Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing

scientific article

Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1261/RNA.5170704
P932PMC publication ID1370527
P698PubMed publication ID14730014
P5875ResearchGate publication ID277437500

P2093author name stringLarry Simpson
Ruslan Aphasizhev
Guanghan Gao
Xuedong Kang
P2860cites workTbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosomeQ44487520
Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei.Q44499264
Native gel analysis of ribonucleoprotein complexes from a Leishmania tarentolae mitochondrial extractQ46709089
Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editingQ46840499
An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma bruceiQ46859677
Trypanosoma brucei TBRGG1, a mitochondrial oligo(U)-binding protein that co-localizes with an in vitro RNA editing activityQ47682066
RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA.Q54649086
A putative RNA helicase of the DEAD box family from Trypanosoma bruceiQ61566386
Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editingQ71000760
RNA ligase and its involvement in guide RNA/mRNA chimera formation. Evidence for a cleavage-ligation mechanism of Trypanosoma brucei mRNA editingQ71686585
Kinetoplastid RNA editing ligases: complex association, characterization, and substrate requirementsQ73208318
RNA editing-associated protein 1 is an RNA binding protein with specificity for preedited mRNAQ73835319
Large-scale proteomic analysis of the human spliceosomeQ24671785
Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joiningQ27628850
RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferasesQ28273119
Roles for ligases in the RNA editing complex of Trypanosoma brucei: band IV is needed for U-deletion and RNA repair.Q28348370
Identification of candidate mitochondrial RNA editing ligases from Trypanosoma bruceiQ28358265
Annealing of RNA editing substrates facilitated by guide RNA-binding protein gBP21Q28360230
Association of guide RNA binding protein gBP21 with active RNA editing complexes in Trypanosoma bruceiQ33780973
Kinetoplastid RNA-editing-associated protein 1 (REAP-1): a novel editing complex protein with repetitive domains.Q33889874
Cloning and characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata: gBP27, a novel protein, and gBP29, the orthologue of Trypanosoma brucei gBP21Q33940631
Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complexQ33966791
Four related proteins of the Trypanosoma brucei RNA editing complex.Q34012441
Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domainsQ34189415
Assembly and function of the RNA editing complex in Trypanosoma brucei requires band III proteinQ34278417
Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondriaQ34582995
Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex businessQ35068202
Composition of the editing complex of Trypanosoma bruceiQ35212972
A tale of two TUTasesQ35977107
Trypanosome U-deletional RNA editing involves guide RNA-directed endonuclease cleavage, terminal U exonuclease, and RNA ligase activitiesQ37376878
RNA-binding properties of the mitochondrial Y-box protein RBP16.Q38315652
Trypanosome RNA editing: simple guide RNA features enhance U deletion 100-fold.Q39457744
The two RNA ligases of the Trypanosoma brucei RNA editing complex: cloning the essential band IV gene and identifying the band V geneQ39526694
Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editingQ39618738
TbMP81 is required for RNA editing in Trypanosoma bruceiQ39647029
Distinct functions of two RNA ligases in active Trypanosoma brucei RNA editing complexes.Q39674967
A three-dimensional working model for a guide RNA from Trypanosoma bruceiQ39720238
Trypanosoma brucei U insertion and U deletion activities co-purify with an enzymatic editing complex but are differentially optimized.Q39724699
Complexes from Trypanosoma brucei that exhibit deletion editing and other editing-associated propertiesQ40018473
Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAsQ40023139
Trypanosoma bruceimitochondria contain RNA helicase activityQ40522186
Identification of novel components of Trypanosoma brucei editosomesQ41827505
A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing componentsQ41944052
RBP16 is a multifunctional gene regulatory protein involved in editing and stabilization of specific mitochondrial mRNAs in Trypanosoma bruceiQ42254260
Trypanosoma brucei RBP16 is a mitochondrial Y-box family protein with guide RNA binding activityQ42599523
Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondriaQ42623988
Trypanosoma brucei gBP21. An arginine-rich mitochondrial protein that binds to guide RNA with high affinityQ42648911
Isolation and characterization of a U-specific 3'-5'-exonuclease from mitochondria of Leishmania tarentolaeQ43560416
Is the Trypanosoma brucei REL1 RNA ligase specific for U-deletion RNA editing, and is the REL2 RNA ligase specific for U-insertion editing?Q44441848
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecteukaryoteQ19088
regulation of gene expressionQ411391
mitochondrial proteinQ67455737
P304page(s)159-170
P577publication date2004-02-01
P1433published inRNAQ7277164
P1476titleMitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing
P478volume10

