Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability

scientific article published on 19 April 2009

Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1047498173
P356DOI10.1038/NCB1872
P932PMC publication ID2746449
P698PubMed publication ID19377467
P5875ResearchGate publication ID24308404

P2093author name stringZissimos Mourelatos
Yohei Kirino
Thomas A Jongens
Isidore Rigoutsos
Peter S Klein
Namwoo Kim
Eugene Khandros
Mariàngels de Planell-Saguer
Stephanie Chiorean
P2860cites workTwo distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteinsQ24337867
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteinsQ24548244
A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewalQ24595550
Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogasterQ24683818
SMN tudor domain structure and its interaction with the Sm proteinsQ27629094
The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodiesQ28140527
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cellsQ28142394
The small RNA profile during Drosophila melanogaster developmentQ28201894
Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pIClnQ28211723
Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testesQ28255334
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in DrosophilaQ28290099
Discrete small RNA-generating loci as master regulators of transposon activity in DrosophilaQ28292093
Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in miceQ28586082
Developmentally regulated piRNA clusters implicate MILI in transposon controlQ28593121
A distinct small RNA pathway silences selfish genetic elements in the germlineQ29614717
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune diseaseQ29616423
Arginine methylation an emerging regulator of protein functionQ29617311
Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.Q34003175
Mighty Piwis defend the germline against genome intrudersQ34003431
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.Q34003437
Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germlineQ34338781
Conserved themes in small-RNA-mediated transposon controlQ34370338
Tudor domains bind symmetrical dimethylated argininesQ34426427
Xenbase: a Xenopus biology and genomics resourceQ34584638
Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco geneQ34643946
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.Q34644431
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' endsQ35855652
Sm protein methylation is dispensable for snRNP assembly in Drosophila melanogaster.Q36575678
Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potentialQ36605563
Germ versus soma decisions: lessons from flies and wormsQ36796578
piRNAs--the ancient hunters of genome invadersQ36885870
How selfish retrotransposons are silenced in Drosophila germline and somatic cellsQ37197624
A proteomic analysis of arginine-methylated protein complexesQ44611061
The role of Tudor domains in germline development and polar granule architectureQ47070085
Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila.Q47071167
Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C.Q47071373
Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase CapsuléenQ47071666
The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance.Q47072191
The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylatedQ51039169
tudor, a gene required for assembly of the germ plasm in Drosophila melanogasterQ52264942
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)652-658
P577publication date2009-04-19
P1433published inNature Cell BiologyQ1574111
P1476titleArginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
P478volume11

