Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens

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Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI115301
P932PMC publication ID296041
P698PubMed publication ID2056129
P5875ResearchGate publication ID21100158

P2093author name stringM A Horwitz
T F Byrd
P2860cites workInterferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of ironQ34571751
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Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytesQ37027949
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The Effect of pH upon Human Transferrin: Selective Labelling of the Two Iron-binding SitesQ39080353
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Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparumQ39663518
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Chloroquine treatment in rheumatoid arthritis. Correlation of clinical response to plasma protein changes and chloroquine levelsQ40972345
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Chloroquine: mode of actionQ41942231
Uptake of ferritin and iron bound to ferritin by rat hepatocytes: modulation by apotransferrin, iron chelators and chloroquineQ41946261
The kinetics and mechanism of iron(3) exchange between chelates and transferrin. IV. The reaction of transferrin with iron(3) nitrilotriacetate.Q44399118
A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptorQ47907949
A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum 'in vitro': the unimportance of serum iron.Q47918674
Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine.Q47986167
Transferrin protein and iron uptake by cultured rat fibroblastsQ66980401
Transferrin receptors and transferrin iron uptake by cultured human blood monocytesQ69212363
Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilizationQ70104476
Plasmodium falciparum takes up iron from transferrinQ70380208
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cellsQ72883390
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectchloroquineQ422438
Legionella pneumophilaQ147885
P304page(s)351-357
P577publication date1991-07-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleChloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens
P478volume88

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