A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

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A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1001710005
P356DOI10.1038/NATURE11352
P932PMC publication ID3509936
P698PubMed publication ID22810588
P5875ResearchGate publication ID229322585

P50authorJudith KimbleQ15709502
Scott G. KennedyQ73167504
P2093author name stringHeidi Fritz
Scott Kennedy
Sam Guoping Gu
Andrew Fire
Aaron Kershner
George Spracklin
Kirk B Burkhart
Bethany A Buckley
P2860cites workTransgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and EvolutionQ22066105
A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulationQ27336267
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
Epigenetic reprogramming in mammalian developmentQ28212171
The rde-1 gene, RNA interference, and transposon silencing in C. elegansQ29618386
Genetic requirements for inheritance of RNAi in C. elegansQ33896202
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegansQ34137901
Gene expression: long-term gene silencing by RNAiQ34560044
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAiQ34582311
Distinct populations of primary and secondary effectors during RNAi in C. elegansQ34584272
Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.Q35621398
piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegansQ36298021
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germlineQ36684944
Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegansQ36969541
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprintQ37359550
Function, targets, and evolution of Caenorhabditis elegans piRNAsQ37633703
An Argonaute transports siRNAs from the cytoplasm to the nucleus.Q39752627
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.Q41473315
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germlineQ42219455
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegansQ47068702
Characterization of a germ-line proliferation mutation in C. elegansQ67817522
P433issue7416
P407language of work or nameEnglishQ1860
P921main subjectHeritable RNAi Deficient CELE_C16C10.3Q29802630
P304page(s)447-451
P577publication date2012-07-18
P1433published inNatureQ180445
P1476titleA nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality
P478volume489

