Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia

scientific article published on 27 February 2009

Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.01227.2008
P932PMC publication ID2685329
P698PubMed publication ID19252088
P5875ResearchGate publication ID24146625

P2093author name stringM A Sussman
C C Glembotski
N Gude
R Whittaker
R A Gottlieb
M S Glassy
P2860cites workHuman alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosisQ24306784
Expression of the murine alpha B-crystallin gene is not restricted to the lensQ24633848
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophilsQ28141837
Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomesQ28211937
Activation of Notch-mediated protective signaling in the myocardiumQ28274092
AlphaB-crystallin in lens development and muscle integrity: a gene knockout approachQ28512665
Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivoQ77306397
TOM20 and the heartbreakers: evidence for the role of mitochondrial transport proteins in cardioprotectionQ80064251
Ischemic preconditioning protects by activating prosurvival kinases at reperfusionQ80546877
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cellsQ28568572
Alpha B-crystallin suppresses pressure overload cardiac hypertrophyQ28571805
AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cellsQ28575601
Translocation of small heat shock proteins to the actin cytoskeleton upon proteasomal inhibitionQ28581535
Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusionQ31825986
A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesisQ33314909
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signalingQ33836897
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activationQ33938470
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivoQ34293330
Alpha B-crystallin in cardiac tissue. Association with actin and desmin filamentsQ34466918
The role of p38 mitogen-activated protein kinase in myocardial ischemia/reperfusion injury; relationship to ischemic preconditioning.Q34732313
The first minutes of reperfusion: a window of opportunity for cardioprotectionQ35666872
STRESS signaling pathways that modulate cardiac myocyte apoptosisQ35995681
Small heat shock proteins: a new classification scheme in mammalsQ36055893
Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspectsQ36497007
Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytesQ36620605
CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging miceQ36933115
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivoQ36952671
Making the heart resistant to infarction: how can we further decrease infarct size?Q36991774
Targeting p38-MAPK in the ischaemic heart: kill or cure?Q37090831
Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heartQ37353324
Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosisQ39937560
Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genesQ40693937
The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activationQ40715426
Mimicking phosphorylation of alphaB-crystallin affects its chaperone activityQ41084011
p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model systemQ41732350
alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress responseQ41736665
The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturationQ43556597
MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent mannerQ44160668
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosisQ44306740
Roles for αB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse modelQ44639137
Association of the chaperone alphaB-crystallin with titin in heart muscle.Q44693938
c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neuronsQ46109478
Role of F-actin organization in p38 MAP kinase-mediated apoptosis and necrosis in neonatal rat cardiomyocytes subjected to simulated ischemia and reoxygenationQ46616117
Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusionQ46907132
Ischemia-induced phosphorylation and translocation of stress protein alpha B-crystallin to Z lines of myocardium.Q48014059
Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?Q52123671
Phosphorylation of alphaB-crystallin in response to various types of stress.Q52191790
CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake.Q53624149
Inhibition of myocardial apoptosis by ischaemic and beta-adrenergic preconditioning is dependent on p38 MAPK.Q53631218
The small heat shock protein alphaB-crystallin inhibits differentiation-induced caspase 3 activation and myogenic differentiationQ64377528
Cardiac alpha-crystallin. III. Involvement during heart ischemiaQ68665889
Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell deathQ73531785
P433issue5
P921main subjectmitochondrionQ39572
phosphorylationQ242736
P304page(s)H1633-42
P577publication date2009-02-27
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleKinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia
P478volume296

Reverse relations

cites work (P2860)
Q35895549A comparison of phosphospecific affinity reagents reveals the utility of recombinant Forkhead-associated domains in recognizing phosphothreonine-containing peptides
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Q33895695Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium.
Q37411132Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
Q28592852Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes
Q33478305Mitochondrial proteomics in experimental autoimmune uveitis oxidative stress
Q36319594Novel roles for α-crystallins in retinal function and disease
Q53113761O-GlcNAcylation of αB-crystallin regulates its stress-induced translocation and cytoprotection.
Q46719966Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis
Q26785450Phosphorylation of αB-crystallin: Role in stress, aging and patho-physiological conditions
Q83347233Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy
Q35871248Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity
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Q36143828Small heat shock proteins in redox metabolism: implications for cardiovascular diseases
Q36336732Study of αB-crystallin expression in Gerbil BCAO model of transient global cerebral ischemia
Q64120214The BAG3-dependent and -independent roles of cardiac small heat shock proteins
Q42587755The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity
Q92139766The small heat shock proteins, HSPB1 and HSPB5, interact differently with lipid membranes
Q38404383Therapeutic potential of α-crystallin
Q28384995αB-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cells

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