Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

scientific article published on 28 July 2008

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1700908
P932PMC publication ID2518815
P698PubMed publication ID18662975
P5875ResearchGate publication ID23133581

P2093author name stringDavid Pellman
Susana A Godinho
Neil J Ganem
Mijung Kwon
Namrata S Chandhok
Manuel Thery
Ammar Azioune
P2860cites workN-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosisQ24302527
Genes required for mitotic spindle assembly in Drosophila S2 cellsQ24629513
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targetsQ24794040
A functional genomic analysis of cell morphology using RNA interferenceQ24794931
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screenQ28146108
Targeted cancer therapies based on the inhibition of DNA strand break repairQ28260348
Comparative study and improvement of current cell micro-patterning techniquesQ28304489
Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulationQ28610904
Experimental and theoretical study of mitotic spindle orientationQ29396188
Oncogenic pathway signatures in human cancers as a guide to targeted therapiesQ29615526
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent mannerQ30479119
Extra centrosomes and/or chromosomes prolong mitosis in human cellsQ30482377
Terminal cytokinesis events uncovered after an RNAi screenQ30495347
Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryoQ30654911
Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screenQ33290209
Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A.Q33877027
The mitotic spindle: a self-made machineQ34098021
Endostatin regulates endothelial cell adhesion and cytoskeletal organization.Q34121736
Managing the centrosome numbers game: from chaos to stability in cancer cell divisionQ34123299
Centrosome aberrations: cause or consequence of cancer progression?Q34157650
Re-evaluating centrosome functionQ34354353
Epithelial cell polarity and cell junctions in DrosophilaQ34432296
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and functionQ34462214
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migrationQ34543645
INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization.Q34544252
Therapeutic potential of phosphoinositide 3-kinase inhibitors.Q35096803
The good, the bad and the ugly: the practical consequences of centrosome amplificationQ35705371
Altered centrosome structure is associated with abnormal mitoses in human breast tumorsQ35787940
Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarityQ35974979
Mitosis in a cell with multiple centriolesQ36206472
Myosin-X: a molecular motor at the cell's fingertipsQ36248392
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindleQ36326080
PAR proteins and the cytoskeleton: a marriage of equalsQ36346692
The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesisQ36366039
Cell shape and cell divisionQ36625784
Tetraploidy, aneuploidy and cancerQ36745868
Oncogenes and tumour suppressors take on centrosomesQ37001380
Centrosome amplification can initiate tumorigenesis in flies.Q37123357
Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.Q37554723
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cellsQ39450124
Quantitative morphological signatures define local signaling networks regulating cell morphology.Q40115889
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteinsQ40358374
Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instabilityQ40427115
Spindle multipolarity is prevented by centrosomal clustering.Q40473893
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugsQ40740736
DR-nm23 expression affects neuroblastoma cell differentiation, integrin expression, and adhesion characteristicsQ40790917
The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry.Q41129904
Actin based motility on retraction fibers in mitotic PtK2 cellsQ41645399
Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cellsQ41674319
A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control.Q42503128
Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell divisionQ42512850
Identification of microtubule binding sites in the Ncd tail domainQ44856733
Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesionQ47070048
Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes.Q47695895
Microtubules suppress actomyosin-based cortical flow in Xenopus oocytes.Q48953686
The extracellular matrix guides the orientation of the cell division axis.Q53656268
Genome-wide genetic analysis of polyploidy in yeastQ59071307
In situ analysis of normal and abnormal patterns of the mitotic apparatus in cultured rat-kangaroo cellsQ70128566
Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomasQ73154777
Amplified centrosomes in breast cancer: a potential indicator of tumor aggressivenessQ78714692
P433issue16
P304page(s)2189-2203
P577publication date2008-07-28
P1433published inGenes & DevelopmentQ1524533
P1476titleMechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
P478volume22

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Q31015478Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer
Q21710719Tripolar mitosis in human cells and embryos: Occurrence, pathophysiology and medical implications
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