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cites work (P2860)
Q37409330A Multigenic Network of ARGONAUTE4 Clade Members Controls Early Megaspore Formation in Arabidopsis.
Q49886624A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans
Q36782763A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions
Q93253703A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
Q38157699A multitasking Argonaute: exploring the many facets of C. elegans CSR-1.
Q37633450A nuclear perspective on RNAi pathways in metazoans
Q35054174A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi
Q33574854A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress
Q36466883A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans
Q37016037A twist of fate: How a meiotic protein is providing new perspectives on germ cell development.
Q92541143AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway
Q89840603Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk
Q40508050Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans
Q38111603Argonaute proteins: functional insights and emerging roles
Q34393505Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans
Q41299732Assays for direct and indirect effects of C. elegans endo-siRNAs
Q34544412Bidirectional Transfer of RNAi between Honey Bee and Varroa destructor: Varroa Gene Silencing Reduces Varroa Population
Q26825523Bridging the transgenerational gap with epigenetic memory
Q33910575C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility
Q38170221C. elegans epigenetic regulation in development and aging
Q93274049C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing
Q34384139Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations
Q98507748Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3
Q48911542Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks
Q64957535Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans.
Q46316443Chromatin-associated noncoding RNAs in development and inheritance
Q35201304Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans
Q91738893Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
Q98725915DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
Q37644161Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans
Q37601449Delayed development induced by toxicity to the host can be inherited by a bacterial-dependent, transgenerational effect
Q37593653Demystifying the nuclear function of Argonaute proteins.
Q41562514Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation.
Q35128832Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing
Q38192541Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance?
Q34758207Endogenous nuclear RNAi mediates behavioral adaptation to odor.
Q90226498Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs
Q33554228Epigenetic control of mobile DNA as an interface between experience and genome change
Q38970274Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications
Q26858848Epigenetic inheritance of metabolic state
Q28066862Epigenetic inheritance of proteostasis and ageing
Q34513596Epigenetic mechanisms and models in the origins of asthma
Q36531421Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Q36449546Epigenetic: a molecular link between testicular cancer and environmental exposures
Q26853555Epigenetics: the fine-tuner in inflammatory bowel disease?
Q99637281Epimutations driven by small RNAs arise frequently but most have limited duration in Caenorhabditis elegans
Q34551032Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence
Q37398041Extracellular RNA is transported from one generation to the next in Caenorhabditis elegans
Q36166738Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans
Q63740281Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease
Q38288095From early lessons to new frontiers: the worm as a treasure trove of small RNA biology
Q64230301Function and Evolution of Nematode RNAi Pathways
Q57682999GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in
Q90006461Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference
Q35534936Genome-wide profiling of the C. elegans dsRNAome
Q38077445Genotype to phenotype: lessons from model organisms for human genetics
Q92396539Germ Granules Govern Small RNA Inheritance
Q33797064Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape
Q38162646Guest list or black list: heritable small RNAs as immunogenic memories
Q64092600H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes
Q37591542Homeland security in the C. elegans germ line: insights into the biogenesis and function of piRNAs
Q86583305How epigenetic mutations can affect genetic evolution: Model and mechanism
Q64883258Inter-generational consequences for growing Caenorhabditis elegans in liquid.
Q50150212Intergenerational Transmission of Gene Regulatory Information in Caenorhabditis elegans
Q90854193Intergenerational and transgenerational epigenetic inheritance in animals
Q33816778Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response
Q36763225Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models
Q92875181Interplay between small RNA pathways shapes chromatin landscapes in C. elegans
Q57083956Is There Social RNA?
Q64993308Isolated C. elegans germ nuclei exhibit distinct genomic profiles of histone modification and gene expression.
Q36282697JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity
Q38950807Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans
Q21129357Lamarckian evolution explains human brain evolution and psychiatric disorders
Q46543801MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality
Q37008671Male fertility: Is spermiogenesis the critical step for answering biomedical issues?
Q37253449Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
Q38215233MicroRNA-dependent genetic networks during neural development
Q41960922MicroRNAs micromanage themselves
Q30371599Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds
Q45935781Molecular biology. Is there social RNA?
Q92954247Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications
Q36559951Mutation of C. elegans demethylase spr-5 extends transgenerational longevity
Q36972571Natural RNA interference directs a heritable response to the environment
Q26849700Nematode endogenous small RNA pathways
Q92614149Neuronal Small RNAs Control Behavior Transgenerationally
Q35776105Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports
Q98718620Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans
Q37471101Nuclear Noncoding RNAs and Genome Stability.
Q33575741Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans
Q92417839PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability
Q39422553PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans
Q38116797PIWI-interacting RNAs: from generation to transgenerational epigenetics
Q59350769PIWI-interacting RNAs: small RNAs with big functions
Q33588098PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans
Q38982408Paramutation and related phenomena in diverse species
Q34332378Paternal RNA contributions in the Caenorhabditis elegans zygote
Q42006214Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice
Q34593170Piwi Proteins and piRNAs step onto the systems biology stage
Q29544165Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
Q37551776Plastic germline reprogramming of heritable small RNAs enables maintenance or erasure of epigenetic memories
Q27345396Protease-dead separase is dominant negative in the C. elegans embryo
Q26781830RNA-based regulation of transposon expression
Q35223649RNA-mediated epigenetic regulation of gene expression
Q35147647RNA: a possible contributor to the 'missing heritability'.
Q38559905RNAi and heterochromatin assembly
Q90428483RNAi pathways repress reprogramming of C. elegans germ cells during heat stress
Q48272919RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway.
Q33724795Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants
Q50687953Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies
Q38222353Regulation of histone methylation by noncoding RNAs
Q52729661Replicating and Cycling Stores of Information Perpetuate Life
Q38516157Repression of somatic cell fate in the germline
Q48148054Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function
Q35857342Roll over Weismann: extracellular vesicles in the transgenerational transmission of environmental effects
Q64966505SID-1 Functions in Multiple Roles To Support Parental RNAi in Caenorhabditis elegans.
Q36750392Silencing of germline-expressed genes by DNA elimination in somatic cells
Q42881075Silent no more: Endogenous small RNA pathways promote gene expression
Q34561346Small RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
Q38232933Small RNAs break out: the molecular cell biology of mobile small RNAs
Q38101709Small RNAs, RNAi and the Inheritance of Gene Silencing in Caenorhabditis elegans
Q89518731Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants
Q41401729SnapShot: Small RNA-Mediated Epigenetic Modifi cations
Q59066160Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance.
Q51133234Stable Heritable Germline Silencing Directs Somatic Silencing at an Endogenous Locus
Q34428939Starvation-induced transgenerational inheritance of small RNAs in C. elegans.
Q39094256Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs
Q47988407Switches in Dicer Activity During Oogenesis and Early Development
Q27311391Tertiary siRNAs mediate paramutation in C. elegans
Q34393555The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression
Q41373535The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.
Q92723796The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome
Q40467594The RNA-induced transcriptional silencing complex targets chromatin exclusively via interacting with nascent transcripts.
Q50987178The RNAi Inheritance Machinery of Caenorhabditis elegans
Q61455477The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in . e
Q57283475The balance of poly(U) polymerase activity ensures germline identity, survival and development in
Q34991967The elucidation of stress memory inheritance in Brassica rapa plants
Q64108584The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing
Q36784726The nuclear argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans
Q48506312The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes
Q22121998The rise of regulatory RNA
Q28080133The roles of microRNAs and siRNAs in mammalian spermatogenesis
Q41271770The soft genome
Q57802373The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in
Q64265980Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment
Q92726341Transcriptional adaptation in Caenorhabditis elegans
Q36417645Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression
Q90520296Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans
Q58616305Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein
Q64113217Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins SET-25 and SET-32
Q91807757Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development
Q57164370Transgenerational and intergenerational epigenetic inheritance in allergic diseases
Q38586384Transgenerational epigenetic inheritance: adaptation through the germline epigenome?
Q38582112Transgenerational epigenetic inheritance: an open discussion
Q33606597Transgenerational epigenetic inheritance: myths and mechanisms
Q37681231Transgenerational epigenetics in the germline cycle of Caenorhabditis elegans
Q38155776Transgenerational functions of small RNA pathways in controlling gene expression in C. elegans
Q38108665Transgenerational inheritance of non-genetically determined phenotypes
Q39009429Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance
Q38761365Transgenerational response to stress in plants and its application for breeding
Q93112474Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase
Q47164904Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
Q38641096Use / disuse paradigms are ubiquitous concepts in characterizing the process of inheritance
Q92224337Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans
Q57753918ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals
Q91691773henn-1/HEN1 Promotes Germline Immortality in Caenorhabditis elegans
Q28392701piRNA involvement in genome stability and human cancer
Q35998286piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway
Q96136787poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

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