| P2093 | author name string | Andrew P Smith | |
| | Nancy M Lee | |
| P2860 | cites work | Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1 | Q22299419 |
| | A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane | Q24293439 |
| | A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis | Q24304337 |
| | Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b | Q24306395 |
| | Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor | Q24314945 |
| | Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels | Q24793942 |
| | Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center | Q27766420 |
| | Cytokines and acute neurodegeneration | Q28190084 |
| | Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis | Q28267385 |
| | Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria | Q28270155 |
| | Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study | Q28273924 |
| | Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury | Q28511628 |
| | Late onset of motor neurons in mice overexpressing wild-type peripherin | Q28513274 |
| | A role for ZnT-1 in regulating cellular cation influx | Q28585734 |
| | Unraveling the mechanisms involved in motor neuron degeneration in ALS | Q29619073 |
| | Microglia: a sensor for pathological events in the CNS | Q29620556 |
| | Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein | Q30425734 |
| | Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice | Q31430351 |
| | Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an example | Q33942698 |
| | Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam | Q33973850 |
| | The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model | Q34052467 |
| | Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation | Q34220144 |
| | Effect of zinc sulphate and zinc methionine on growth, plasma growth hormone concentration, growth hormone receptor and insulin-like growth factor-I gene expression in mice | Q46422505 |
| | Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis | Q46427112 |
| | Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons | Q46443469 |
| | Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro | Q46471112 |
| | Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury. | Q46505513 |
| | Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/kainate receptor | Q46527954 |
| | Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase | Q46566731 |
| | Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis | Q46612575 |
| | Interleukin-1beta up-regulates expression of neurofilament light in human neuronal cells | Q46683939 |
| | Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis | Q47319947 |
| | VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model | Q47427098 |
| | Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis | Q47621315 |
| | Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression | Q48149949 |
| | Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons | Q48220506 |
| | NMDA-dependent superoxide production and neurotoxicity | Q48234286 |
| | Immunohistochemical study on the aggregation of ubiquitin in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation | Q48250384 |
| | Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures | Q48251152 |
| | Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis | Q48349098 |
| | Altered levels and distribution of microtubule-associated proteins before disease onset in a mouse model of amyotrophic lateral sclerosis | Q48425016 |
| | Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse | Q48595546 |
| | Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo | Q49056292 |
| | Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. | Q51659718 |
| | Changes in expression of bcl-2 and bax in Syrian hamster embryo (SHE) cells exposed to ZnCl2. | Q51821844 |
| | Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. | Q52114306 |
| | Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes. | Q52510591 |
| | Seizures and neuronal damage in mice lacking vesicular zinc. | Q52538742 |
| | Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. | Q52546347 |
| | Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. | Q53338345 |
| | Changes of growth inhibitory factor after stab wounds in rat brain. | Q54606525 |
| | An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria | Q54965159 |
| | Metallothioneins Are Upregulated in Symptomatic Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor-α | Q58027932 |
| | Confounding effects of mimicking disorders in the early diagnosis of amyotrophic lateral sclerosis | Q58159134 |
| | Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis | Q58477917 |
| | Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids | Q59096422 |
| | Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. | Q43823898 |
| | Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain | Q43976769 |
| | Minocycline delays disease onset and mortality in a transgenic model of ALS. | Q44024931 |
| | Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis | Q44149270 |
| | Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis | Q44160891 |
| | Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS. | Q44296123 |
| | Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. | Q44370419 |
| | Efficient three-drug cocktail for disease induced by mutant superoxide dismutase | Q44383435 |
| | Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice | Q44547353 |
| | Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature | Q44579313 |
| | Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). | Q44586345 |
| | Oxidative Modification of Neurofilament-L by Copper-catalyzed Reaction | Q44612149 |
| | Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis | Q44726519 |
| | Early activation of antioxidant mechanisms in muscle of mutant Cu/Zn-superoxide dismutase-linked amyotrophic lateral sclerosis mice | Q44807275 |
| | Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. | Q44824312 |
| | Expression of a familial amyotrophic lateral sclerosis-associated mutant human superoxide dismutase in yeast leads to decreased mitochondrial electron transport | Q44905832 |
| | Insulin growth factor-1 protects against excitotoxicity in the rat striatum | Q45062020 |
| | ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. | Q45066353 |
| | Excess incidence of ALS in young Gulf War veterans | Q45333316 |
| | Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. | Q45877621 |
| | Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. | Q45967463 |
| | Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice | Q46193323 |
| | Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity | Q46374757 |
| | Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis | Q46386504 |
| | Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function | Q34296896 |
| | Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters. | Q34309841 |
| | Roles of the metallothionein family of proteins in the central nervous system | Q34317904 |
| | Zinc and copper in the pathogenesis of amyotrophic lateral sclerosis | Q34320348 |
| | A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis | Q34342425 |
| | A pathogenic peripherin gene mutation in a patient with amyotrophic lateral sclerosis | Q34352883 |
| | Zinc binding and redox control of p53 structure and function. | Q34367589 |
| | Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis | Q34736976 |
| | Microglia as a source and target of cytokines | Q34963658 |
| | Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. | Q35029780 |
| | Neurodegenerative diseases and oxidative stress | Q35636137 |
| | Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury. | Q35699474 |
| | Mammalian zinc transporters | Q35799862 |
| | Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase | Q36270615 |
| | Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant | Q36271032 |
| | A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice | Q36321318 |
| | Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox | Q36662645 |
| | Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey | Q36829003 |
| | The physiological role of zinc as an antioxidant | Q37923918 |
| | Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis | Q38352575 |
| | Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice. | Q39435883 |
| | Metallothionein | Q39740491 |
| | The mitochondrial permeability transition. | Q40462729 |
| | Mutant copper-zinc superoxide dismutase binds to and destabilizes human low molecular weight neurofilament mRNA. | Q40499583 |
| | The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice | Q40513595 |
| | Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy | Q40724709 |
| | Oxidative stress as a mediator of apoptosis | Q40729167 |
| | Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines | Q40811604 |
| | Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis | Q40872318 |
| | Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis | Q40975834 |
| | Novel structure of the human GDNF gene | Q41010763 |
| | Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis | Q41237348 |
| | Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion | Q41269761 |
| | Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. | Q41368778 |
| | Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons | Q41644415 |
| | Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis | Q41712822 |
| | Oxygen radicals and signaling | Q41750986 |
| | Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction | Q41895159 |
| | Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis | Q41934794 |
| | Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures | Q42277605 |
| | Aggregate formation in Cu,Zn superoxide dismutase-related proteins | Q42693610 |
| | Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis | Q42828225 |
| | Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits | Q43556693 |
| | Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform | Q43559600 |
| | Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes | Q43597135 |
| | Hydrogen peroxide damages the zinc-binding site of zinc-deficient Cu,Zn superoxide dismutase | Q43685519 |
| | Induction of vascular endothelial growth factor by nitric oxide in cultured human articular chondrocytes | Q43708386 |
| | Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. | Q43763070 |
| | Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. | Q43806613 |
| | Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels | Q43809083 |
| P433 | issue | 3 | |
| P921 | main subject | amyotrophic lateral sclerosis | Q206901 |
| P304 | page(s) | 131-143 | |
| P577 | publication date | 2007-06-01 | |
| P1433 | published in | Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders | Q15759048 |
| P1476 | title | Role of zinc in ALS. | |
| P478 | volume | 8 | |