| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.STEMCR.2016.01.013 |
| P8608 | Fatcat ID | release_holgp6b2zzb4ngcaio25babcdy |
| P932 | PMC publication ID | 4788783 |
| P698 | PubMed publication ID | 26905200 |
| P5875 | ResearchGate publication ID | 295078677 |
| P50 | author | Sally A. Cowley | Q48356810 |
| George K Tofaris | Q56056700 | ||
| Brent J Ryan | Q56438375 | ||
| Kevin Talbot | Q56841861 | ||
| William James | Q58304474 | ||
| Hugo J Ribeiro Fernandes | Q59699664 | ||
| Richard Wade-Martins | Q60537481 | ||
| Michele T M Hu | Q64857486 | ||
| Helen Christian | Q71317863 | ||
| P2093 | author name string | Ying Zheng | |
| S Pablo Sardi | |||
| Kostas Vekrellis | |||
| Charmaine Lang | |||
| Heather Booth | |||
| Jane Vowles | |||
| Helle Bogetofte | |||
| Samuel Evetts | |||
| Elizabeth M Hartfield | |||
| Evangelia Emmanoulidou | |||
| Jennifer Badger | |||
| P2860 | cites work | Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease | Q21144949 |
| Guidelines for the use and interpretation of assays for monitoring autophagy | Q21996341 | ||
| LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase | Q24300793 | ||
| Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies | Q24307627 | ||
| Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. | Q24634577 | ||
| Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein | Q24655848 | ||
| LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model | Q24656256 | ||
| Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models | Q24683059 | ||
| Activity‐dependent secretion of alpha‐synuclein by enteric neurons | Q44170859 | ||
| Parkinson patient fibroblasts show increased alpha-synuclein expression | Q45780402 | ||
| Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses | Q48134927 | ||
| Glucocerebrosidase mutations are an important risk factor for Lewy body disorders | Q48491146 | ||
| iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis | Q48729780 | ||
| Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population | Q57695591 | ||
| Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis | Q27323098 | ||
| Physiological characterisation of human iPS-derived dopaminergic neurons | Q27324718 | ||
| Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells | Q28308084 | ||
| Assessment of α-synuclein secretion in mouse and human brain parenchyma | Q28479033 | ||
| Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy | Q29614178 | ||
| A bioinformatic assay for pluripotency in human cells | Q30484872 | ||
| Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species | Q33360061 | ||
| Progress toward the clinical application of patient-specific pluripotent stem cells | Q33559694 | ||
| Altered lipid content inhibits autophagic vesicular fusion | Q34017069 | ||
| X-ray and biochemical analysis of N370S mutant human acid β-glucosidase. | Q34452544 | ||
| Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions | Q34948733 | ||
| CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy | Q35122963 | ||
| Parkinsonism among Gaucher disease carriers | Q35444509 | ||
| Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential | Q35614922 | ||
| Endoplasmic reticulum stress triggers autophagy | Q35690087 | ||
| Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway | Q36043181 | ||
| Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains | Q36801004 | ||
| Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. | Q36870862 | ||
| Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. | Q36907208 | ||
| Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion | Q36928990 | ||
| A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies | Q37346468 | ||
| Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival | Q37347595 | ||
| Lysosome-dependent pathways as a unifying theme in Parkinson's disease. | Q38038561 | ||
| Cellular reprogramming: a new approach to modelling Parkinson's disease. | Q38044447 | ||
| The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity | Q38968679 | ||
| Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. | Q39595928 | ||
| Pathogenic lysosomal depletion in Parkinson's disease | Q39655523 | ||
| Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis. | Q39751424 | ||
| Identification of distinct circulating exosomes in Parkinson's disease | Q39760969 | ||
| Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. | Q40405368 | ||
| A clinical and family history study of Parkinson's disease in heterozygous glucocerebrosidase mutation carriers | Q42493495 | ||
| Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: novel considerations. | Q42614444 | ||
| Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions | Q43117414 | ||
| P4510 | describes a project that uses | UOXFi001-A | Q54991432 |
| UOXFi001-B | Q54991433 | ||
| UOXFi003-A | Q54991439 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Parkinson's disease | Q11085 |
| autophagy | Q288322 | ||
| cell line | Q21014462 | ||
| Synuclein | Q24767155 | ||
| P304 | page(s) | 342-356 | |
| P577 | publication date | 2016-02-18 | |
| P1433 | published in | Stem Cell Reports | Q27725039 |
| P1476 | title | ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons | |
| P478 | volume | 6 |
| Q96304526 | "LRRK2: Autophagy and Lysosomal Activity" |
| Q47157967 | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease. |
| Q37445013 | A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin |
| Q37096051 | A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism |
