genes
Q54377726Risk factors and mechanisms of fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections.
Q35059167Salmonella and Escherichia coli contamination of poultry meat from a processing plant and retail markets in Ibadan, Oyo State, Nigeria
Q38220609Selection and evolution of resistance to antimicrobial drugs
Q40968026Single-nucleotide polymorphism mutation spectra and resistance to quinolones in Salmonella enterica serovar Enteritidis with a mutator phenotype
Q90296284Soft sweep development of resistance in Escherichia coli under fluoroquinolone stress
Q42880673Study of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants
Q37049823Temporal changes in resistance mechanisms in colonizing Escherichia coli isolates with reduced susceptibility to fluoroquinolones
Q35606622The Goldilocks principle and antibiotic resistance in bacteria
Q26786956The Three Bacterial Lines of Defense against Antimicrobial Agents
Q54331161The first report of the qnrB19, qnrS1 and aac(6´)-Ib-cr genes in urinary isolates of ciprofloxacin-resistant Escherichia coli in Brazil.
Q98157764The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China
Q33964949The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients
Q39024870The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates
Q36458378The treatment of urinary tract infections and use of ciprofloxacin extended release
Q37612974Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648.
Q37023257Urinary Tract Physiological Conditions Promote Ciprofloxacin Resistance in Low-Level-Quinolone-Resistant Escherichia coli.
Q43643443Vertical transmission of a fluoroquinolone-resistant Escherichia coli within an integrated broiler operation.
Q38665569Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli
Q47709543Whole-genome sequencing and genetic analysis reveals novel stress responses against individual constituents of essential oils in Escherichia coli.

Search more.