Super DksAs: substitutions in DksA enhancing its effects on transcription initiation

scientific article published on 07 May 2009

Super DksAs: substitutions in DksA enhancing its effects on transcription initiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2009.126
P932PMC publication ID2699356
P698PubMed publication ID19424178
P5875ResearchGate publication ID24410133

P2093author name stringChristophe Herman
Jennifer A Halliday
Jeong-Hyun Lee
Richard L Gourse
Wilma Ross
Christopher W Lennon
Matthew D Blankschien
Elicia D Grace
P2860cites workCoSMoS: Conserved Sequence Motif Search in the proteomeQ25255630
Crystal Structure of Escherichia coli Rnk, a New RNA Polymerase-Interacting ProteinQ27651883
Crystal structure of the GreA transcript cleavage factor from Escherichia coliQ27730368
The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coliQ28277451
(p)ppGpp: still magical?Q28278758
TraR, a homolog of a RNAP secondary channel interactor, modulates transcriptionQ28474472
Mechanism of regulation of transcription initiation by ppGpp. I. Effects of ppGpp on transcription initiation in vivo and in vitroQ31852675
Mechanism of regulation of transcription initiation by ppGpp. II. Models for positive control based on properties of RNAP mutants and competition for RNAP.Q31852702
DksA potentiates direct activation of amino acid promoters by ppGppQ33841173
Structural basis for transcription regulation by alarmone ppGpp.Q34316432
Intrinsic transcript cleavage activity of RNA polymeraseQ34348611
ppGpp: a global regulator in Escherichia coli.Q34415352
Backtracking by single RNA polymerase molecules observed at near-base-pair resolutionQ34698969
Effects of DksA, GreA, and GreB on transcription initiation: insights into the mechanisms of factors that bind in the secondary channel of RNA polymeraseQ35729042
The rpoB mutants destabilizing initiation complexes at stringently controlled promoters behave like "stringent" RNA polymerases in Escherichia coliQ35974407
Bacterial transcription elongation factors: new insights into molecular mechanism of actionQ36048717
New horizons for (p)ppGpp in bacterial and plant physiology.Q36339121
Transcription profiling of the stringent response in Escherichia coliQ36421860
Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulationQ36565042
Advances in bacterial promoter recognition and its control by factors that do not bind DNA.Q36980036
Allosteric control of Escherichia coli rRNA promoter complexes by DksA.Q37111105
Regulation of the fimB promoter: a case of differential regulation by ppGpp and DksA in vivo.Q38293420
Modulation of DNA repair by mutations flanking the DNA channel through RNA polymeraseQ39693158
Induction of expression of hfq by DksA is essential for Shigella flexneri virulenceQ40223748
Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymeraseQ41629112
Identical, independent, and opposing roles of ppGpp and DksA in Escherichia coliQ41790469
Mapping of catalytic residues in the RNA polymerase active centerQ42631731
Procedure for the rapid, large-scale purification of Escherichia coli DNA-dependent RNA polymerase involving polymin P precipitation and DNA-cellulose chromatographyQ43853213
Control of rRNA expression by small molecules is dynamic and nonredundantQ44530417
Isolation of RNA polymerase suppressors of a (p)ppGpp deficiencyQ44720107
ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor sigmaE in Escherichia coli by both direct and indirect mechanisms.Q46845845
RNA polymerase mutants that destabilize RNA polymerase-promoter complexes alter NTP-sensing by rrn P1 promotersQ47923669
Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coliQ48314806
ppGpp with DksA controls gene expression in the locus of enterocyte effacement (LEE) pathogenicity island of enterohaemorrhagic Escherichia coli through activation of two virulence regulatory genes.Q53613130
Properties of RNA polymerase bypass mutants: implications for the role of ppGpp and its co-factor DksA in controlling transcription dependent on sigma54.Q54442568
The guanosine tetraphosphate (ppGpp) alarmone, DksA and promoter affinity for RNA polymerase in regulation of sigma-dependent transcription.Q54466501
Antagonistic regulation of Escherichia coli ribosomal RNA rrnB P1 promoter activity by GreA and DksA.Q54467519
Regulation through the Secondary Channel—Structural Framework for ppGpp-DksA Synergism during TranscriptionQ57895265
Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutationsQ70119536
Multiple RNA polymerase conformations and GreA: control of the fidelity of transcriptionQ72593156
Promoter recognition and discrimination by EsigmaS RNA polymeraseQ77333834
DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTPQ80417641
P433issue12
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)1720-1731
P577publication date2009-05-07
P1433published inThe EMBO JournalQ1278554
P1476titleSuper DksAs: substitutions in DksA enhancing its effects on transcription initiation
P478volume28

Reverse relations

cites work (P2860)
Q39254510A Rhodobacter sphaeroides protein mechanistically similar to Escherichia coli DksA regulates photosynthetic growth
Q42859195A hyper-mutant of the unusual sigma70-Pr promoter bypasses synergistic ppGpp/DksA co-stimulation
Q33924072An insertion in the catalytic trigger loop gates the secondary channel of RNA polymerase
Q36631410Bacterial Transcription as a Target for Antibacterial Drug Development.
Q43149169Bacterial global regulators DksA/ppGpp increase fidelity of transcription
Q42573633Characterization of a novel RNA polymerase mutant that alters DksA activity
Q36464979Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation
Q46276966DksA and ppGpp Regulate the σS Stress Response by Activating Promoters for the Small RNA DsrA and the Anti-Adapter Protein IraP.
Q36337732DksA involvement in transcription fidelity buffers stochastic epigenetic change
Q36394340DksA regulates RNA polymerase in Escherichia coli through a network of interactions in the secondary channel that includes Sequence Insertion 1
Q37629025Elongation by RNA polymerase: a race through roadblocks
Q37333305Escherichia coli DksA binds to Free RNA polymerase with higher affinity than to RNA polymerase in an open complex
Q36340118Growth rate regulation in Escherichia coli
Q47442944Interplay between σ region 3.2 and secondary channel factors during promoter escape by bacterial RNA polymerase
Q100395110Mutational analysis of Escherichia coli GreA protein reveals new functional activity independent of antipause and lethal when overexpressed
Q33858878Recombination phenotypes of Escherichia coli greA mutants
Q35783077Role of the coiled-coil tip of Escherichia coli DksA in promoter control
Q34148377Signal sensory systems that impact σ⁵⁴ -dependent transcription.
Q37473055The dual role of DksA protein in the regulation of Escherichia coli pArgX promoter.
Q42550654The transcription factor DksA prevents conflicts between DNA replication and transcription machinery
Q38708051TraR directly regulates transcription initiation by mimicking the combined effects of the global regulators DksA and ppGpp
Q42637913Transcription from bacteriophage lambda pR promoter is regulated independently and antagonistically by DksA and ppGpp
Q35906066Transcription initiation factor DksA has diverse effects on RNA chain elongation
Q64915092Transcriptional Responses to ppGpp and DksA.
Q35584326pH dependence of the stress regulator DksA
Q42578226ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response

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