Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function

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Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function is …
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P356DOI10.1534/GENETICS.117.300386
P932PMC publication ID5788517
P698PubMed publication ID29378810

P50authorJulie AhringerQ15709495
Susan M. GasserQ21062334
P2860cites workA role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombinationQ21144893
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiationQ24302015
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardationQ24304870
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylasesQ24315937
HP1a: a structural chromosomal protein regulating transcriptionQ27021442
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegansQ27318351
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24Q27331769
H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensationQ27331824
The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activityQ27334177
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin RegulationQ39682740
An Argonaute transports siRNAs from the cytoplasm to the nucleus.Q39752627
HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomainQ39777525
The spatial dynamics of tissue-specific promoters during C. elegans developmentQ40014678
Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.Q40274527
Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genomeQ40784286
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.Q41473315
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.Q41735227
Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cellsQ41960310
Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types.Q42426927
Systematic identification of methyllysine-driven interactions for histone and nonhistone targetsQ42909185
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factorsQ42951883
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during developmentQ43015490
The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.Q43115568
HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcriptsQ43908593
MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline ImmortalityQ46543801
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans developmentQ46925893
The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegansQ47068688
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.Q47068818
The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval developmentQ47068972
Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval developmentQ47069021
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination.Q47069081
Unique and redundant functions of C. elegans HP1 proteins in post-embryonic developmentQ47069207
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegansQ47069337
Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegansQ47069385
Perinuclear distribution of heterochromatin in developing C. elegans embryosQ47069593
Whole-genome sequencing and variant discovery in C. elegans.Q47595683
Transgenerational transmission of environmental information in C. elegansQ48251389
Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.Q50278958
Lamin-Binding Proteins in Caenorhabditis elegans.Q50540028
The RNAi Inheritance Machinery of Caenorhabditis elegans.Q50987178
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.Q52043143
Polycomb group regulation of Hox gene expression in C. elegans.Q52104494
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.Q52236554
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.Q53284482
Repetitive Transgenes in C. elegans Accumulate Heterochromatic Marks and Are Sequestered at the Nuclear Envelope in a Copy-Number- and Lamin-Dependent MannerQ61275222
The kinetochores of Caenorhabditis elegansQ70598101
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegansQ83296442
The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegansQ86127390
Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin.Q37053228
HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cellsQ37102700
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.Q37125884
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memoryQ37166371
Heterochromatin protein 1 is recruited to various types of DNA damage.Q37263966
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprintQ37359550
The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear peripheryQ37379029
Stable Caenorhabditis elegans chromatin domains separate broadly expressed and developmentally regulated genesQ37417986
Regulation of the X chromosomes in Caenorhabditis elegansQ37618160
Function, targets, and evolution of Caenorhabditis elegans piRNAsQ37633703
Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegansQ37644161
Caenorhabditis elegans as a model system for studying the nuclear lamina and laminopathic diseasesQ37942334
Recognition of methylated histones: new twists and variationsQ37953134
Molecular mechanisms and potential functions of histone demethylasesQ37999690
What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memoryQ38206369
Dynamic changes of histone H3 marks during Caenorhabditis elegans lifecycle revealed by middle-down proteomicsQ38401337
New Insights into the Regulation of HeterochromatinQ38785509
Epigenetic balance of gene expression by Polycomb and COMPASS familiesQ38852455
JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signalingQ38996548
H3K27 methylation: a promiscuous repressive chromatin markQ39035286
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexesQ27334718
A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulationQ27336267
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9Q27638208
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsQ27641772
Role of the polycomb protein EED in the propagation of repressive histone marksQ27657483
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)Q27665361
Histone methylation by PRC2 is inhibited by active chromatin marksQ27667743
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteinsQ27860456
Genome sequence of the nematode C. elegans: a platform for investigating biologyQ27860527
Constitutive heterochromatin formation and transcription in mammalsQ28080683
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
The histone demethylase UTX enables RB-dependent cell fate controlQ28272073
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Different Mi-2 complexes for various developmental functions in Caenorhabditis elegansQ28475938
