Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts

scientific article published on November 4, 2010

Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.167528
P8608Fatcat IDrelease_6hjgsw2mmvft7jq374ckvvtwxe
P953full work available at URLhttp://intl.jbc.org/cgi/content/abstract/286/1/511
http://www.jbc.org/content/286/1/511.full.pdf
https://europepmc.org/articles/PMC3013011
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21051537/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21051537/pdf/?tool=EBI
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https://doi.org/10.1074/jbc.m110.167528
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.167528
P932PMC publication ID3013011
P698PubMed publication ID21051537

P2093author name stringNora Rozengurt
Carlos Huang
Enrique Rozengurt
James Sinnett-Smith
Robert Kui
P2860cites workCancer ResearchQ326097
American Journal of PhysiologyQ2160146
The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMPQ42818091
CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cellsQ42822840
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cellsQ42826316
Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cellsQ42831514
Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.Q44198663
Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acidQ44246034
Establishment and characterizaton of intestinal epithelial cell culturesQ44431913
Vasopressin-induced intracellular redistribution of protein kinase D in intestinal epithelial cellsQ44533025
CCK2 (CCK(B)/gastrin) receptor mediates rapid protein kinase D (PKD) activation through a protein kinase C-dependent pathwayQ46279700
Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cellsQ48025785
Colorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patientsQ74006552
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase CmuQ78208164
Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaBQ24300560
Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cellsQ24323078
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathwayQ24337864
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.Q24537123
Spatial and temporal regulation of protein kinase D (PKD)Q24678757
Organizing cell renewal in the intestine: stem cells, signals and combinatorial controlQ28235109
Stem cells, self-renewal, and differentiation in the intestinal epitheliumQ28294807
Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cellsQ28594706
Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defenseQ33178886
Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13.Q34455784
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domainQ35731354
Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cellsQ35929386
Protein kinase D signalingQ36035199
Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteriaQ36200458
Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injuryQ36298383
Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytesQ36368624
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylationQ36741576
Taste receptor signaling in the mammalian gut.Q37007031
Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cellsQ37509292
Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic miceQ38346730
Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonistsQ40169905
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.Q40180678
Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytesQ40322638
EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathwayQ40517007
ANG II stimulates PKC-dependent ERK activation, DNA synthesis, and cell division in intestinal epithelial cellsQ40666082
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.Q40742637
Vasopressin-mediated mitogenic signaling in intestinal epithelial cellsQ40752381
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathwaysQ40763883
Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.Q40798561
PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC.Q40821330
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.Q41078558
Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase.Q41379386
Activation of protein kinase D by signaling through the alpha subunit of the heterotrimeric G protein G(q).Q41714408
Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathwayQ41715660
Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C.Q41728142
Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.Q42136685
Protein kinase D activation by mutations within its pleckstrin homology domain.Q42448861
Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D.Q42460194
Identification of in vivo phosphorylation sites required for protein kinase D activation.Q42462150
Protein kinase D activation by deletion of its cysteine-rich motifsQ42475083
Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13.Q42508695
Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoproteinQ42616154
Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway.Q42795887
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)511-520
P577publication date2010-11-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleProtein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts
Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts
P478volume286

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cites work (P2860)
Q37584504A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development
Q38760403Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
Q89619681Differential Gene Expression Patterns Between Apical and Basal Inner Hair Cells Revealed by RNA-Seq
Q35778013Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.
Q35668781Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium
Q34988846PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors
Q36775710Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552
Q38707749Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Q33626512Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling
Q33606415Protein kinase d as a potential chemotherapeutic target for colorectal cancer
Q36175932Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells
Q30414082Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption

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