Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

scientific article published on 16 March 2009

Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M806554200
P932PMC publication ID2679443
P698PubMed publication ID19289471

P50authorRichard T WaldronQ62566637
P2093author name stringEnrique Rozengurt
James Sinnett-Smith
Rodrigo Jacamo
Osvaldo Rey
Robert Kui
Steven H Young
Yunzu M Wang
P2860cites workSignal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonistsQ22009085
Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi networkQ24290905
Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaBQ24300560
Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cellsQ24323078
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathwayQ24337864
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.Q24537123
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPKQ28259117
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinasesQ28298000
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CQ28327651
Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cellsQ28594706
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.Q33690319
Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1.Q33934437
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmissionQ34226003
Neuropeptides as growth factors for normal and cancerous cellsQ34563386
Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cellsQ35929386
Protein kinase D signalingQ36035199
Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injuryQ36298383
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylationQ36741576
Mitogenic signaling pathways induced by G protein-coupled receptorsQ36929839
Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cellsQ37509292
High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cellsQ37554881
Early signals in the mitogenic responseQ39504519
Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factorQ40243116
Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytesQ40322638
Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasionQ40612668
Tyrosine kinase inhibition: an approach to drug developmentQ40613606
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.Q40742637
Vasopressin-mediated mitogenic signaling in intestinal epithelial cellsQ40752381
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathwaysQ40763883
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykininQ40786481
Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.Q40798561
PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC.Q40821330
Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrateQ41035564
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.Q41078558
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymesQ41173469
Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase.Q41379386
Activation of protein kinase D by signaling through the alpha subunit of the heterotrimeric G protein G(q).Q41714408
Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathwayQ41715660
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agentsQ42062593
Protein kinase D activation by mutations within its pleckstrin homology domain.Q42448861
Identification of in vivo phosphorylation sites required for protein kinase D activation.Q42462150
Protein kinase D activation by deletion of its cysteine-rich motifsQ42475083
Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13.Q42508695
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptorQ42557425
Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway.Q42795887
Bryostatin 1 induces biphasic activation of protein kinase D in intact cellsQ42797815
Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activationQ42803219
Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.Q42808194
Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linkingQ42808474
The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMPQ42818091
CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cellsQ42822840
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cellsQ42826316
G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase CepsilonQ42828192
Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cellsQ42831514
Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motilityQ42832109
Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.Q44198663
Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acidQ44246034
CCK2 (CCK(B)/gastrin) receptor mediates rapid protein kinase D (PKD) activation through a protein kinase C-dependent pathwayQ46279700
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase CmuQ78208164
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)13434-13445
P577publication date2009-03-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleProtein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation
P478volume284

Reverse relations

cites work (P2860)
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Q33615492CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway
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Q39645306Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors
Q33820455Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer
Q30428751Design, Synthesis, and Biological Evaluation of PKD Inhibitors
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Q41489966Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues.
Q37417683Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling
Q37601331Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System
Q37050910Extracellular nucleotides inhibit oxalate transport by human intestinal Caco-2-BBe cells through PKC-δ activation
Q36494649Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells.
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Q36084010Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer
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Q46471150KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops
Q34438891Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction
Q30524184PKCβII modulation of myocyte contractile performance
Q34988846PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors
Q39646301PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression
Q36775710Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552
Q34452638Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts
Q28505832Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes
Q34675735Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes
Q35097285Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation
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Q35239280Protein kinase D signaling: multiple biological functions in health and disease
Q39540024Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia
Q38707749Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Q33626512Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling
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Q89599165Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases
Q35776742Regulation of protein kinase D1 activity
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Q28543910SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest
Q30414082Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption
Q34999635Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D
Q34784001TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts
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Q92241890[Role of protein kinase D1 in regulating the growth, apoptosis and drug sensitivity of oral squamous carcinoma cells]
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