EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation

scientific article

EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00726-012-1277-Z
P932PMC publication ID3472071
P698PubMed publication ID22476347
P5875ResearchGate publication ID223958212

P2093author name stringYang Li
Ying Xiong
Junqi He
Zhiyu Yang
Duiping Feng
Longyan Yang
Weihua Bian
Renyou Zhai
Junfang Zheng
Wenfang Yao
P2860cites workEBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activityQ22001537
Direct interaction between NHERF1 and Frizzled regulates β-catenin signalingQ24298046
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signalingQ24303571
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinasesQ24305156
ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activationQ24320321
Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?Q24794064
EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinomaQ28182609
Human Delta1-pyrroline-5-carboxylate synthase: function and regulationQ28275915
Epidermal growth factor-related peptides and their receptors in human malignanciesQ28293442
Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.Q28368422
Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type ZQ28582156
Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesisQ28585214
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cellsQ28592252
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motilityQ30479197
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptorsQ33767107
The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1.Q34155123
EGFR signaling in breast cancer: bad to the bone.Q34348232
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activationQ34620786
Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)Q35633702
Contact-dependent inhibition of EGFR signaling by Nf2/MerlinQ36118464
Ezrin-radixin-moesin-binding phosphoprotein (EBP50), an estrogen-inducible scaffold protein, contributes to biliary epithelial cell proliferationQ37150777
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surfaceQ37657288
Predictive molecular markers of response to epidermal growth factor receptor(EGFR) family-targeted therapiesQ37780779
Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor functionQ38304289
Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathwaysQ39431960
Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells.Q39493807
Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroid carcinoma cells through suppression of EGFR/ERK pathway and cyclin B1/CDK1 complexQ39513352
Mutant rat strain lacking D-amino-acid oxidaseQ39948749
Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitorQ40077599
Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumorsQ40547930
E-cadherin binding modulates EGF receptor activationQ40606421
Protein tyrosine kinases and cancerQ41679383
NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancerQ45092731
The beta1-adrenergic receptor mediates extracellular signal-regulated kinase activation via GalphasQ46225959
Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cellsQ46439526
Investigating the function of three non-synonymous SNPs in EGFR gene: structural modelling and association with breast cancer.Q46891260
The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expressionQ48423163
Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptorsQ50335607
EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats.Q51886652
Elastase-released Epidermal Growth Factor Recruits Epidermal Growth Factor Receptor and Extracellular Signal-regulated Kinases to Down-regulate Tropoelastin mRNA in Lung FibroblastsQ62083049
P433issue5
P921main subjectphosphorylationQ242736
P304page(s)2027-2035
P577publication date2012-04-04
P1433published inAmino AcidsQ15757015
P1476titleEBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation
P478volume43

Reverse relations

cites work (P2860)
Q38902585A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy.
Q90273866Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers
Q43106592Clinical significance of EBP50 overexpression assessed by quantum dot analysis in gastric cancer
Q42197616Downregulation of PDZ Domain Containing 1 (PDZK1) is a Poor Prognostic Marker for Clear Cell Renal Cell Carcinoma
Q38966467EBP50 inhibits the migration and invasion of human breast cancer cells via LIMK/cofilin and the PI3K/Akt/mTOR/MMP signaling pathway
Q33962655EBP50 regulates the apoptosis of pancreatic cancer cells by decreasing the expression levels of Bcl-2.
Q47250144EBP50 suppresses the proliferation of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc.
Q26800001Insulin-like growth factor and epidermal growth factor signaling in breast cancer cell growth: focus on endocrine resistant disease
Q38505183Kinome Profiling of Regulatory T Cells: A Closer Look into a Complex Intracellular Network.
Q35128221Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes
Q37584289Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma
Q49894086NHERF1 Between Promises and Hopes: Overview on Cancer and Prospective Openings
Q55315464NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression.
Q54112426Na+/H+ exchanger regulatory factor 1 overexpression suppresses the malignant phenotype of MIAPaCa-2 pancreatic adenocarcinoma cells by downregulating Akt phosphorylation.
Q42654081PDZ-containing 1 acts as a suppressor of pancreatic cancer by regulating PTEN phosphorylation
Q33597837Reduced EBP50 expression levels are correlated with unfavorable clinicopathological features of extrahepatic bile duct carcinoma and promote the proliferation and migration of QBC939 cells
Q37295377Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins
Q55061344Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL).
Q39076960Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.
Q36808215SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells
Q36524074Targeting of NHERF1 through RNA interference inhibits the proliferation and migration of metastatic prostate cancer cells
Q98464897The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer

Search more.