Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.

scientific article published on 22 August 2016

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20151938
P932PMC publication ID5030800
P698PubMed publication ID27551156

P50authorRksubbarao MalireddiQ82557171
Cliff GuyQ87686254
Geoffrey NealeQ87686255
Xiaopeng QiQ88180909
Si Ming ManQ42648826
Prajwal GurungQ56798753
P2093author name stringChristopher Lupfer
Rajendra Karki
Thirumala-Devi Kanneganti
Mohamed Lamkanfi
P2860cites workCathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptorsQ80026097
A gene network regulating lysosomal biogenesis and functionQ24339409
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksQ24612235
Converging roles of caspases in inflammasome activation, cell death and innate immunityQ26776532
A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their ExpulsionQ27322719
Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primatesQ27323387
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesQ29614469
TFEB links autophagy to lysosomal biogenesisQ29614835
The NALP3 inflammasome is involved in the innate immune response to amyloid-betaQ29615595
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsQ29615704
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?Q29619524
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
The AIM2 inflammasome is critical for innate immunity to Francisella tularensisQ29622833
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulinQ30482362
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBQ30508509
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.Q33813206
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.Q34006614
Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agentQ34087529
Signals from the lysosome: a control centre for cellular clearance and energy metabolismQ34340780
Lysosomal physiologyQ34462083
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavageQ34463859
Distinct roles for cysteine cathepsin genes in multistage tumorigenesisQ34471105
Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growthQ34961788
Life on the inside: the intracellular lifestyle of cytosolic bacteriaQ34975988
Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replicationQ35080775
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infectionQ35177551
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cellsQ35409371
Regulation of inflammasome activationQ35456425
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infectionQ35528340
Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.Q35805338
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosisQ35868248
Phosphoinositide isoforms determine compartment-specific ion channel activityQ36094211
Type I interferon signaling is required for activation of the inflammasome during Francisella infectionQ36229342
Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathwayQ36235471
Pathogen-endoplasmic-reticulum interactions: in through the out doorQ36402241
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunityQ36592682
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.Q36709792
Lysosomes: fusion and functionQ36885390
Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112.Q36974385
Francisella tularensis phagosomal escape does not require acidification of the phagosomeQ37191367
Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.Q37297985
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolismQ37378754
A Francisella tularensis pathogenicity island required for intramacrophage growthQ37513704
Bacterial manipulation of innate immunity to promote infection.Q37675898
Immunity to FrancisellaQ37891779
Lysosomal cell death at a glance.Q38110528
Bacteria-autophagy interplay: a battle for survivalQ38175276
Secondary biochemical and morphological consequences in lysosomal storage diseasesQ38238429
Mucolipidosis type IV protein TRPML1-dependent lysosome formationQ38930529
Francisella tularensis regulates autophagy-related host cell signaling pathwaysQ40025482
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's diseaseQ40230652
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathwaysQ40883748
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium releaseQ41822869
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.Q41831125
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severityQ44104053
The contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophagesQ46401888
Stat3 controls lysosomal-mediated cell death in vivoQ48530601
Modulation of biogenesis of the Francisella tularensis subsp. novicida-containing phagosome in quiescent human macrophages and its maturation into a phagolysosome upon activation by IFN-gamma.Q50763789
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.Q51547401
Normal neutrophil function in cathepsin G-deficient miceQ73254135
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsisQ74539695
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectFrancisella novicidaQ16982112
P304page(s)2081-2097
P577publication date2016-08-22
P1433published inJournal of Experimental MedicineQ3186912
P1476titleCathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
P478volume213

Reverse relations

cites work (P2860)
Q64086773AMPK-Targeted Effector Networks in Mycobacterial Infection
Q59330164AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia
Q90290679Cysteine Cathepsins in Tumor-Associated Immune Cells
Q64991702Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Q39385660Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents
Q64951483HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Q64374734HIF1A and NFAT5 coordinate Na-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting
Q49571710Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.
Q90048040Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions
Q98568657RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
Q94541646TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis
Q90411079TRPML Cation Channels in Inflammation and Immunity
Q42636973Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo
Q49909451Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

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