| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0070-2153(06)76004-5 |
| P698 | PubMed publication ID | 17118265 |
| P50 | author | Sergio Roman-Roman | Q41606759 |
| P2093 | author name string | Roland Baron | |
| Sergio Roman-Roman | |||
| Georges Rawadi | |||
| P2860 | cites work | Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity | Q22004159 |
| A new secreted protein that binds to Wnt proteins and inhibits their activities | Q22009380 | ||
| Functional and structural diversity of the human Dickkopf gene family | Q22010830 | ||
| LDL-receptor-related proteins in Wnt signal transduction | Q24290392 | ||
| Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) | Q24290838 | ||
| Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled | Q24292013 | ||
| The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation | Q24292169 | ||
| A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling | Q24301647 | ||
| Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia | Q24309601 | ||
| Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | Q24311356 | ||
| A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor | Q24313393 | ||
| Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density | Q24531981 | ||
| Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein | Q24536172 | ||
| Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion | Q24541297 | ||
| A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait | Q24561917 | ||
| GSK-3: tricks of the trade for a multi-tasking kinase | Q24624069 | ||
| A molecular mechanism for the effect of lithium on development | Q24629067 | ||
| Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist | Q24646652 | ||
| Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) | Q24676891 | ||
| Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease | Q24679575 | ||
| Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models | Q24796232 | ||
| LDL-receptor-related protein 6 is a receptor for Dickkopf proteins | Q28116567 | ||
| Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway | Q28118992 | ||
| Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development | Q28119185 | ||
| High bone mass in mice expressing a mutant LRP5 gene | Q28180741 | ||
| Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling | Q28202812 | ||
| Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling | Q28202999 | ||
| LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development | Q28206790 | ||
| A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population | Q28214572 | ||
| High bone density due to a mutation in LDL-receptor-related protein 5 | Q28217891 | ||
| Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation | Q28240596 | ||
| Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis | Q28248087 | ||
| LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way | Q28256465 | ||
| Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation | Q28269067 | ||
| Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family | Q28279615 | ||
| Cloning of a novel member of the low-density lipoprotein receptor family | Q28280437 | ||
| Bone morphogenetic proteins | Q28300236 | ||
| Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein | Q28306004 | ||
| Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation | Q28505419 | ||
| Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes | Q28505614 | ||
| Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6 | Q28506732 | ||
| The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice | Q28508070 | ||
| Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton | Q28508641 | ||
| Regulation of osteoblastogenesis and bone mass by Wnt10b | Q28509048 | ||
| Sequential roles of Hedgehog and Wnt signaling in osteoblast development | Q28509123 | ||
| An LDL-receptor-related protein mediates Wnt signalling in mice | Q28588625 | ||
| Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor | Q28590950 | ||
| Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis | Q28591573 | ||
| Essential role of beta-catenin in postnatal bone acquisition | Q28594492 | ||
| A mechanism for Wnt coreceptor activation | Q28641243 | ||
| Osteoclast differentiation and activation | Q29547556 | ||
| Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction | Q29616164 | ||
| arrow encodes an LDL-receptor-related protein essential for Wingless signalling | Q29618701 | ||
| A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling | Q29619294 | ||
| A new member of the frizzled family from Drosophila functions as a Wingless receptor | Q29620189 | ||
| Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator | Q33182261 | ||
| Ci: a complex transducer of the hedgehog signal | Q33756091 | ||
| Wnt signaling: an embarrassment of receptors. | Q34117437 | ||
| Tcf/Lef transcription factors during T-cell development: unique and overlapping functions | Q34120961 | ||
| Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism | Q34284209 | ||
| New aspects of Wnt signaling pathways in higher vertebrates | Q34353150 | ||
| The promise and perils of Wnt signaling through beta-catenin. | Q34647705 | ||
| Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation | Q34732988 | ||
| Frizzled signalling and cell polarisation in Drosophila and vertebrates | Q35202419 | ||
| Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development | Q36010744 | ||
| BMP signaling in skeletal development | Q36032053 | ||
| Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription | Q36370019 | ||
| Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture | Q38363815 | ||
| Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells | Q40373801 | ||
| Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway. | Q40460835 | ||
| Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression | Q40609090 | ||
| BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop | Q40621832 | ||
| The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. | Q40886389 | ||
| Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. | Q41412781 | ||
| Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer | Q41842388 | ||
| Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling | Q41878594 | ||
| Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts | Q42816084 | ||
| Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. | Q44267717 | ||
| A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women | Q46133598 | ||
| Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation | Q46283325 | ||
| The natural history of sclerosteosis | Q46647658 | ||
| A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. | Q48004911 | ||
| Developmental biology: signalling polarity. | Q52119908 | ||
| Wnt signals are targets and mediators of Gli function. | Q52134824 | ||
| Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. | Q52178240 | ||
| Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. | Q52201064 | ||
| Association of functionally different RUNX2 P2 promoter alleles with BMD. | Q53132960 | ||
| TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro | Q81820767 | ||
| Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass | Q83924358 | ||
| P304 | page(s) | 103-127 | |
| P577 | publication date | 2006-01-01 | |
| P1433 | published in | Current Topics in Developmental Biology | Q15745419 |
| P1476 | title | Wnt signaling: a key regulator of bone mass | |
| P478 | volume | 76 |
| Q34016436 | A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition |
| Q24316495 | A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation |
| Q38942872 | AP2 suppresses osteoblast differentiation and mineralization through down-regulation of Frizzled-1. |
| Q50046169 | Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice. |
| Q37407566 | Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and bone |
| Q64112830 | Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery |
| Q37271048 | Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma |
