ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

scientific article published on 27 April 2016

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACSCHEMBIO.6B00291
P932PMC publication ID4947017
P698PubMed publication ID27119457

P50authorAnthony B PinkertonQ56491238
Marc CaronQ64858849
P2093author name stringWilliam C Wetsel
Michael P Hedrick
Paul Hershberger
Satyamaheshwar Peddibhotla
Thomas D Y Chung
Ramona M Rodriguiz
James B Thomas
Yushi Bai
Glen R Hanson
Larry S Barak
Sean Peterson
Nikhil M Urs
Patrick R Maloney
Tama Evron
P2860cites workThe 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptorQ22003873
Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptorQ24314254
Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brainQ24320397
A rapid and affordable screening platform for membrane protein trafficking.Q27305088
Structural Basis for Allosteric Regulation of GPCRs by Sodium IonsQ27670746
Neurotensin and neurotensin receptorsQ28138527
Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*Q28208920
Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.Q40473940
Novel predictions from radiation target analysisQ40767419
Modeling of bias for the analysis of receptor signaling in biochemical systemsQ41098045
Knockout mice and dirty drugs. Drug addictionQ41110811
The complex regulation of receptor-coupled G-proteinsQ41650513
Structure and functional expression of the cloned rat neurotensin receptorQ41733457
In vivo neurochemical and behavioural effects of intracerebrally administered neurotensin and D-Trp11-neurotensin on mesolimbic and nigrostriatal dopaminergic function in the rat.Q41917716
Half a million Americans use methamphetamine every weekQ42953279
Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous systemQ44441072
Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemiaQ44659047
Differential response of neurotensin to methamphetamine self-administrationQ46258484
Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonistQ46510974
How a G protein binds a membraneQ47406110
Tissue distribution and cellular localization of the levocabastine-sensitive neurotensin receptor mRNA in adult rat brainQ47798016
Mechanism of modulation of [3H]raclopride binding to dopaminergic receptors in rat striatal membranes by sodium ionsQ48702674
Localization of neuropeptide receptor mRNA in rat brain: Initial observations using probes for neurotensin and substance P receptorsQ48857796
Effects of neurotensin on regional brain concentrations of dopamine, serotonin and their main metabolitesQ49092167
Neurotransmitter regulation of dopamine neurons in the ventral tegmental areaQ72215317
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric bindingQ81468834
The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine HypothalamiQ28245181
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activationQ28252768
Molecular cloning of a levocabastine-sensitive neurotensin binding siteQ28280443
Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway ratsQ30397210
The role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotionQ30455967
Diverse roles of neurotensin agonists in the central nervous systemQ30456105
Contrasting trajectories of heroin, cocaine, and methamphetamine use.Q33651986
Teaching old receptors new tricks: biasing seven-transmembrane receptorsQ33985759
Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptorsQ34133265
Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteinsQ34166081
The role of hormone receptors and GTP-regulatory proteins in membrane transductionQ34245912
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?Q34275762
Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.Q34409107
G Protein and β-arrestin signaling bias at the ghrelin receptorQ34580340
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?Q34581080
Effect of methamphetamine self-administration on neurotensin systems of the basal gangliaQ34702359
Neurotensin agonists: possible drugs for treatment of psychostimulant abuseQ35152140
β-Arrestin-mediated receptor trafficking and signal transductionQ35175384
Distribution of neurotensin receptors in mammalian brain. What it is telling us about its interactions with other neurotransmitter systemsQ35273394
Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interactionQ35879672
Crystal packing analysis of Rhodopsin crystalsQ35944832
Fluoromodule-based reporter/probes designed for in vivo fluorescence imaging.Q36165610
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptorsQ36433000
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.Q36573169
Response of neurotensin basal ganglia systems during extinction of methamphetamine self-administration in ratQ37027017
GPCR monomers and oligomers: it takes all kindsQ37058647
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersQ37360436
Biased agonism as a mechanism for differential signaling by chemokine receptors.Q37368610
The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit toleranceQ37370136
Imidazole-derived agonists for the neurotensin 1 receptor.Q37502653
Allostery and the Monod-Wyman-Changeux model after 50 yearsQ37973759
Structural determinants of arrestin functionsQ38114211
Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptorsQ38869715
Distribution of neurotensin and its receptor in the central nervous systemQ40134265
P433issue7
P921main subjectbiasQ742736
P304page(s)1880-1890
P577publication date2016-05-05
P1433published inACS Chemical BiologyQ165583
P1476titleML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse
P478volume11

Reverse relations

cites work (P2860)
Q91496967A complex structure of arrestin-2 bound to a G protein-coupled receptor
Q47231111Biased signalling: from simple switches to allosteric microprocessors
Q39193257G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms
Q59138260Ghrelin Receptor Antagonism of Methamphetamine-Induced Conditioned Place Preference and Intravenous Self-Administration in Rats
Q47366066Orphan neuropeptides and receptors: Novel therapeutic targets
Q92692971Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Search more.