| Q92593882 | A compendious summary of Parkinson's disease patient-derived iPSCs in the first decade |
| Q37235303 | A novel real time imaging platform to quantify macrophage phagocytosis |
| Q47289706 | Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation |
| Q89834776 | Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses |
| Q37528927 | Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease |
| Q89729152 | Autophagy in Parkinson's Disease |
| Q53820272 | Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation. |
| Q37164667 | C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal |
| Q100307062 | CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease |
| Q50338475 | Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. |
| Q64956244 | Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons. |
| Q55071517 | Centrality of Early Synaptopathy in Parkinson's Disease. |
| Q41918838 | Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models |
| Q57657579 | Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson’s and Gaucher diseases |
| Q47612330 | Convergent pathways in Parkinson's disease |
| Q50419934 | Dermal fibroblasts from patients with Parkinson's disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations |
| Q52689754 | Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease |
| Q38653861 | ER stress and the unfolded protein response in neurodegeneration |
| Q57817579 | Emerging Treatment Approaches for Parkinson's Disease |
| Q64071921 | Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD |
| Q41488989 | Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages |
| Q91339083 | Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells |
| Q52583995 | Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment |
| Q56889930 | FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex |
| Q99723633 | Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease |
| Q90207453 | GBA, Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches |
| Q91421330 | GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies |
| Q94465937 | Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells |
| Q94560840 | Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease |
| Q39362339 | Glucocerebrosidase Mutations in Parkinson Disease |
| Q92977525 | Glucocerebrosidase and its relevance to Parkinson disease |
| Q58693990 | Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles |
| Q39332667 | Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. |
| Q55339738 | Import and Export of Misfolded α-Synuclein. |
| Q39254537 | Induced Pluripotent Stem Cell Modeling of Gaucher's Disease: What Have We Learned? |
| Q38695115 | Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease. |
| Q64785219 | Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease |
| Q38737027 | Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. |
| Q52324550 | Intragenic transcriptional interference regulates the human immune ligand MICA. |
| Q54107836 | LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages |
| Q89879079 | Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson's Disease |
| Q96683699 | Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation |
| Q41325226 | MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons. |
| Q89493904 | Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models |
| Q91637510 | Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells |
| Q47988278 | Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity. |
| Q47611385 | Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease |
| Q46325430 | N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease |
| Q36319286 | Parkinson disease |
| Q37189019 | Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models |
| Q59335760 | Patient-Derived Induced Pluripotent Stem Cells and Organoids for Modeling Alpha Synuclein Propagation in Parkinson's Disease |
| Q57458019 | Physiological carboxy-truncation of α-synuclein potentiates the prion-like formation of pathological inclusions |
| Q37265491 | Port-to-port delivery: Mobilization of toxic sphingolipids via extracellular vesicles |
| Q39104462 | Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds |
| Q47665674 | Prying into the Prion Hypothesis for Parkinson's Disease |
| Q93052506 | Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene |
| Q58603525 | Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease |
| Q50322422 | Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease |
| Q60921456 | Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes |
| Q39148146 | The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease |
| Q39410246 | The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance |
| Q55357756 | The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients. |
| Q51284194 | The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. |
| Q39282050 | The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease. |
| Q47646796 | The genetic architecture of mitochondrial dysfunction in Parkinson's disease |
| Q90113878 | Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms |
| Q57026122 | Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes |
| Q37507550 | Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease. |
| Q51763128 | When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies |
| Q59350006 | Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease |
| Q46579323 | iPS cells in the study of PD molecular pathogenesis |
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