Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy.

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Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.3374D
P356DOI10.1073/PNAS.1501985112
P932PMC publication ID4371905
P698PubMed publication ID25713345
P5875ResearchGate publication ID272840327

P50authorG. Marius CloreQ19864601
P2093author name stringLalit Deshmukh
Rodolfo Ghirlando
P2860cites workThe prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particlesQ21245046
Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesisQ24498694
Structural determinants and mechanism of HIV-1 genome packagingQ24632055
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solutionQ24649924
Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyproteinQ27639039
Structure of the HIV-1 Full-Length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-Molecule BindingQ27666307
Structure and Dynamics of Full-Length HIV-1 Capsid Protein in SolutionQ27680056
Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopyQ27681296
Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometryQ27684164
Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivityQ27685488
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolutionQ27696126
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assemblyQ27732646
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
Weak alignment NMR: a hawk-eyed view of biomolecular structureQ28270452
HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acidQ30397032
Assembly and architecture of HIV.Q30455050
Analysis of the initiating events in HIV-1 particle assembly and genome packagingQ30992792
Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domainQ33667586
Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopyQ33724969
Sequence-specific binding of human immunodeficiency virus type 1 nucleocapsid protein to short oligonucleotidesQ33782302
Structural basis of the association of HIV-1 matrix protein with DNA.Q33784526
Facile measurement of 1H–15N residual dipolar couplings in larger perdeuterated proteinsQ34180079
Prediction of human immunodeficiency virus protease cleavage sites in proteinsQ34395418
Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein functionQ34775654
Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.Q34984031
Conformation of the HIV-1 Gag protein in solution.Q35785819
Magic angle spinning NMR reveals sequence-dependent structural plasticity, dynamics, and the spacer peptide 1 conformation in HIV-1 capsid protein assembliesQ37592317
HIV-1 assembly, budding, and maturationQ38023864
HIV Gag polyprotein: processing and early viral particle assemblyQ38069726
The roles of lipids and nucleic acids in HIV-1 assemblyQ38219405
Higher-order structure of the Rous sarcoma virus SP assembly domainQ39549065
Characterization of the invariable residue 51 mutations of human immunodeficiency virus type 1 capsid protein on in vitro CA assembly and infectivityQ39756191
Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 gag polyproteinQ40059062
Assembly properties of the human immunodeficiency virus type 1 CA proteinQ40676680
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Determining the structures of large proteins and protein complexes by NMR.Q41704452
Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelopeQ42825525
Flexibility in the P2 domain of the HIV-1 Gag polyproteinQ43094794
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
Structure of the amino-terminal core domain of the HIV-1 capsid proteinQ71142552
Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replicationQ73514585
Rapid identification of medium- to large-scale interdomain motion in modular proteins using dipolar couplingsQ74431681
Evaluation of uncertainty in alignment tensors obtained from dipolar couplingsQ74555398
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278)Q80280623
P4510describes a project that usesNMR spectroscopyQ10359898
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectHIV type 1Q18907320
P304page(s)3374-3379
P577publication date2015-02-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleConformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy
P478volume112

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cites work (P2860)
Q475538881H, 13C and 15N backbone and partial side-chain resonance assignments of the C-terminal domain of HIV-1 Pr55Gag encompassed in NCp15.
Q41730903A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro
Q52448866Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR.
Q37237447Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme
Q36961546Dynamic Nuclear Polarization Enhanced MAS NMR Spectroscopy for Structural Analysis of HIV-1 Protein Assemblies
Q58597952HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites
Q30276000Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles
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Q30387493Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments
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Q28074527Structural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic Instability
Q27321387The Structure of Immature Virus-Like Rous Sarcoma Virus Gag Particles Reveals a Structural Role for the p10 Domain in Assembly.
Q27303006The matrix domain contributes to the nucleic acid chaperone activity of HIV-2 Gag.
Q37398034Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations