Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression

scientific article published on 30 December 2003

Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M307577200
P698PubMed publication ID14701848

P2093author name stringMin Guo
Roland Stein
Yi Qiu
Suming Huang
P2860cites workMutations in NEUROD1 are associated with the development of type 2 diabetes mellitusQ22010745
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient miceQ24314353
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1AQ24336667
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Q24540063
Regulation of transcription factor YY1 by acetylation and deacetylationQ24550859
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
Histone acetylation in chromatin structure and transcriptionQ28131749
Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activatorQ28145350
Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreasQ59070691
A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferaseQ68760342
The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, TatQ28198162
Regulation of insulin gene transcriptionQ28210255
Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsyQ28510873
The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cellsQ28512414
NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampusQ28584879
Histone acetylation and transcriptional regulatory mechanismsQ29547707
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
Firefly luciferase gene: structure and expression in mammalian cellsQ29616519
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix proteinQ29618504
Insulin-promoter-factor 1 is required for pancreas development in miceQ29619695
Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin EnhancerQ33263393
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin geneQ33786590
CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sitesQ33957911
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancerQ34375782
P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCLQ34684061
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxesQ35856801
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferasesQ36278311
The E2A gene product contains two separable and functionally distinct transcription activation domainsQ36507951
Functional characterization of the transactivation properties of the PDX-1 homeodomain proteinQ36569313
A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cellsQ36660430
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factorQ36706855
A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cellsQ36728990
Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequenceQ36755529
Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elementsQ36758591
Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene productsQ36762817
Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cellsQ36764691
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteinsQ36961228
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complexQ39458728
Regulation of E2F1 activity by acetylationQ40387087
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetesQ40444628
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexesQ40678585
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle programQ40908837
Targeting chromatin disruption: Transcription regulators that acetylate histonesQ40970395
The beta cell transcription factors and development of the pancreasQ41496269
Acetylation of general transcription factors by histone acetyltransferasesQ41586010
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoformsQ41729392
HIV-1 tat transcriptional activity is regulated by acetylationQ42163503
Regulation of activity of the transcription factor GATA-1 by acetylationQ42823439
MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1.Q43806860
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet developmentQ44055107
Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosomeQ44646118
The p300/CBP family: integrating signals with transcription factors and chromatinQ45155861
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P1104number of pages7
P304page(s)9796-9802
P577publication date2003-12-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleAcetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression
P478volume279

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cites work (P2860)
Q35651147A small molecule differentiation inducer increases insulin production by pancreatic β cells
Q40182379All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation
Q39004147CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells
Q36173644Glucose mediates the translocation of NeuroD1 by O-linked glycosylation
Q30418321Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets
Q37832964Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus
Q24322398Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription
Q30436101Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
Q30439989Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene
Q39503798Regulation of insulin gene transcription by multiple histone acetyltransferases
Q34420184Role of histone and transcription factor acetylation in diabetes pathogenesis

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