A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

scientific article

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2958.2011.07568.X
P932PMC publication ID3178796
P698PubMed publication ID21306441
P5875ResearchGate publication ID49822268

P50authorJaclyn S PearsonQ58204671
Gad FrankelQ63865535
Elizabeth L. HartlandQ47502191
P2093author name stringPatrice Riedmaier
Olivier Marchès
P2860cites workNleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligasesQ21131552
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory responseQ22001534
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosisQ24304013
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1Q24316986
PROSITE, a protein domain database for functional characterization and annotationQ24644916
A unique signature identifies a family of zinc-dependent metallopeptidases.Q54672503
Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleEQ57676051
Enteropathogenic and enterohaemorrhagic Escherichia coli : more subversive elementsQ59307481
Crystal structure of enteropathogenic Escherichia coli intimin-receptor complexQ27625285
Metalloprotease type III effectors that specifically cleave JNK and NF-κBQ28116010
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
NF-kappaB regulation in the immune systemQ28205043
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IpafQ28506503
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signallingQ29568915
Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulationQ33274199
Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coliQ33406647
The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestalsQ33518483
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.Q33582255
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasomeQ33733606
NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infectionQ33733678
Genomic characterization of the Yersinia genusQ33762297
NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelAQ33780981
Virulence is positively selected by transmission success between mammalian hostsQ34003664
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymesQ34048081
The draft genome sequence of Arsenophonus nasoniae, son-killer bacterium of Nasonia vitripennis, reveals genes associated with virulence and symbiosisQ34099527
Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.Q34462401
Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentiumQ34492843
Emergence, distribution, and molecular and phenotypic characteristics of Salmonella enterica serotype 4,5,12:i:-.Q35267925
Cleavage of p65/RelA of the NF-kappaB pathway by ChlamydiaQ35669819
Bacterial peptidasesQ35924173
Type III secretion systems and diseaseQ36969851
Inhibition of NF-κB Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia coli Effector Protein NleEQ39656775
The phosphothreonine lyase activity of a bacterial type III effector familyQ40170436
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responsesQ40198172
Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivo.Q40293264
AIP56, a novel plasmid-encoded virulence factor of Photobacterium damselae subsp. piscicida with apoptogenic activity against sea bass macrophages and neutrophils.Q40355811
Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogensQ40380291
EspM2 is a RhoA guanine nucleotide exchange factorQ40593889
Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cellsQ40958561
The type III secretion effector NleE inhibits NF-kappaB activationQ41893338
Proteasome-independent degradation of canonical NFkappaB complex components by the NleC protein of pathogenic Escherichia coliQ42177912
The ex vivo response of human intestinal mucosa to enteropathogenic Escherichia coli infectionQ42287928
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cellsQ48042079
Type III secretion effectors of the IpaH family are E3 ubiquitin ligasesQ50066742
Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharidesQ50118523
Muramylpeptide shedding modulates cell sensing of Shigella flexneri.Q54430471
A cloned pathogenicity island from enteropathogenic Escherichia coli confers the attaching and effacing phenotype on E. coli K-12.Q54574143
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
NF-κBQ411114
Enteropathogenic Escherichia coliQ13419512
enteropathogenQ63500873
P304page(s)219-230
P577publication date2011-02-22
P1433published inMolecular MicrobiologyQ6895967
P1476titleA type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation
P478volume80

Reverse relations

cites work (P2860)
Q38164827'Drugs from bugs': bacterial effector proteins as promising biological (immune-) therapeutics
Q27315131A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis
Q58572728A Metalloprotease Homolog Venom Protein From a Parasitoid Wasp Suppresses the Toll Pathway in Host Hemocytes
Q37871646Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system
Q47097262Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors
Q35191956Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-κB and p38 mitogen-activated protein kinase activation.
Q26766446Bacterial Toxins as Pathogen Weapons Against Phagocytes
Q38123136Bacterial interference with canonical NFκB signalling.
Q37507829Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells
Q33617012Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve.
Q38318508Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector-mediated subversion of host innate immune pathways
Q59813014Clever Cooperation: Interactions Between EspF and Host Proteins
Q50020373Cooperative Immune Suppression by Escherichia coli and Shigella Effector Proteins
Q38718756Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli
Q40213403Down the rabbit hole: Is necroptosis truly an innate response to infection?
Q41506828Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration
Q34177961Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements
Q42677180Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution
Q38696636Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway.
Q91933031EspFu-Mediated Actin Assembly Enhances Enteropathogenic Escherichia coli Adherence and Activates Host Cell Inflammatory Signaling Pathways
Q34198962EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function
Q47351983Eukaryotic-like Kinase Expression in Enterohemorrhagic Escherichia coli: Potential for Enhancing Host Aggressive Inflammatory Response
Q37987493Flagella and bacterial pathogenicity
Q34263876Functional differences and interactions between the Escherichia coli type III secretion system effectors NleH1 and NleH2.
Q42597736Functional expression, purification, and biochemical properties of subtilase SprP from Pseudomonas aeruginosa
Q91817142Giardia lamblia Decreases NF-κB p65RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages
Q38295538Hijacking of death receptor signaling by bacterial pathogen effectors
Q59125893How a DNA mimic catches and cleaves NF-κB
Q40604251Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ.
Q36466792Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression.
Q38007348Infection strategies of enteric pathogenic Escherichia coli
Q36032316Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD.
Q37214160Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition
Q35636588Manipulation of kinase signaling by bacterial pathogens
Q35163621Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction
Q35108874Microbial strategies for antagonizing Toll-like-receptor signal transduction
Q38994595Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins
Q28083042Modulation of the host innate immune and inflammatory response by translocated bacterial proteins
Q64063136NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
Q36557738NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation
Q42152411Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
Q37319927Pathogenic Lifestyles of E. coli Pathotypes in a Standardized Epithelial Cell Model Influence Inflammatory Signaling Pathways and Cytokines Secretion
Q58610410Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1-Dependent Manner.
Q42860357Proteolytic Cleavage of NF-κB p65: A Novel Mechanism for Subversion of Innate Immune Signaling by Pathogenic E. Coli
Q34375210Recent advances in understanding enteric pathogenic Escherichia coli.
Q37899039Ribosomal protein s3: a multifunctional target of attaching/effacing bacterial pathogens
Q38522801Role of virulence factors on host inflammatory response induced by diarrheagenic Escherichia coli pathotypes
Q37021485Shiga toxin-producing Escherichia coli: factors involved in virulence and cattle colonization
Q27688884Structure and mechanism of a type III secretion protease, NleC
Q57976007Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB
Q41147661Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli
Q28492963Subtilase SprP exerts pleiotropic effects in Pseudomonas aeruginosa
Q37951705Subversion of innate immune responses by bacterial hindrance of NF-κB pathway
Q26773133Subverting Toll-Like Receptor Signaling by Bacterial Pathogens
Q38689964T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-κB p65 Cleavage
Q38643178Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy
Q27684732The Structure and Specificity of the Type III Secretion System Effector NleC Suggest a DNA Mimicry Mechanism of Substrate Recognition
Q36200507The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK.
Q42373973The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner
Q34611109The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65
Q40071930The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).
Q38255302The cell death response to enteropathogenic Escherichia coli infection
Q28478223The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors
Q38071791The impact of Toll-like receptors on bacterial virulence strategies
Q39495822The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300.
Q34596147The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection
Q35947385Tir Triggers Expression of CXCL1 in Enterocytes and Neutrophil Recruitment during Citrobacter rodentium Infection

Search more.