Reverse relations

cites work (P2860)
Q367178493' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria
Q35825849A novel gene expression pathway regulated by nuclear phosphoinositides
Q33648319A protein-protein interaction map of trypanosome ~20S editosomes.
Q42851304An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei.
Q34786406Channelrhodopsin-1 initiates phototaxis and photophobic responses in chlamydomonas by immediate light-induced depolarization
Q35708189Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae
Q34365769Complete cycles of bloodstream trypanosome RNA editing in vitro
Q34034508Complete set of mitochondrial pan-edited mRNAs in Leishmania mexicana amazonensis LV78.
Q42040628Compositionally and functionally distinct editosomes in Trypanosoma brucei
Q27675299Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody
Q41149338Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei.
Q37168963Differential functions of two editosome exoUases in Trypanosoma brucei.
Q37355962Distinct and overlapping functions of MRP1/2 and RBP16 in mitochondrial RNA metabolism.
Q36572673Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex
Q52769819Epidemiological survey of Lutzomyia longipalpis infected by Leishmania infantum in an endemic area of Brazil.
Q37388514Evidence for U-tail stabilization of gRNA/mRNA interactions in kinetoplastid RNA editing
Q27671578Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds
Q39357637Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes.
Q36246623Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei
Q33935232Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase
Q35740567Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species
Q37104541Guide RNA-binding complex from mitochondria of trypanosomatids
Q42920811Guide to the nomenclature of kinetoplastid RNA editing: a proposal
Q33582790Impact of human pathogenic micro-insertions and micro-deletions on post-transcriptional regulation
Q41876511Interactions of mRNAs and gRNAs involved in trypanosome mitochondrial RNA editing: structure probing of a gRNA bound to its cognate mRNA.
Q64462850Isolation and Compositional Analysis of Trypanosomatid Editosomes
Q42250864KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei
Q36400713KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei
Q39887972Kinetoplastid RNA editing involves a 3' nucleotidyl phosphatase activity
Q44620432Kinetoplastid RNA editing ligases 1 and 2 exhibit different electrostatic properties
Q43155266Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase.
Q28484484Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis
Q92172507Leishmania tarentolae: Taxonomic classification and its application as a promising biotechnological expression host
Q35863259Leishmania tarentolae: an alternative approach to the production of monoclonal antibodies to treat emerging viral infections
Q42718517MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process
Q50059602MRB7260 is essential for productive protein-RNA interactions within the RNA Editing Substrate Binding Complex during trypanosome RNA editing
Q24814541Minimal pre-mRNA substrates with natural and converted sites for full-round U insertion and U deletion RNA editing in trypanosomes.
Q33770664Mitochondrial DNA ligases of Trypanosoma brucei
Q39904348Molecular identification of Lutzomyia migonei (Diptera: Psychodidae) as a potential vector for Leishmania infantum (Kinetoplastida: Trypanosomatidae).
Q42326149Multifunctional G-rich and RRM-containing domains of TbRGG2 perform separate yet essential functions in trypanosome RNA editing
Q35557665Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing
Q33967980Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition
Q34135184OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity
Q33861101Opposing effects of polyadenylation on the stability of edited and unedited mitochondrial RNAs in Trypanosoma brucei
Q34702943RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction.
Q34702837RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei
Q38335032RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei
Q38342916RNA-editing terminal uridylyl transferase 1: identification of functional domains by mutational analysis
Q80700168RNA-protein interactions in assembled editing complexes in trypanosomes
Q24676059RNA-specific ribonucleotidyl transferases
Q58842888Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
Q35080361Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins
Q33762846Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes.
Q42139042Roles for TbDSS-1 in RNA surveillance and decay of maturation by-products from the 12S rRNA locus
Q46061337Strategies of kinetoplastid cryptogene discovery and analysis
Q33285050Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast
Q36803161Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei
Q27660537Structure of the T. brucei p22 protein, a cytochrome oxidase subunit II (COII) specific RNA editing accessory factor
Q33480457Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria
Q27665314Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
Q38859452Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold
Q53583889Substrate determinants for RNA editing and editing complex interactions at a site for full-round U insertion.
Q33247054Taking U out, with two nucleases?
Q37579589TbDSS-1, an essential Trypanosoma brucei exoribonuclease homolog that has pleiotropic effects on mitochondrial RNA metabolism
Q38289525TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism
Q33747977TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication
Q33506621TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments
Q36575689TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex.
Q34210450TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites
Q37055752Terminal RNA uridylyltransferases of trypanosomes
Q38287368The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei
Q41764960The MRB1 complex functions in kinetoplastid RNA processing.
Q27672489The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate
Q37311342The importance of the 45 S ribosomal small subunit-related complex for mitochondrial translation in Trypanosoma brucei
Q34442347The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomes
Q35270391The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA
Q33527428The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei
Q36909653Trypanosoma brucei ATPase subunit 6 mRNA bound to gA6-14 forms a conserved three-helical structure
Q38569224Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.
Q43077446Trypanosoma brucei RNA editing: coupled cycles of U deletion reveal processive activity of the editing complex.
Q24610301Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing
Q36282126Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates
Q40358260Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein
Q37246104Uridine insertion/deletion RNA editing in trypanosomatid mitochondria: In search of the editosome
Q35158070Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer
Q44577937Uridylate-specific 3' 5'-exoribonucleases involved in uridylate-deletion RNA editing in trypanosomatid mitochondria.
Q36875263Widespread 3'-end uridylation in eukaryotic RNA viruses

Search more.