Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes

scientific article

Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.248591
P932PMC publication ID3186365
P698PubMed publication ID21846717

P2093author name stringXuan Ge
Yu Wang
Aimin Xu
Xiaoyan Hui
Cheng Chen
Karen S L Lam
P2860cites workRegulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transductionQ36687724
Mini-review: endocrine actions of fibroblast growth factor 19.Q37052076
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivityQ37328872
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and diseaseQ37781747
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effectsQ38351110
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.Q39581682
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.Q40239037
Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.Q40526751
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entryQ40976467
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytesQ41910885
FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation modelQ42552463
FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivityQ42813458
The role of insulin in activation of two enhancers in the mouse GLUT1 geneQ42832486
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signalingQ42834234
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglycerideQ42950501
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Insulin-stimulated glucose transport minireview seriesQ45083262
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humansQ46770146
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.Q51421300
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5Q24306179
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3cQ24306279
Different roles of N- and C- termini in the functional activity of FGF21Q24312210
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21Q24318639
FGF-21 as a novel metabolic regulatorQ24523933
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinaseQ24564046
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayQ24607012
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant StateQ24625976
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic miceQ24642546
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
BetaKlotho is required for metabolic activity of fibroblast growth factor 21Q24681531
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersQ24683254
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cellsQ33606245
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activationQ33648263
Relevant use of Klotho in FGF19 subfamily signaling system in vivoQ33667883
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.Q33762194
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscleQ33869428
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese ratsQ33930333
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).Q34069794
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.Q34577053
Elk-1 can recruit SRF to form a ternary complex upon the serum response elementQ34593714
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.Q34787051
Fibroblast growth factor 21 corrects obesity in miceQ34805555
Mitogen-activated protein kinases: versatile transducers for cell signalingQ35231791
The serum response elementQ35557503
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
P304page(s)34533-34541
P577publication date2011-08-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleFibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
P478volume286

Reverse relations

cites work (P2860)
Q33906438A link between hepatic glucose production and peripheral energy metabolism via hepatokines
Q92816040Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
Q38027744Adipose tissue, hormones, and treatment of type 1 diabetes.
Q36224779Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth
Q57283864Bile acids and their effects on diabetes
Q37550329Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice
Q34316238Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.
Q27335000Browning of white adipose tissue uncouples glucose uptake from insulin signaling
Q47916949Cardiomyokines from the heart
Q36970160Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21
Q36500607Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation
Q104073661Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects
Q46134650Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Q39115885Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice
Q64105434FGF21 as Modulator of Metabolism in Health and Disease
Q38645276FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
Q47220838FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway
Q64975307FGF21 regulates insulin sensitivity following long-term chronic stress.
Q38794405Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus
Q39325845Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis.
Q26766528Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Q26772751Fibroblast Growth Factor Signaling in Metabolic Regulation
Q39017842Fibroblast growth factor 21 night watch: advances and uncertainties in the field
Q54268091Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway.
Q90212918Functional Implications of DNA Methylation in Adipose Biology
Q46420424Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α.
Q59357132Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
Q37251086High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling
Q28550659Human FGF-21 Is a Substrate of Fibroblast Activation Protein
Q34603941Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice
Q53807997Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway.
Q33648885Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells
Q90240789KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese
Q35274798Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice
Q93080669Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice
Q90223120Metabolic Determinants of Weight Gain in Humans
Q37160100MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity
Q38858879N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway
Q48107382Pharmacokinetics, tissue distribution and excretion of FGF-21 following subcutaneous administration in rats.
Q35256779Placental fibroblast growth factor 21 is not altered in late-onset preeclampsia
Q94560979Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands
Q36760335Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice
Q33847421Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes
Q39042458Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
Q26753369The FGF21-adiponectin axis in controlling energy and vascular homeostasis
Q38750211The emerging role of fibroblast growth factor 21 in diabetic nephropathy
Q98238156The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Q92974039Therapeutic strategies for glucose transporter 1 deficiency syndrome
Q39332431Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat.
Q92524593Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster
Q50578906mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.