AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2

scientific article published on July 2003

AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6601037
P932PMC publication ID2394257
P698PubMed publication ID12865934
P5875ResearchGate publication ID10657813

P2093author name stringS Virudachalam
R J Bold
B N Fahy
M Schlieman
P2860cites workQuantitative prediction of NF-kappa B DNA-protein interactionsQ24298906
NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosisQ24554454
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.Q33783562
Phosphoinositide 3-kinase signalling pathwaysQ33940898
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancerQ33950784
Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survivalQ33959533
The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).Q33962748
Use of kinase inhibitors to dissect signaling pathways.Q33979180
Ten years of protein kinase B signalling: a hard Akt to followQ34432885
Present and future treatment of pancreatic cancerQ34718249
Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 statusQ36691968
The akt kinase: molecular determinants of oncogenicityQ36758478
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.Q38467361
Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabineQ40680294
NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosisQ40717021
NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cellsQ40729431
Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factorQ40732071
Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancerQ40769199
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membraneQ40816351
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.Q40831748
Rel/NF-kappaB represses bcl-2 transcription in pro-B lymphocytes.Q40882464
Phosphatidylinositol 3'-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors.Q40960813
Identification of a p53-dependent negative response element in the bcl-2 geneQ41461046
Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicinQ42503199
Role of Akt in growth and survival of PANC-1 pancreatic cancer cellsQ43821002
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivoQ44248593
Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 contentQ45858399
The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neuronsQ48563846
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.Q54033430
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cellsQ64379556
Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neuronsQ64381195
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTENQ64381461
Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: effects on clinical outcome and efficacy of adjuvant chemotherapyQ73688006
Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependentQ73712391
Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathwaysQ74232608
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cellsQ77904111
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
cancer cell lineQ23058136
P304page(s)391-397
P577publication date2003-07-01
P1433published inBritish Journal of CancerQ326309
P1476titleAKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
P478volume89

Reverse relations

cites work (P2860)
Q28486199Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae
Q36835642Apoptotic pathways in pancreatic ductal adenocarcinoma
Q35100914Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation
Q36182734Clusterin silencing sensitizes pancreatic cancer MIA-PaCa-2 cells to gmcitabine via regulation of NF-kB/Bcl-2 signaling
Q41270773Combination of celecoxib (Celebrex®) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas
Q33792279Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells
Q38946429Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies
Q35578720Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway
Q39535549FKBP51 protects 661w cell culture from staurosporine-induced apoptosis.
Q28484635Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53
Q34384695Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway
Q38727311Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression.
Q34721443High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma
Q36648105Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
Q35719620Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-κB signaling pathway in human pancreatic ductal adenocarcinoma
Q40457650Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions.
Q40206683Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma
Q40435304Modulation of tamoxifen sensitivity by antisense Bcl-2 and trastuzumab in breast carcinoma cells
Q35741836Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation
Q34680322Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.
Q38812160New Treatment of Medullary and Papillary Human Thyroid Cancer: Biological Effects of Hyaluronic Acid Hydrogel Loaded With Quercetin Alone or in Combination to an Inhibitor of Aurora Kinase.
Q53700817Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10.
Q40181453PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway
Q30499567Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
Q58586943Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol
Q40213093Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB.
Q41682526RLN2 Is a Positive Regulator of AKT-2-Induced Gene Expression Required for Osteosarcoma Cells Invasion and Chemoresistance
Q37324457RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance
Q40615849RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity
Q45099758Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen
Q39025559Role of autophagy in apoptotic regulation by Akt in pancreatic cancer
Q35954519Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents
Q37030872Targeting synuclein-gamma to counteract drug resistance in cancer
Q40507359The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
Q42991719The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance
Q34494019The molecular targets for the diagnosis and treatment of pancreatic cancer
Q35983641The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.
Q36020360The role of Akt activation in the response to chemotherapy in pancreatic cancer
Q36773130The role of chemoradiation for patients with resectable or potentially resectable pancreatic cancer
Q93046345Therapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma
Q81285585[Pathogenesis of the ductal pancreatic adenocarcinoma: implications for future therapies?]
Q37448131miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NFκB.

Search more.