The functional role of the renin-angiotensin system in pregnancy and preeclampsia

scientific article published on 08 August 2008

The functional role of the renin-angiotensin system in pregnancy and preeclampsia is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.PLACENTA.2008.06.011
P8608Fatcat IDrelease_xt5trxet4vhorlrr3lspzd4wx4
P932PMC publication ID2614866
P698PubMed publication ID18687466
P5875ResearchGate publication ID23156314

P2093author name stringY Xia
R A Irani
P2860cites workPlacental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?Q80316215
Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertensionQ80361560
Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lungQ80585977
Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemiaQ82705098
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesionsQ24309784
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptorQ24320710
Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.Q24537348
Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heartQ28114921
Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cellsQ28246224
Endothelin 1 and angiotensin II in preeeclampsiaQ28306251
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidneyQ30471269
Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivoQ31404999
Free radicals and antioxidants in the year 2000. A historical look to the futureQ33180577
Oxidative stress in the pathogenesis of preeclampsiaQ33796834
The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomerulosclerosisQ33838726
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.Q33853208
Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.Q33930029
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)Q33939664
Placental debris, oxidative stress and pre-eclampsiaQ34032003
Structure and function of VEGF/VEGF-receptor system involved in angiogenesisQ34246910
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expressionQ34362936
Latest advances in understanding preeclampsiaQ34425288
A study of angiotensin II pressor response throughout primigravid pregnancyQ34512573
Comparative developmental anatomy of the murine and human definitive placentae.Q34546263
Human decidua is a major source of reninQ34575720
Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysisQ34708320
Oxygen, early embryonic metabolism and free radical-mediated embryopathiesQ35081401
Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signalingQ35681804
AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsiaQ35689550
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancyQ35699115
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndromeQ35750283
Tissue factor initiates glomerular fibrin deposition and promotes major histocompatibility complex class II expression in crescentic glomerulonephritisQ35763556
Plasminogen activator inhibitor 1, fibrin, and the vascular response to injuryQ35840308
Hypoxia and sFlt-1 in preeclampsia: the "chicken-and-egg" questionQ35920602
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic miceQ36311525
Genetic progress towards the molecular basis of autoimmunity.Q36368037
Inflammation and pre-eclampsiaQ36530771
The immune system and happiness.Q36617511
Inflammatory response in preeclampsiaQ36833207
Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsiaQ37250421
Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxantsQ37377636
Control of vascular responsiveness during human pregnancyQ40122647
Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsiaQ40530224
The uteroplacental renin-angiotensin system: a reviewQ40652280
Angiotensin II inhibits human trophoblast invasion through AT1 receptor activationQ40735093
Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors.Q40867054
Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for "placental hyperoxia" in intrauterine growth restrictionQ40968880
Preeclampsia: an endothelial cell disorderQ41281924
Sodium excretion in normal and hypertensive pregnancy: a prospective studyQ41976105
Lymphocyte intracellular free calcium concentration is increased in preeclampsiaQ42472176
