IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage

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IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1172/JCI23215
P932PMC publication ID525746
P698PubMed publication ID15545984

P50authorPaulo VieiraQ10346865
Anne O'GarraQ4768689
P2093author name stringAnne E Goldfeld
Pedro L Vieira
P2860cites workA novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
Interleukin-10 and the interleukin-10 receptorQ24290912
Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivityQ24302386
Selective expression of an interleukin-12 receptor component by human T helper 1 cellsQ24670175
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanismsQ24673863
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytesQ24676786
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cellsQ24678065
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cellsQ24802813
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Innate immune recognitionQ27860721
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agentQ28191546
Tolerance, DCs and tryptophan: much ado about IDOQ28203295
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
Immunology of tuberculosisQ29614370
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivityQ71120550
Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivoQ71929873
Clinical and immunopathological aspects of disseminated cutaneous leishmaniasisQ72042604
CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanismQ73020157
The role of IL-10 in promoting disease progression in leishmaniasisQ73365816
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10Q73509865
Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cellsQ73612987
Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10Q77542537
CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in miceQ78701808
Tolerogenic dendritic cellsQ29618755
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Functional diversity of helper T lymphocytesQ29619415
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanismQ33767365
Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytesQ33839633
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharideQ33926019
Signaling and transcription in T helper developmentQ33932729
A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in miceQ34001680
Suppressor T cells: Rebirth, function and homeostasisQ34014450
Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural CambodiaQ34064629
B cells regulate autoimmunity by provision of IL-10.Q34150590
Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapyQ34181985
In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions.Q34184123
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
Regulatory T cells in the control of immune pathology.Q34348983
Role of IL-10 in allergen-specific immunotherapy and normal response to allergensQ34374552
Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infectionQ34443497
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation toleranceQ34448410
Type 1 T regulatory cells.Q34448429
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
Regulatory T cells in the induction and maintenance of peripheral transplantation toleranceQ35069619
IL-10-producing T cells suppress immune responses in anergic tuberculosis patientsQ35159232
Foxp3 and natural regulatory T cells: key to a cell lineage?Q35204514
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expressionQ35474954
Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasisQ35546559
Role of IL-13 in regulation of anti-tumor immunity and tumor growthQ35581077
IDO and tolerance to tumorsQ35628246
Development and function of T helper 1 cellsQ35769454
Regulatory T cells and mechanisms of immune system controlQ35852343
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetesQ35978587
Regulation of immunity to parasites by T cells and T cell-derived cytokinesQ36135203
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.Q36362779
Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous systemQ36363532
Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharideQ36368582
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussiQ36369855
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.Q36370082
Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cellsQ36370232
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.Q36370315
Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.Q36371536
Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitisQ36376571
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cellsQ36376864
Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the diseaseQ36380402
CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease statusQ36399748
Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivoQ36400127
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigensQ36954734
Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector functionQ37094107
Induction and maintenance of anergy in mature T cellsQ37512155
Mycobacterium tuberculosis recall antigens suppress HIV-1 replication in anergic donor cells via CD8+ T cell expansion and increased IL-10 levelsQ39383452
Local role for tumor necrosis factor alpha in the pulmonary inflammatory response to Mycobacterium tuberculosis infectionQ39654413
The curse of Prometheus is laid upon the immune systemQ40308369
Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' miceQ40404888
Lymphocyte responses and cytokinesQ40620203
Cytokine regulation of T-cell function: potential for therapeutic interventionQ40713016
Differential regulation of murine T lymphocyte subsetsQ40898191
Oral tolerance: immune mechanisms and treatment of autoimmune diseasesQ41546336
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosyQ41547320
CD4+ T-cell subsets in autoimmunityQ41716697
Cytokines induce the development of functionally heterogeneous T helper cell subsetsQ41732572
T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) miceQ41911811
Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggeringQ42810147
Blocking the receptor for IL-10 improves antimycobacterial chemotherapy and vaccinationQ43958346
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophagesQ44173170
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clonesQ45010858
Interleukin-10, T regulatory cells and specific allergy treatmentQ47988592
Modifications of CD8+ T cell function during in vivo memory or tolerance inductionQ47992203
Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.Q52051516
CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4Q56903729
Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivoQ56904016
Twenty-first century Foxp3Q56987489
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis PatientsQ61885691
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1372-1378
P577publication date2004-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleIL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage
P478volume114

Reverse relations

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Q38961310TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations.
Q37066512The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression
Q37761493The Family of IL-10-secreting CD4+ T cells
Q41444442The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis.
Q64063170The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
Q26865518The Regulation of CD4(+) T Cell Responses during Protozoan Infections
Q64252919The Role of IL-10 in Malaria: A Double Edged Sword
Q37175810The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease
Q40302787The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells
Q37859621The role of IL-10 in immune regulation during M. tuberculosis infection
Q33719037The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
Q36164906The role of mucosal T lymphocytes in regulating intestinal inflammation
Q35569913The role of regulatory T cell defects in type I diabetes and the potential of these cells for therapy
Q36961031The role of the T-cell costimulatory molecule Tim-1 in the immune response.
Q36535760The role of virus-induced regulatory T cells in immunopathology
Q37872288The suppressive tumor microenvironment: a challenge in cancer immunotherapy
Q36576509The two faces of interleukin 10 in human infectious diseases
Q37356076Therapeutic peptide vaccines for treatment of autoimmune diseases
Q39613283Therapeutic potential of semi-mature dendritic cells for tolerance induction
Q36309544Tipping the balance towards tolerance: the basis for therapeutic immune modulation by gold?
Q84510316Toll-like receptor-4 expression in infants with pertussis infection
Q35935751Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.
Q37684073Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats.
Q27490259Tregs control the development of symptomatic West Nile virus infection in humans and mice
Q36381918Tumor-infiltrating T lymphocytes: friends or foes?
Q37635491Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy
Q36151935Tuning microenvironments: induction of regulatory T cells by dendritic cells
Q64108546Turning the Tide Against Regulatory T Cells
Q37371463Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
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Q37439191mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia
Q95643914miR-374b-5p is increased in deep vein thrombosis and negatively targets IL-10

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