Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis

scientific article published on 28 November 2015

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000441724
P932PMC publication ID4801669
P698PubMed publication ID26613585
P5875ResearchGate publication ID284880052

P50authorJan PotempaQ11718746
Joanna KozielQ90311708
Malgorzata BenedykQ92741093
Aleksandra MilewskaQ95603802
Krzysztof PyrćQ37610719
Katarzyna MareszQ60290643
P2093author name stringNicolas Delaleu
Katarzyna Gawron
Karolina Płaza
Piotr Mateusz Mydel
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Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.Q34529487
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Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexesQ35610528
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Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.Q37332549
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How important are anaerobic bacteria in aspiration pneumonia: when should they be treated and what is optimal therapyQ38080616
Gingipains from Porphyromonas gingivalis - Complex domain structures confer diverse functionsQ38182102
Oral health disparities in older adults: oral bacteria, inflammation, and aspiration pneumonia.Q38247228
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Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sitesQ39823766
Modulation of cytokine production by Porphyromonas gingivalis in a macrophage and epithelial cell co-culture modelQ40438663
Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitorsQ40516682
Necrotizing pneumonia caused by mixed infection with Actinobacillus actinomycetemcomitans and Actinomyces israelii: case report and reviewQ40661529
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicityQ40801728
Porphyromonas gingivalis: a proteinase/gene accounting auditQ40953479
Head-of-bed elevation and early outcomes of gastric reflux, aspiration and pressure ulcers: a feasibility study.Q41566206
Ventilator associated pneumonia and endotracheal tube repositioning: an underrated risk factorQ41624225
Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in miceQ42456016
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria?Q42957420
Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalisQ43559287
CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L.Q43641406
Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infectionQ44219911
Thrombocytosis as a predictor of serious bacterial infectionQ45261310
Binding of Porphyromonas gingivalis gingipains to human CD4(+) T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expressionQ45302949
Aspiration pneumonia: dental and oral risk factors in an older veteran populationQ45334314
Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesionsQ46350319
Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in cultureQ46764007
Involvement of periodontopathic anaerobes in aspiration pneumoniaQ46796488
Porphyromonas gingivalis-induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinaseQ46854879
Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalisQ46949914
Pericarditis, pneumonia and brain abscess due to a combined Actinomyces--Actinobacillus actinomycetemcomitans infectionQ48460211
Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections.Q51639247
The bacteriology of aspiration pneumoniaQ54591610
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalisQ58023171
Characterization of the pulmonary inflammatory response to an anaerobic bacterial challengeQ70010943
Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formationQ71017521
Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5Q71173540
Trypsin-like protease activity of Porphyromonas gingivalis as a potential virulence factor in a murine lesion modelQ71219976
Vascular permeability enhancing activity of Porphyromonas gingivalis protease in guinea pigsQ72738085
Purification and characterization of a potent 70-kDa thiol lysyl-proteinase (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogenQ72962167
Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalisQ73427563
Global epidemiology of periodontal diseases: an overviewQ74424375
Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalisQ74578983
Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagAQ77863752
Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement systemQ80358557
Aerosolized clindamycin is superior to aerosolized dexamethasone or clindamycin-dexamethasone combination in the treatment of severe Porphyromonas gingivalis aspiration pneumonia in an experimental murine modelQ82850191
P433issue2
P921main subjectpneumoniaQ12192
aspiration pneumoniaQ677449
Porphyromonas gingivalisQ3214147
P304page(s)185-198
P577publication date2015-11-28
P1433published inJournal of Innate ImmunityQ15817533
P1476titleGingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis
P478volume8

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cites work (P2860)
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