B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection

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B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1101006
P932PMC publication ID3173872
P698PubMed publication ID21841129
P5875ResearchGate publication ID51571007

P2093author name stringGeorge Kassiotis
Mickaël J-Y Ploquin
Urszula Eksmond
P2860cites workGerminal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)Q24599046
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Follicular helper T cells: lineage and locationQ24647274
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationQ24675931
PD-L2 is a second ligand for PD-1 and inhibits T cell activationQ28202471
Immunity to retroviral infection: the Friend virus modelQ28243606
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
STAT3 regulates cytokine-mediated generation of inflammatory helper T cellsQ28286840
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responsesQ33247469
The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune responseQ33296970
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperationQ33652505
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.Q33695371
Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected miceQ33783475
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsQ33866996
Role of antigen persistence and dose for CD4+T-cell exhaustion and recoveryQ34377134
Plasma cells negatively regulate the follicular helper T cell programQ34683989
Germinal center B cell and T follicular helper cell development initiates in the interfollicular zoneQ35758747
A role for B cells in the development of T cell helper function in a malaria infection in miceQ35887028
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.Q36206343
Successful T cell priming in B cell-deficient miceQ36365741
Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivoQ36370731
T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivoQ36404561
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virusQ37019625
T follicular helper (TFH) cells in normal and dysregulated immune responsesQ37049341
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathologyQ37074537
SAP-controlled T-B cell interactions underlie germinal centre formationQ37119530
B lymphocyte activation by coinfection prevents immune control of friend virus infectionQ37128255
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor bindingQ37266009
Cytokine-secreting follicular T cells shape the antibody repertoireQ37270592
SLAM receptors and SAP influence lymphocyte interactions, development and functionQ37349689
Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus.Q37349889
Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infectionQ37410816
Effector and regulatory B cells: modulators of CD4+ T cell immunityQ37708012
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
A kinetic basis for T cell receptor repertoire selection during an immune responseQ41649927
Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell responseQ41773067
T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activationQ41895228
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6Q42136332
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cellsQ42806482
CD4+ T cell activation and tolerance induction in B cell knockout miceQ42943396
Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells.Q43508744
SAP controls T cell responses to virus and terminal differentiation of TH2 cells.Q43692363
Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.Q43967678
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain geneQ46098688
The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in toleranceQ46211894
Ligand recognition by alpha beta T cell receptorsQ46222293
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.Q50736370
B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection.Q51982838
B cells inhibit induction of T cell-dependent tumor immunity.Q53682449
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.Q55054413
Impaired T cell immunity in B cell-deficient mice following viral central nervous system infectionQ74244258
B lymphocytes as antigen-presenting cells for CD4+ T cell priming in vivoQ77404703
Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding propertiesQ80991133
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3321-3330
P577publication date2011-08-12
P1433published inJournal of ImmunologyQ3521441
P1476titleB cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection
P478volume187

Reverse relations

cites work (P2860)
Q34383687Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation
Q41957699B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection
Q39852423Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
Q59360810CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection
Q36837631CD4 T cell responses in latent and chronic viral infections
Q92497684CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells
Q33993393Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.
Q55382966Correlates of Follicular Helper Bias in the CD4 T Cell Response to a Retroviral Antigen.
Q92095234Default polyfunctional T helper 1 response to ample signal 1 alone
Q57490848Determination of T Follicular Helper Cell Fate by Dendritic Cells
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Q27003380Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model
Q26995251Effective T helper cell responses against retroviruses: are all clonotypes equal?
Q92005460Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
Q55196315Inverse comorbidity: the power of paradox in the advancement of science.
Q26796086Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response
Q34270466Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection
Q40469638Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.
Q36506961Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.
Q100316573Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions
Q38264816T follicular helper cell differentiation, function, and roles in disease
Q38185124T helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organ transplantation
Q54976588Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4+ T lymphocyte response.
Q34450488The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization

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