| Q59136499 | Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes |
| Q37318842 | Association of lipid profile with bone mineral density in postmenopausal women in Yazd province |
| Q37222697 | BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. |
| Q39950593 | BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation |
| Q47881918 | Bioinformatics analysis of gene expression profile in callus tissues of osteoporotic phenotype mice induced by osteoblast-specific Krm2 overexpression |
| Q35612746 | CD73-generated adenosine promotes osteoblast differentiation |
| Q51922368 | Canonical Wnt signaling activity during synovial joint development. |
| Q42174982 | Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin |
| Q48762542 | Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study. |
| Q39372266 | Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx. |
| Q39279230 | Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation |
| Q36175093 | Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila. |
| Q34676851 | Conditional deletion of gremlin causes a transient increase in bone formation and bone mass |
| Q24619669 | Control of RANKL gene expression |
| Q37526818 | Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship |
| Q27674857 | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 |
| Q37270725 | Developments in the scientific understanding of osteoporosis |
| Q37122129 | Diagnosis of osteoporosis with vitamin k as a new biochemical marker |
| Q24305287 | Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts |
| Q36086488 | Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast |
| Q38210247 | Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma. |
| Q37136733 | E2F1 effects on osteoblast differentiation and mineralization are mediated through up-regulation of frizzled-1. |
| Q79751142 | Eating bone or adding it: the Wnt pathway decides |
| Q36288966 | Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway |
| Q39883776 | Epithelium-Derived Wnt Ligands Are Essential for Maintenance of Underlying Digit Bone |
| Q35152942 | Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation |
| Q37809213 | Evolution of the parathyroid hormone family and skeletal formation pathways |
| Q33742267 | Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry |
| Q37209139 | Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story? |
| Q30497635 | Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo |
| Q36951167 | Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. |
| Q37112051 | Genetics of pediatric bone strength |
| Q33552875 | Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function |
| Q51543146 | Glycogen Synthase Kinase-3 is involved in glycogen metabolism control and embryogenesis of Rhodnius prolixus. |
| Q34776085 | HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts |
| Q39342144 | Higher serum sclerostin levels and insufficiency of vitamin D are strongly associated with vertebral fractures in hemodialysis patients: a case control study. |
| Q93370750 | Impact of Route of Estrogen Administration on Bone Turnover Markers in Oligoamenorrheic Athletes and Its Mediators |
| Q51621260 | Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head. |
| Q37457253 | In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin |
| Q24601727 | Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading |
| Q87933642 | Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women |
| Q33782750 | Inflammation and the osteogenic regulation of vascular calcification: a review and perspective |
| Q28591491 | Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2 |
| Q33659925 | Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies |
| Q89508418 | Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a |
| Q92604699 | Isopsoralen ameliorates H2O2-induced damage in osteoblasts via activating the Wnt/β-catenin pathway |
| Q41873508 | LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo. |
| Q37378529 | Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway |
| Q35763278 | Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent |
| Q35435068 | Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. |
| Q37056408 | Mechanisms of multiple myeloma bone disease |
| Q33864136 | Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways |
| Q37455934 | Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces |
| Q28586803 | Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings |
| Q33518520 | N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. |
| Q33570529 | Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2. |
| Q28510813 | Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity |
| Q33521540 | No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families |
| Q33436209 | Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate |
| Q26853017 | Nuclear receptors in bone physiology and diseases |
| Q33926385 | Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse |
| Q37981072 | Osteocyte regulation of bone mineral: a little give and take. |
| Q24655113 | Osteoimmunology: interactions of the bone and immune system |
| Q38960189 | Osteoimmunology: memorandum for rheumatologists. |
| Q28567926 | Parathyroid hormone signaling through low-density lipoprotein-related protein 6 |
| Q38015689 | Perspectives on cancer stem cells in osteosarcoma |
| Q47120342 | Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells. |
| Q47664076 | Plasticizer di(2-ethylhexyl)phthalate interferes with osteoblastogenesis and adipogenesis in a mouse model. |
| Q41726644 | Role of Wnt signaling in bone remodeling and repair |
| Q34764595 | Role of calcitonin gene-related peptide in functional adaptation of the skeleton. |
| Q42371007 | SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes |
| Q39659778 | Sclerostin is a direct target of osteoblast-specific transcription factor osterix |
| Q35983181 | Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism |
| Q31032805 | Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway |
| Q37687505 | Serum response factor regulates bone formation via IGF-1 and Runx2 signals |
| Q87182883 | Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients? |
| Q36845086 | Serum β -Catenin Levels Associated with the Ratio of RANKL/OPG in Patients with Postmenopausal Osteoporosis |
| Q42562772 | Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells |
| Q33693295 | Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation |
| Q33985899 | Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation |
| Q36756829 | Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis |
| Q36954369 | The enigmas of bone without osteocytes |
| Q37285682 | The first propeller domain of LRP6 regulates sensitivity to DKK1. |
| Q39670079 | The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts |
| Q51790755 | The p38α MAPK positively regulates osteoblast function and postnatal bone acquisition. |
| Q37919693 | The regulation of valvular and vascular sclerosis by osteogenic morphogens |
| Q85182025 | The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density |
| Q97088370 | Titanium particles damage osteocytes and inhibit osteoblast differentiation |
| Q37434321 | Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling |
| Q38552664 | Twist as a new prognostic marker in hematological malignancies. |
| Q58108789 | Why SNP rs227584 is associated with human BMD and fracture risk? A molecular and cellular study in bone cells |
| Q37836495 | Why TNF-α inhibition is not sufficient to avoid juxta-articular erosions in chronic arthritis? |
| Q37542905 | Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis |
| Q35156225 | Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. |
| Q33736936 | Wnt signaling in angiogenesis |
| Q38609596 | Wnt/β-catenin signaling in bone marrow niche. |
| Q33833409 | Wnts' fashion statement: from body stature to dysplasia |
| Q64062195 | Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis |
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