Robust suppression of env-SHIV viremia in Macaca nemestrina by 3-drug ART is independent of timing of initiation during chronic infection

scientific article published on October 2013

Robust suppression of env-SHIV viremia in Macaca nemestrina by 3-drug ART is independent of timing of initiation during chronic infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JMP.12060
P932PMC publication ID3772551
P698PubMed publication ID24025078

P50authorMartin PrlicQ52709414
Nicholas J MauriceQ56792650
Keith R. JeromeQ57904630
Hans-Peter KiemQ88408730
Patrick YounanQ114407261
Ann E WoolfreyQ114425570
P2093author name stringShiu-Lok Hu
Christopher W Peterson
Hannah W Miller
Patricia S Polacino
P2860cites workDifferences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; a pilot studyQ24802232
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protectionQ27332360
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS modelQ27344720
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeysQ30372757
Animal models for HIV/AIDS researchQ30423656
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapyQ30494064
Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env.Q33372270
Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selectionQ33514823
Protection of macaques against intrarectal infection by a combination immunization regimen with recombinant simian immunodeficiency virus SIVmne gp160 vaccinesQ33644522
Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.Q33968014
Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencingQ34200095
Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusionQ34203175
Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation.Q34243486
Characterisation of simian immunodeficiency virus-infected cells in pigtail macaquesQ45358306
Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5.Q45378061
Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challengeQ45401399
The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapyQ45434391
Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrinaQ45739669
Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines.Q51984455
Down-regulation of macaque gammadelta + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14Q73208165
Protection of macaques against simian AIDS by immunization with a recombinant vaccinia virus expressing the envelope glycoproteins of simian type D retrovirusQ34304734
Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapyQ34485122
A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cellsQ34625160
Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapyQ34857454
IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.Q35197395
Differential effects of HOXB4 and NUP98-HOXA10hd on hematopoietic repopulating cells in a nonhuman primate model.Q35612581
Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaquesQ35665789
Vpx is critical for SIVmne infection of pigtail macaquesQ35965316
Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3)Q36108441
Novel TRIM5 isoforms expressed by Macaca nemestrinaQ36315442
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapyQ36315555
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.Q36389032
Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptaseQ36397557
Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responsesQ36424574
Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells.Q36426601
TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularisQ36491100
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.Q36580442
Effect of early anti-retroviral therapy on the pathogenic changes in mucosal tissues of SIV infected rhesus macaques.Q36604359
Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaquesQ36608554
Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaquesQ36759774
Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapyQ36854142
Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection.Q37003523
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.Q37273086
Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virusQ37287933
Macaca mulatta, fascicularis and nemestrina in AIDS vaccine development.Q37316026
Coreceptor use in nonhuman primate models of HIV infectionQ37834099
Very late initiation of HAART impairs treatment response at 48 and 96 weeks: results from a meta-analysis of randomized clinical trials.Q37962819
Animal models of antiretroviral prophylaxis for HIV preventionQ38042299
The role of the alternative coreceptor GPR15 in SIV tropism for human cellsQ39300702
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell linesQ39683818
Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival.Q39877649
Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaquesQ40270173
Initiation of HAART during acute simian immunodeficiency virus infection rapidly controls virus replication in the CNS by enhancing immune activity and preserving protective immune responsesQ41130300
SIV-induced impairment of neurovascular repair: a potential role for VEGF.Q41764095
Comparison of HIV-specific CD8 T-cell responses among uninfected individuals exposed to HIV parenterally and mucosallyQ42648316
Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160.Q44455932
Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxisQ44811843
P433issue5
P921main subjectsouthern pig-tailed macaqueQ618026
P304page(s)237-246
P577publication date2013-10-01
P1433published inJournal of Medical PrimatologyQ15755599
P1476titleRobust suppression of env-SHIV viremia in Macaca nemestrina by 3-drug ART is independent of timing of initiation during chronic infection
P478volume42

Reverse relations

cites work (P2860)
Q38839394Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia
Q52718314Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.
Q58561116Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
Q91652439Experimental Treatment of SIV-Infected Macaques via Autograft of CCR5-Disrupted Hematopoietic Stem and Progenitor Cells
Q36067042Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation
Q27318042Lentivirus-mediated Gene Transfer in Hematopoietic Stem Cells Is Impaired in SHIV-infected, ART-treated Nonhuman Primates
Q47172279Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.
Q37661792Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation
Q36613666Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS
Q35432739Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques

Search more.