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva developmentQ28477443
Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neuronsQ28828201
Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutQ29301233
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickersQ29547350
JmjC-domain-containing proteins and histone demethylationQ29614517
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assemblyQ29614718
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegansQ29616062
The Dfam database of repetitive DNA familiesQ30488601
Heterochromatic genome stability requires regulators of histone H3 K9 methylationQ33422980
Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ lineQ33526991
A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stressQ33574854
A histone methylation network regulates transgenerational epigenetic memory in C. elegansQ33576338
Partitioning the C. elegans genome by nucleosome modification, occupancy, and positioningQ33587754
The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny.Q33686906
Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutantsQ33724795
Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.Q33741805
A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval developmentQ33757634
DNA replication and transcription programs respond to the same chromatin cues.Q33839410
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.Q33842527
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repairQ33862272
Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegansQ33899619
Anchoring of Heterochromatin to the Nuclear Lamina Reinforces Dosage Compensation-Mediated Gene Repression.Q36150010
Extremely stable Piwi-induced gene silencing in Caenorhabditis elegansQ36166738
piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegansQ36298021
A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortalityQ36433534
A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegansQ36466883
An inverse relationship to germline transcription defines centromeric chromatin in C. elegansQ36511978
Mutation of C. elegans demethylase spr-5 extends transgenerational longevityQ36559951
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegansQ36676559
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germlineQ36684944
Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin AssemblyQ36687330
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.Q36731942
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegansQ36943578
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced LongevityQ36956854
Gene regulation through nuclear organization.Q36994161
Position-effect variegation, heterochromatin formation, and gene silencing in DrosophilaQ37040262
The epigenetics of germ-line immortality: lessons from an elegant model systemQ33903484
Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegansQ33958810
Structural and functional dynamics of human centromeric chromatinQ33996546
Targeting X chromosomes for repressionQ34003258
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesisQ34011879
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germlineQ34012402
DNA Methylation on N6-Adenine in C. elegansQ34043905
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexesQ34059541
Nuclear compartmentalization and gene activityQ34186324
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alphaQ34196189
R loops: from transcription byproducts to threats to genome stabilityQ34271508
Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatinQ34297995
Comparative analysis of metazoan chromatin organizationQ34486035
Broad chromosomal domains of histone modification patterns in C. elegansQ34548272
Genomics in C. elegans: so many genes, such a little wormQ34563189
synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survivalQ34592502
Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motifQ34609776
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2Q34613778
Trans-generational epigenetic regulation of C. elegans primordial germ cellsQ34622455
H3K36 methylation antagonizes PRC2-mediated H3K27 methylationQ34624209
The role of the Arabidopsis Exosome in siRNA-independent silencing of heterochromatic loci.Q34650027
Structures of SET domain proteins: protein lysine methyltransferases make their markQ34952892
A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination.Q35326686
HP1 and the dynamics of heterochromatin maintenanceQ35741016
High evolutionary turnover of satellite families in Caenorhabditis.Q35799797
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegansQ35836441
LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processesQ35844907
"Holo"er than thou: chromosome segregation and kinetochore function in C. elegansQ35853959
Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolismQ35907679
A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombeQ35927018
Heterochromatin protein 1, a known suppressor of position-effect variegation, is highly conserved in DrosophilaQ35935207
The SynMuv genes of Caenorhabditis elegans in vulval development and beyondQ35955994
C. elegans piRNAs mediate the genome-wide surveillance of germline transcriptsQ36136040
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectCaenorhabditis elegansQ91703
chromatinQ180951
P1104number of pages21
P304page(s)491-511
P577publication date2018-02-01
P1433published inGeneticsQ3100575
P1476titleRepressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function
P478volume208

Reverse relations

cites work (P2860)
Q92227197Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei
Q100395116Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development
Q90082889C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development
Q83225257Diversification of the heat shock response by Helitron transposable elements
Q64923274H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans.
Q64901368Histone Methylation and Memory of Environmental Stress.
Q97874483Histone methyltransferase activity programs nuclear peripheral genome positioning
Q91595909LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay
Q89916726Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos
Q92060510Mapping the dsRNA World
Q64055118Repression of Germline Genes in Somatic Tissues by H3K9 Dimethylation of Their Promoters
Q90193835The Epigenetics of Aging in Invertebrates

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