Using Drosophila melanogaster to map human cancer pathways

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Using Drosophila melanogaster to map human cancer pathways is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NRC1671
P698PubMed publication ID16034367
P5875ResearchGate publication ID7711641

P50authorHelena E. RichardsonQ37370291
P2093author name stringAnthony M Brumby
P2860cites workThe Hallmarks of CancerQ221226
Involvement of chemokine receptors in breast cancer metastasisQ24290909
Mammalian Scribble forms a tight complex with the betaPIX exchange factorQ24295230
Segregation of receptor and ligand regulates activation of epithelial growth factor receptorQ24298164
The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machineryQ24557447
Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cellsQ24800512
The Drosophila Sterile-20 Kinase Slik Controls Cell Proliferation and Apoptosis during Imaginal Disc DevelopmentQ24806702
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in DrosophilaQ28131827
Creation of human tumour cells with defined genetic elementsQ28141602
Signal transduction by the JNK group of MAP kinasesQ28142592
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell linesQ28188140
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skinQ28203751
Putting tumours in contextQ28207789
Dpp Signaling Silences bam Transcription Directly to Establish Asymmetric Divisions of Germline Stem CellsQ28210264
Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila.Q52086513
Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.Q52088677
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.Q52096636
Genetic mosaic techniques for studying Drosophila development.Q52100307
Neoplastic Transformation and Aberrant Cell–Cell Interactions in Genetic Mosaics oflethal(2)giant larvae (lgl),a Tumor Suppressor Gene ofDrosophilaQ52205215
Drosophila myc regulates cellular growth during development.Q52573250
Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.Q52602094
Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.Q52652438
Ras pathway signals are required for notch-mediated oncogenesisQ74298005
Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancerQ47070112
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsQ47070295
A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesisQ47070342
Genetic control of cell intercalation during tracheal morphogenesis in DrosophilaQ47070394
Role of DE-Cadherin in Neuroblast Proliferation, Neural Morphogenesis, and Axon Tract Formation inDrosophilaLarval Brain DevelopmentQ47070436
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferationQ47070662
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.Q47070780
The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor PebbleQ47070845
Temporal control of differentiation by the insulin receptor/tor pathway in DrosophilaQ47070849
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.Q47070908
Myosin VI is required for E-cadherin-mediated border cell migrationQ47070917
Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerizationQ47071049
The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanismsQ47071133
Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila.Q47071207
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in DrosophilaQ47071369
Drosophila myc regulates organ size by inducing cell competitionQ47071644
Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye developmentQ47071872
Control of cell proliferation in the Drosophila eye by Notch signaling.Q47072084
dMyc transforms cells into super-competitorsQ47072112
The Drosophila F box protein archipelago regulates dMyc protein levels in vivoQ47072740
Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epitheliaQ47072814
Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brainQ47836373
Coordination of growth and cell division in the Drosophila wingQ47872577
Cancer: dangerous liaisonsQ47929808
Integrin-dependent apposition of Drosophila extraembryonic membranes promotes morphogenesis and prevents anoikis.Q47933095
A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the geneQ48306524
Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genesQ48487355
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditionsQ50319780
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.Q51113909
Growth and differentiation in the Drosophila eye coordinated by hedgehogQ46658867
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell deathQ46725238
Developmental control of blood cell migration by the Drosophila VEGF pathwayQ47070051
Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cueQ28212990
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancerQ28245902
decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovaryQ28278961
NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsQ28511556
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survivalQ28511571
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs largeQ30176301
A directed screen for genes involved in Drosophila blood cell activationQ30833737
Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stemsQ30836305
A survey of human disease gene counterparts in the Drosophila genomeQ30887434
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.Q33205672
Drosophila in cancer research. An expanding role.Q33818861
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural developmentQ33943141
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cellsQ33953411
Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in DrosophilaQ34108115
Enumeration of the simian virus 40 early region elements necessary for human cell transformationQ34117528
A Genetic Screen in Drosophila for Metastatic BehaviorQ34269141
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancerQ34332205
TGF-beta signaling in cancer--a double-edged swordQ34421804
Epithelial cell polarity and cell junctions in DrosophilaQ34432296
The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulationQ34452174
Cell proliferation, survival, and death in the Drosophila eye.Q34458309
Cancer modeling in the modern era: progress and challengesQ34520417
Rho GTPases in transformation and metastasis.Q34554757
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.Q34567130
The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenesQ34718436
Cell movements during gastrulation: snail dependent and independent pathwaysQ34723561
Drosophila p53 preserves genomic stability by regulating cell deathQ34959692
The Jak/STAT pathway in model organisms: emerging roles in cell movementQ35024636
Border-cell migration: the race is on.Q35038279
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functionsQ35160263
Cell polarity: the ups and downs of the Par6/aPKC complexQ35187688
Composition and function of PDZ protein complexes during cell polarizationQ35188696
Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesisQ35192400
Understanding human cancer in a fly?Q35250030
Role of Rho-family proteins in cell adhesion and cancer.Q35547369
Branching morphogenesis of the Drosophila tracheal system.Q35564860
Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.Q35664007
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responsesQ35734639
The control of cell motility and epithelial morphogenesis by Jun kinasesQ35753182
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wingQ35787233
Parallels between tissue repair and embryo morphogenesisQ35805187
Germ cell specification and migration in Drosophila and beyondQ35842842
Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosisQ35842927
Drosophila, the golden bug, emerges as a tool for human geneticsQ35998774
Mechanisms of cancer cell invasionQ36015535
Ovarian cancer metastasis: integrating insights from disparate model organismsQ36111930
Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotypeQ36161077
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor ScribbleQ36322896
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in DrosophilaQ37367551
Fragile X protein functions with lgl and the par complex in flies and miceQ38332603
The genetics and epigenetics of neoplasms in DrosophilaQ39738061
Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growthQ40016536
The Drosophila cyclin D-Cdk4 complex promotes cellular growthQ40370724
DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in DrosophilaQ40442381
A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptorQ40612740
Notch activity in neural cells triggered by a mutant allele with altered glycosylation.Q40646738
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.Q40664929
Moesin functions antagonistically to the Rho pathway to maintain epithelial integrityQ40679590
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Distribution of Glut1 in detergent-resistant membranes (DRMs) and non-DRM domains: effect of treatment with azideQ42439535
Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancerQ42442321
The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless.Q42461234
The role of DE-cadherin during cellularization, germ layer formation and early neurogenesis in the Drosophila embryoQ42462757
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
Localization of apical epithelial determinants by the basolateral PDZ protein ScribbleQ42619733
Guidance of cell migration by the Drosophila PDGF/VEGF receptorQ43762442
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.Q43996886
Coupling cell growth, proliferation, and death. Hippo weighs in.Q44075775
Integrated activity of PDZ protein complexes regulates epithelial polarityQ44268189
Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (1(2)tid)Q44834458
Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosisQ44859699
A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye.Q45129152
Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic roleQ46222720
E2F-induced S phase requires cyclin E.Q46237378
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.Q46421007
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectDrosophila melanogasterQ130888
P304page(s)626-639
P577publication date2005-08-01
P1433published inNature Reviews CancerQ641657
P1476titleUsing Drosophila melanogaster to map human cancer pathways
P478volume5

Reverse relations

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