Effect of angiotensin II synthesis blockade on the hypertensive response to chronic reductions in uterine perfusion pressure in pregnant rats.Q43744800
Production of human mast cell chymase in human myometrium and placenta in cases of normal pregnancy and preeclampsiaQ43891523
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cellsQ44320558
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidaseQ44385661
Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damageQ44550393
Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activationQ45069619
Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic womenQ46136176
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretionQ46344658
Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsivenessQ46841539
Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusionQ46877931
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
Agonistic AT1 receptor autoantibodies and monocyte stimulation in hypertensive patients*1Q47447775
Endothelial dysfunction in preeclampsiaQ47879591
The human placental renin-angiotensin systemQ48430627
Vascular endothelial growth factor and placental growth factor release in cultured trophoblast cells under different oxygen tensions.Q51676467
Characterization of a new selective antagonist for angiotensin-(1-7), D-pro7-angiotensin-(1-7).Q51839155
Molecular evidence of placental hypoxia in preeclampsia.Q51975690
Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia.Q52940276
Physiological and pharmacological implications of AT1 versus AT2 receptors.Q54125354
Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia.Q54601823
Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in PreeclampsiaQ56981959
Production of Renin by in vitro Cultures of Human Chorion and Uterine MuscleQ59058046
Morphometric analysis of pre-eclampsia in women biopsied in pregnancy and post-partumQ67982464
Renin-aldosterone relationships in pregnancy-induced hypertensionQ68044331
A renin-like substance in the human placentaQ68564317
Immunofluorescent Studies in Renal Biopsies in Pre-eclampsiaQ69331622
Erythrocyte cation metabolism in preeclampsiaQ69354420
Changes in active and inactive renin throughout pregnancyQ70219673
Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDRQ71530460
Prostaglandins stimulate renin secretion and renin mRNA in mouse renal juxtaglomerular cellsQ71645969
Hypertension induced in pregnant mice by placental renin and maternal angiotensinogenQ71695937
Calcium metabolism in pre-eclampsiaQ73225217
Reproductive tissue renin gene expression in preeclampsiaQ73300232
Recent chymase inhibitors and their effects in in vivo modelsQ73510604
Effect of a novel vasoconstrictor endothelin-1 (1-31) on human umbilical arteryQ73642545
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
Expression of inflammatory cytokines in placentas from women with preeclampsiaQ73992120
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertensionQ74126541
Definitive molecular evidence of renin-angiotensin system in human uterine decidual cellsQ74188076
Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsiaQ74195115
An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardationQ75197234
Induction of urokinase receptor expression in nephrotoxic nephritisQ77149613
Pregnancy-induced changes in renin gene expression in miceQ77372149
Human spiral artery renin-angiotensin systemQ77418886
Angiotensin-(1-7) can interact with the rat proximal tubule AT(4) receptor systemQ78009526
Angiotensin-(1-7) in normal and preeclamptic pregnancyQ78568866
Regional flow-pressure relationship in response to angiotensin in the intact dog and sheepQ78778708
Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequencesQ79260245
Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activationQ79760387
P433issue9
P921main subjectpre-eclampsiaQ61335
P304page(s)763-771
P577publication date2008-08-08
P1433published inPlacentaQ7200288
P1476titleThe functional role of the renin-angiotensin system in pregnancy and preeclampsia
P478volume29

