Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron

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Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI114038
P932PMC publication ID303847
P698PubMed publication ID2496141

P2093author name stringHorwitz MA
Byrd TF
P2860cites workResponse of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomesQ31154479
Primary isolation media for Legionnaires disease bacteriumQ34564477
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisoneQ34613387
Interaction of primate alveolar macrophages and Legionella pneumophilaQ35208609
Legionella pneumophila inhibits acidification of its phagosome in human monocytesQ36212159
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruziQ36341492
Activated human monocytes inhibit the intracellular multiplication of legionnaires' disease bacteriaQ36345801
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytesQ36348251
Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytesQ36348349
Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophagesQ36348487
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytesQ36349063
Ligated complement receptors do not activate the arachidonic acid cascade in resident peritoneal macrophagesQ36349911
Deferoxamine inhibition of malaria is independent of host iron statusQ36355145
Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptorsQ36357516
The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasitesQ36512530
Interaction of L cells and Chlamydia psittaci: entry of the parasite and host responses to its developmentQ36775853
Cell-mediated Immunity in Legionnaires' DiseaseQ36989852
Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cellsQ37026650
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytesQ37027949
pH and the recycling of transferrin during receptor-mediated endocytosisQ37609089
Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathwayQ39341143
Low molecular weight intracellular iron transport compoundsQ39634380
Fusion of Host Cell Secondary Lysosomes with the Parasitophorous Vacuoles ofLeishmania mexicana-inlected MacrophagesQ39963493
Absence of siderophore activity in Legionella species grown in iron-deficient mediaQ39975593
The pathology of the Legionella pneumonias. A review of 74 cases and the literatureQ40100653
Active Oxygen Species and the Functions of Phagocytic LeukocytesQ40121533
Role of iron in intracellular growth of Trypanosoma cruzi.Q40177263
Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophilaQ41381283
Complete inhibition of transferrin recycling by monensin in K562 cells.Q41918071
Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytesQ42012431
Activation of human macrophages. Comparison of other cytokines with interferon-gammaQ42232581
Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cellsQ42940757
Chelate mediated transfer of iron from transferrin to desferrioxamineQ44413994
Interferon-gamma suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophanQ45350192
Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine.Q47986167
Studies of in vitro infection by Trypanosoma cruzi. I. Ultrastructural studies on the invasion of macrophages and L-cellsQ66891796
Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitroQ67775834
Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell culturesQ69005518
Expression of the transferrin receptor gene during the process of mononuclear phagocyte maturationQ70123156
Expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activationQ70202254
In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant gamma interferonQ70322861
IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophilaQ70389642
Mobilisation of Iron from Peritoneal Rat Macrophages by DesferrioxamineQ71017080
The Site of Action of DesferrioxamineQ71775113
Expression of transferrin receptors and intracellular ferritin during terminal differentiation of human monocytesQ72392687
Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gammaQ72405356
Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systemsQ72951635
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectironQ677
Legionella pneumophilaQ147885
P304page(s)1457-1465
P577publication date1989-05-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleInterferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
P478volume83

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