Reverse relations

cites work (P2860)
Q37224441A Primary Sequence Analysis of the ARGONAUTE Protein Family in Plants.
Q93253703A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
Q33614944A broadly conserved pathway generates 3'UTR-directed primary piRNAs
Q30984094A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like Argonaute in the single-cell human parasite Toxoplasma gondii
Q35210989A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing
Q35532755A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
Q37395186Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis.
Q34211342An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila
Q47687611Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway
Q39068063Analysis of sDMA modifications of PIWI proteins
Q35909969Aphids: A Model for Polyphenism and Epigenetics
Q34357395Arginine methylation as a molecular signature of the Piwi small RNA pathway
Q33572966Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization
Q35775944Arginine methylation of RNA‐binding proteins regulates cell function and differentiation
Q33707074Arginine methylation of vasa protein is conserved across phyla
Q37118195Argonaute protein as a linker to command center of physiological processes
Q38111603Argonaute proteins: functional insights and emerging roles
Q37454151Asian Citrus Psyllid RNAi Pathway - RNAi evidence
Q34370172Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis
Q28278697Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines
Q34087911Building RNA-protein granules: insight from the germline
Q35909748CPEB and miR-15/16 Co-Regulate Translation of Cyclin E1 mRNA during Xenopus Oocyte Maturation
Q34154255Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells
Q39242552Colorado potato beetle (Coleoptera) gut transcriptome analysis: expression of RNA interference-related genes.
Q92740666Comparative Proteomics Reveal Me31B's Interactome Dynamics, Expression Regulation, and Assembly Mechanism into Germ Granules during Drosophila Germline Development
Q26824060Concise Review: The Piwi‐piRNA Axis: Pivotal Beyond Transposon Silencing
Q37931616Deciphering arginine methylation: Tudor tells the tale.
Q92322365Distinct roles of Argonaute in the green alga Chlamydomonas reveal evolutionary conserved mode of miRNA-mediated gene expression
Q50300107Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway
Q64258180Dual regulation of Arabidopsis AGO2 by arginine methylation
Q34127456Elective affinities: a Tudor-Aubergine tale of germline partnership
Q90266900Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia
Q24630397Establishing, maintaining and modifying DNA methylation patterns in plants and animals
Q27024806Evolutionarily conserved protein arginine methyltransferases in non‐mammalian animal systems
Q87045773Expression of mep50 in adult and embryos of medaka fish (Oryzias latipes)
Q40459386Functional analyses of phosphorylation events in human Argonaute 2.
Q33553009Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
Q35711330Gender-Specific Hierarchy in Nuage Localization of PIWI-Interacting RNA Factors in Drosophila
Q90637050Genes Involved in Drosophila melanogaster Ovarian Function Are Highly Conserved Throughout Evolution
Q50915851Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.
Q38027154Germ granules in spermatogenesis of Drosophila: Evidences of contribution to the piRNA silencing
Q35192244Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements
Q46598761Heterogeneity of chromatoid bodies in adult pluripotent stem cells of planarian Dugesia japonica
Q34234176Heterotypic piRNA Ping-Pong Requires Qin, a Protein with Both E3 Ligase and Tudor Domains
Q33767860How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
Q39971766Identification of PIWIL1 Isoforms and Their Expression in Bovine Testes, Oocytes, and Early Embryos
Q64063762Identification of piRNAs and piRNA clusters in the testes of the Mongolian horse
Q38735703Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway
Q91744579Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1
Q55345627Longevity and transposon defense, the case of termite reproductives.
Q28511307Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile
Q28592934MVH in piRNA processing and gene silencing of retrotransposons
Q42754906Mammalian piRNAs: Biogenesis, function, and mysteries
Q36149875Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis
Q35135678Minireview: The roles of small RNA pathways in reproductive medicine
Q37371778Mitochondrial protein BmPAPI modulates the length of mature piRNAs
Q27658209Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi
Q38766370Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline
Q27015738Next generation organelles: Structure and role of germ granules in the germline
Q37069709Novel mutants of the aubergine gene
Q26774774One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing
Q34781445PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition
Q36320681PIWI Expression and Function in Cancer
Q33796234PIWI homologs mediate histone H4 mRNA localization to planarian chromatoid bodies
Q34215557PIWI proteins are dispensable for mouse somatic development and reprogramming of fibroblasts into pluripotent stem cells
Q29614712PIWI-interacting small RNAs: the vanguard of genome defence
Q36928863PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA
Q35768070PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells.
Q42702906PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers
Q98222280PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
Q36811735Phosphorylation of Ago2 and Subsequent Inactivation of let-7a RNP-Specific MicroRNAs Control Differentiation of Mammalian Sympathetic Neurons
Q34593170Piwi Proteins and piRNAs step onto the systems biology stage
Q26823327Piwi and potency: PIWI proteins in animal stem cells and regeneration
Q47072838Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila
Q37937754Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation
Q35191784Protein Arginine Methylation in Parasitic Protozoa
Q38067063Protein arginine methyltransferases and cancer
Q92024916Protein components of ribonucleoprotein granules from Drosophila germ cells oligomerize and show distinct spatial organization during germline development
Q37287579Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
Q35578422RNA granules in germ cells
Q37479408RNA interference in Trypanosoma brucei: role of the n-terminal RGG domain and the polyribosome association of argonaute
Q33836718Rapid evolution of piRNA pathway in the teleost fish: implication for an adaptation to transposon diversity
Q43030518Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment.
Q36698070Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm
Q36988764Signaling pathways that control mRNA turnover
Q38947781Silencing transposable elements in the Drosophila germline.
Q37809240Small RNA-Mediated Quiescence of Transposable Elements in Animals
Q33987211Small RNAs in the animal gonad: guarding genomes and guiding development.
Q38231993Small noncoding RNAs and male infertility
Q27675678Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins
Q27664064Structural basis for methylarginine-dependent recognition of Aubergine by Tudor
Q24615547Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain
Q52659629Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi
Q27683686Structure and domain organization of Drosophila Tudor
Q50186703Subcellular Specialization and Organelle Behavior in Germ Cells
Q37383030Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi.
Q35178299Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish.
Q28588151Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
Q38436579Testosterone alters testis function through regulation of piRNA expression in rats.
Q37738598The Conservation of the Germline Multipotency Program, from Sponges to Vertebrates: A Stepping Stone to Understanding the Somatic and Germline Origins.
Q27683520The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
Q90053669The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm
Q47374962The PIWI-Interacting RNA Molecular Pathway: Insights From Cultured Silkworm Germline Cells
Q28085672The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
Q38639551The Pole (Germ) Plasm in Insect Oocytes
Q28591627The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing
Q34410063The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster
Q63246550The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes
Q90100211The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila
Q33685563The meaning of PIWI proteins in cancer development.
Q27673500The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors
Q26776405The piRNA Pathway Guards the Germline Genome Against Transposable Elements
Q92609304The piRNA pathway in Drosophila ovarian germ and somatic cells
Q37183402The piRNA pathway: a fly's perspective on the guardian of the genome.
Q35759981The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs inDrosophila
Q28588526Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs
Q36548253Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division.
Q58067129Tudor Domain
Q39995016Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila.
Q90781371UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells
Q89891668UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis
Q37322266Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms
Q46439213Xenopus Piwi proteins interact with a broad proportion of the oocyte transcriptome.
Q48642172Xtr, a plural tudor domain‐containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis
Q46848007Zucchini-dependent piRNA processing is triggered by recruitment to the cytoplasmic processing machinery
Q33755357dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster
Q38112435piRNA pathway and the potential processing site, the nuage, in the Drosophila germline
Q47148126piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.
Q37973416piRNAs and their involvement in male germline development in mice
Q34368569piRNAs, transposon silencing, and Drosophila germline development

Search more.