Reverse relations

cites work (P2860)
Q58086125(Pro)Renin Receptor Contributes to Pregnancy-Induced Sodium-Water Retention in Rats via Activation of Intrarenal RAAS and α-ENaC
Q49842182A novel rodent model of pregnancy complications associated with genetically determined angiotensin converting enzyme (ACE) activity
Q36821881A review on angiogenesis and its assays
Q38652773Adrenal responses of large whales: Integrating fecal aldosterone as a complementary biomarker to glucocorticoids
Q51007388Androgen levels are associated with blood pressure in pregnant women after term.
Q38065919Angiotensin II type I receptor A1166C polymorphism increases the risk of pregnancy hypertensive disorders: Evidence from a meta-analysis
Q64111458Angiotensin II type i receptor agonistic autoantibodies induces apoptosis of cardiomyocytes by downregulating miR21 in preeclampsia: a mechanism study
Q52874355Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction.
Q42491285Arteriolar reactivity in lymphocyte-deficient mice
Q58095884Association between intraoperative phenylephrine administration and umbilical artery pH in women with hypertensive disorders of pregnancy: a retrospective cohort study
Q90284671Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study
Q35131064Association of angiotensin-converting enzyme intron 16 insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms with preeclampsia in South East of Iran
Q53059887Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss.
Q29147510Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion
Q26828906Association of maternal AGTR1 polymorphisms and preeclampsia: a systematic review and meta-analysis
Q36295552Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis
Q41633601Associations of Angiotensin-Converting Enzyme Insertion/Deletion, Angiotensin II Receptor A1166C, and Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphisms With Pregnancy Hypertensive Disorders: A Meta-Analysis
Q34040357Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia
Q38542456Cardiac Physiology of Pregnancy
Q47546219Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians
Q38389172Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects
Q37801273Could uric acid have a pathogenic role in pre-eclampsia?
Q88711642Decompensated Heart Failure in Pregnancy
Q64970125Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD.
Q37996960Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery
Q54243943Eccrine Poroma with Rapid Growth during Pregnancy: A Case Report and Review of the Literature.
Q92190610Effect of Vitamin D supplementation during pregnancy on maternal and perinatal outcomes
Q33847163Effective prediction of preeclampsia by measuring serum angiotensin II, urinary angiotensinogen and urinary transforming growth factor β1.
Q44455143Effects of caesarean section on serum levels of NT-proBNP.
Q35040354Endothelium-dependent relaxation and angiotensin II sensitivity in experimental preeclampsia
Q36611683Expression of the renin-angiotensin system in a human placental cell line
Q21261491Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
Q47280931Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the proform of eosinophil major basic protein.
Q53760495Genophenotypic analysis of angiotensinogen gene M235T polymorphism and preeclampsia.
Q89854036Heart rate variability and hematological parameters in pregnant women
Q56985613Hemodynamic and neurohumoral profile in patients with different types of hypertension in pregnancy
Q47695443Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia
Q37850374Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia
Q35962053Inhibitory Effect of the Punica granatum Fruit Extract on Angiotensin-II Type I Receptor and Thromboxane B2 in Endothelial Cells Induced by Plasma from Preeclamptic Patients
Q92962644Is urinary excretion of plasminogen associated with development of pre-eclampsia? An observational, explorative case-control study
Q37959563Linking preeclampsia and cardiovascular disease later in life
Q38543831Linking the old and new -- do angiotensin II type 1 receptor antibodies provide the missing link in the pathophysiology of preeclampsia?
Q57127734Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay
Q64108020Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications
Q35930861Molecular regulation of human placental growth factor (PlGF) gene expression in placental villi and trophoblast cells is mediated via the protein kinase a pathway
Q35820851Nutrient availability, the microbiome, and intestinal transport during pregnancy.
Q40356250Onset and Regression of Pregnancy-Induced Cardiac Alterations in Gestationally Hypertensive Mice: The Role of the Natriuretic Peptide System
Q38067474Physiology of the female reproductive axis
Q36907975Placental Vacuolar ATPase Function Is a Key Link between Multiple Causes of Preeclampsia
Q56019568Pre-eclampsia
Q43699926Preeclampsia: effect on newborn blood pressure in the 3 days following preterm birth: a cohort study
Q37832764Preeclamptic nephropathy
Q88960880Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats
Q91607245Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs
Q36537709RAS in Pregnancy and Preeclampsia and Eclampsia
Q35363716Regulation of soluble fms-like tyrosine kinase-1 production in response to placental ischemia/hypoxia: role of angiotensin II.
Q88493279Regulators of G protein signaling in cardiovascular function during pregnancy
Q54487483Renal tubular acidosis type 4 in pregnancy.
Q38649391Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases
Q37010375Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran
Q35574735Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.
Q37502586Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators
Q33895023The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
Q39196073The Impact of Pregnancy on Taste Function
Q54391063The associations between maternal and fetal angiotensinogen M235T polymorphism and pregnancy-induced hypertension in Chinese women.
Q33591058The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia
Q50750428The expression of renin-angiotensin-aldosterone axis components in infantile hemangioma tissue and the impact of propranolol treatment.
Q46238341The pharmacology of preventing Preeclampsia
Q35939313The rat placental renin-angiotensin system - a gestational gene expression study.
Q37041658The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia
Q35767073The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua.
Q33909763The role of vitamin D in pre-eclampsia: a systematic review
Q38193086Tissue Renin-Angiotensin systems: a unifying hypothesis of metabolic disease
Q37605081Trimester Pattern of Change and Reference Ranges of Hematological Profile Among Sudanese Women with Normal Pregnancy
Q38502483Urinary proteomics analysis for renal injury in hypertensive disorders of pregnancy with iTRAQ labeling and LC-MS/MS.

Search more.