| scholarly article | Q13442814 |
| P2093 | author name string | S Li | |
| H Rabinowich | |||
| X M Yin | |||
| A Gambotto | |||
| G Q Wang | |||
| B Fang | |||
| L A Goldstein | |||
| B R Gastman | |||
| A Rabinovitz | |||
| E Wieckowski | |||
| P2860 | cites work | tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c | Q24290118 |
| Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c | Q24309066 | ||
| Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors | Q24310559 | ||
| Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade | Q24311006 | ||
| DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis | Q24313625 | ||
| BID: a novel BH3 domain-only death agonist | Q24320091 | ||
| ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B | Q24321471 | ||
| Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 | Q24324482 | ||
| Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition | Q28115131 | ||
| Nuclear translocation of granzyme B in target cell apoptosis | Q73540343 | ||
| Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis | Q73679005 | ||
| Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection | Q73812485 | ||
| Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins | Q28117928 | ||
| A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD | Q28258328 | ||
| Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis | Q28270716 | ||
| Induction of apoptosis by the Bcl-2 homologue Bak | Q28299871 | ||
| Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis | Q28511080 | ||
| Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis | Q28512752 | ||
| Bax-deficient mice with lymphoid hyperplasia and male germ cell death | Q28589360 | ||
| Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice | Q28594763 | ||
| Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane | Q28647586 | ||
| Two CD95 (APO-1/Fas) signaling pathways | Q29619631 | ||
| Definition and redesign of the extended substrate specificity of granzyme B. | Q32003176 | ||
| CTL granules: evolution of vesicles essential for combating virus infections | Q33702139 | ||
| Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. | Q33898950 | ||
| Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin | Q33960986 | ||
| Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. | Q34139321 | ||
| Apoptotic pathways: the roads to ruin | Q34753431 | ||
| Regulated targeting of BAX to mitochondria. | Q36255507 | ||
| Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. | Q36368546 | ||
| Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. | Q36368577 | ||
| Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization. | Q36376867 | ||
| Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes | Q36704066 | ||
| Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis | Q38326924 | ||
| A role for mitochondrial Bak in apoptotic response to anticancer drugs | Q40793451 | ||
| Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition | Q40837904 | ||
| Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. | Q40841876 | ||
| Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route | Q40843079 | ||
| DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis | Q40868557 | ||
| Adenoviral Bak overexpression mediates caspase-dependent tumor killing | Q40895542 | ||
| Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery | Q41056260 | ||
| Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. | Q41284156 | ||
| Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity | Q41699947 | ||
| Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway | Q43559474 | ||
| 10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria | Q43670813 | ||
| Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. | Q47781476 | ||
| Granzyme A initiates an alternative pathway for granule-mediated apoptosis. | Q54013097 | ||
| Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications. | Q54085818 | ||
| Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. | Q54515149 | ||
| Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis | Q57272488 | ||
| Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent | Q57272605 | ||
| Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes | Q57272612 | ||
| Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis | Q58235025 | ||
| New Paradigm for Lymphocyte Granule-mediated Cytotoxicity | Q59156993 | ||
| Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3 | Q59156995 | ||
| New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis | Q64382665 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1325-1337 | |
| P577 | publication date | 2001-11-01 | |
| P1433 | published in | Journal of Experimental Medicine | Q3186912 |
| P1476 | title | Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells | |
| P478 | volume | 194 |
| Q21261236 | BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells |
| Q42667002 | Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation |
| Q41889229 | Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum |
| Q35918372 | Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release |
| Q50733554 | Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. |
| Q28546869 | Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound |
| Q64109935 | Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 |
| Q34716318 | Cytotoxic T lymphocytes: all roads lead to death |
| Q34588821 | Death by a thousand cuts: granzyme pathways of programmed cell death |
| Q34741839 | Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. |
| Q44795441 | Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events |
| Q33991174 | Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage |
| Q43902939 | Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells |
| Q79479603 | Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: implications for HIV immunopathogenesis |
| Q45267238 | Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis |
| Q91725847 | E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2 |
| Q35583498 | Effector mechanisms in transplant rejection |
| Q42638938 | Fowlpox virus encodes a Bcl-2 homologue that protects cells from apoptotic death through interaction with the proapoptotic protein Bak. |
| Q41982710 | Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death |
| Q39668303 | Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death |
| Q36325018 | Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis |
| Q30152650 | Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis. |
| Q39396823 | Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition |
| Q34263689 | Granzyme B: pro-apoptotic, antiviral and antitumor functions |
| Q35150716 | Nonredundant role of Bax and Bak in Bid-mediated apoptosis |
| Q33990989 | Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim. |
| Q46988935 | Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2. |
| Q36363353 | Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins. |
| Q35136000 | The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal |
| Q37247956 | The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis |
| Q90196924 | The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy |
| Q37564741 | The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease |
| Q39611834 | The vaccinia virus F1L protein interacts with the proapoptotic protein Bak and inhibits Bak activation |
| Q35839831 | Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function |
| Q34454210 | Unique and overlapping substrate specificities of caspase-8 and caspase-10. |
| Q39539847 | Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. |
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