Functional characterization of the transactivation properties of the PDX-1 homeodomain protein

scientific article published on July 1997

Functional characterization of the transactivation properties of the PDX-1 homeodomain protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.7.3987
P932PMC publication ID232251
P698PubMed publication ID9199333

P2093author name stringR Stein
A Sharma
E Henderson
C V Wright
M Peshavaria
P2860cites workTwo distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motifQ24305878
Sequence of the cDNA encoding ITF-1, a positive-acting transcription factorQ24633686
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptorsQ27860552
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expressionQ28115311
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzymeQ28275910
The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient miceQ28513142
The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomainQ28574370
Firefly luciferase gene: structure and expression in mammalian cellsQ29616519
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenumQ29618151
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix proteinQ29618504
The insulin gene promoter. A simplified nomenclatureQ48789347
Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.Q51128200
Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8.Q52206427
Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.Q52251957
The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.Q52541323
Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormonesQ67521588
Insulin cells of pancreas extend neurites but do not arise from the neuroectodermQ67677100
A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferaseQ68760342
Structure and evolution of the insulin geneQ69924638
XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factorQ72740560
Insulin-promoter-factor 1 is required for pancreas development in miceQ29619695
Transcription activation by the adenovirus E1a proteinQ29620538
Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin EnhancerQ33263393
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimersQ33332420
Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogeneQ33679093
Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expressionQ33886988
Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cellsQ34290753
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancerQ34375782
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factorQ34407862
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxesQ35856801
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promotersQ36268104
The E2A gene product contains two separable and functionally distinct transcription activation domainsQ36507951
The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cellsQ36556697
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expressionQ36645030
A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cellsQ36660430
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factorQ36706855
Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box.Q36723820
Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequenceQ36755529
Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elementsQ36758591
Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cellsQ36764691
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activityQ36783092
Onset of cell-specific gene expression in the developing mouse pancreasQ36822712
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteinsQ36961228
Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1Q37382028
IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin geneQ37629612
Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent mannerQ38303384
Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription.Q38311840
Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoterQ38362801
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytesQ40505363
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexesQ40678585
IPF1, a homeodomain-containing transactivator of the insulin geneQ40874284
The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing CellsQ41067572
The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cellsQ41156786
The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.Q41295233
Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II geneQ41665716
The midgestational human fetal pancreas contains cells coexpressing islet hormonesQ42453451
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiationQ42808711
Ultrastructural studies of early morphogenesis and cytodifferentiation in the embryonic mammalian pancreasQ45228648
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.Q46446650
extradenticle raises the DNA binding specificity of homeotic selector gene productsQ46446845
Characterization of the two nonallelic genes encoding mouse preproinsulinQ48370767
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3987-3996
P577publication date1997-07-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleFunctional characterization of the transactivation properties of the PDX-1 homeodomain protein
P478volume17

Reverse relations

cites work (P2860)
Q30441221A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis
Q40602787Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression
Q40218659Amino acid 1-209 is essential for PDX-1-mediated repression of human CMV IE promoter activity
Q40478891Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy.
Q28591464DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex
Q24562726Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
Q40239436Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures
Q37497514Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro.
Q40675167Experimental conversion of liver to pancreas
Q24631284Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease
Q37237607Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease.
Q28566461Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization
Q41014247Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor
Q24297588ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells
Q24567626Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity
Q39449324Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas
Q40657679Induction of Mad expression leads to augmentation of insulin gene transcription
Q24540063Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
Q24563557Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
Q42594814Novel pattern of AtXlox gene expression in starfish Archaster typicus embryos
Q38359562Overexpression of the Pdx-1 homeodomain transcription factor impairs glucose metabolism in cultured rat hepatocytes.
Q36951907PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter
Q38887124PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells
Q47888790Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites
Q28566577Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer
Q28573262Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation
Q34967266Regulation of gene promoters of hypothalamic peptides
Q33963287Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.
Q40429175Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter
Q44744692Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter
Q33964485Specific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family
Q42856791Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).
Q40811956The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation
Q28507859The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription
Q33957229The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding
Q33680353The Pancreatic and Duodenal Homeobox Protein PDX-1 Regulates the Ductal Specific Keratin 19 through the Degradation of MEIS1 and DNA Binding
Q39450757The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
Q38322223The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS.
Q28609099Transcription factors direct the development and function of pancreatic beta cells
Q40850468Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression
Q35185531Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function.
Q33786590p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

Search more.