Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host

scientific article published on February 2010

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/J.1600-0757.2009.00324.X
P932PMC publication ID2796596
P698PubMed publication ID20017800
P5875ResearchGate publication ID40695166

P50authorJohn D. LambrisQ6228220
Jan PotempaQ11718746
George HajishengallisQ39672238
P2093author name stringJennifer L Krauss
P2860cites workCrystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist EritoranQ24292781
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptideQ24294695
Toll-like receptor signallingQ24570126
Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense functionQ24652536
Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?Q24655246
Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophagesQ24678639
Innate immune recognitionQ27860721
Bacterial biofilms: a common cause of persistent infectionsQ27861033
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityQ28131769
Complement-induced impairment of innate immunity during sepsisQ28221448
The dark side of C5a in sepsisQ28252425
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adultsQ28289939
Anti-immunology: evasion of the host immune system by bacterial and viral pathogensQ28298920
Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC functionQ28487159
Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussisQ28511441
Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Recognition of microorganisms and activation of the immune responseQ29617903
Negative regulation of toll-like receptor-mediated immune responsesQ29619019
Complement-dependent clearance of apoptotic cells by human macrophagesQ30442812
Toll-like receptors control autophagy.Q30481722
Fluorescence in situ hybridization (FISH) for direct visualization of bacteria in periapical lesions of asymptomatic root-filled teethQ30922787
Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cellsQ31813068
STUDIES OF THE PREDOMINANT CULTIVABLE MICROBIOTA OF DENTAL PLAQUE.Q33191981
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at largeQ33342232
The simple design of complement factor H: Looks can be deceivingQ33372312
Genetic influence on bloodstream infections and sepsisQ37291989
Complement evasion by human pathogensQ33623972
Regulation of the complement membrane attack pathwayQ33697279
Oral mucosal endotoxin tolerance induction in chronic periodontitisQ33797036
Opsonization of Four Bacteroides Species: Role of the Classical Complement Pathway and ImmunoglobulinQ33900338
Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction.Q33942345
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblastsQ34004872
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalisQ34010067
A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulenceQ34115870
Taxonomy and virulence of oral spirochetesQ34129554
Complement-targeted therapeuticsQ34255011
Microbiology of periodontal disease in children and young adultsQ34308320
Periodontal microbial ecologyQ34413957
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosisQ34461296
Periodontal diseases.Q34468885
Role of Treponema denticola in periodontal diseasesQ34632698
Destructive periodontitis lesions are determined by the nature of the lymphocytic response.Q34720552
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection.Q34862986
Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cellsQ34945846
The role of the anaphylatoxins in health and diseaseQ34983578
Corruption of innate immunity by bacterial proteasesQ35003110
Microbiology of polymicrobial abscesses and implications for therapyQ35013667
Origin and function of the cellular components in gingival crevice fluidQ35092082
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogensQ35120164
Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium sppQ35453387
Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cellsQ35618751
Modulation of the innate immune response within the periodontium.Q35755283
Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal diseaseQ35783899
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivoQ35850677
Toll-like receptors in the pathogenesis of human diseaseQ35904386
Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?Q35951845
The role of complement in inflammatory diseases from behind the scenes into the spotlightQ35963146
Role of C5a in inflammatory responsesQ36072464
Spirochetes at the forefront of periodontal infectionsQ36107775
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from natureQ37320731
Functions of C5a receptorsQ37369597
Toll gates to periodontal host modulation and vaccine therapyQ37416211
The oral microbial consortium's interaction with the periodontal innate defense systemQ37478630
Bacterial adhesins in host-microbe interactions.Q37520112
Activation of the complement system generates antibacterial peptidesQ37695583
Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complementQ38481466
Microbial complexes in subgingival plaqueQ38553206
Complement activation by Propionibacterium acnes and Bacteroides melaninogenicusQ39236931
Gingival fluid and serum in periodontal diseases. I. Quantitative study of immunoglobulins, complement components, and other plasma proteinsQ39466529
Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2.Q39521511
Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2.Q39522825
Macrophage receptors for Mycobacterium tuberculosisQ39570480
Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis.Q39570767
Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4.Q39653471
Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2.Q39714403
Complement factors in gingival crevice material from healthy and inflamed gingiva in humansQ39734410
Purification and partial characterization of an elastolytic serine protease of Prevotella intermediaQ39858070
Porphyromonas gingivalis with either Tannerella forsythia or Treponema denticola induces synergistic IL-6 production by murine macrophage-like J774.1 cells.Q39892077
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.Q40014914
Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA.Q40060686
Serological properties of lipopolysaccharide from oral stains of Bacteroides melaninogenicusQ40110937
Inhibition of superoxide production in human polymorphonuclear leukocytes by oral treponemal factors.Q40157572
Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatusQ40230062
TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriaeQ40271727
MD-2 mediates the ability of tetra-acylated and penta-acylated lipopolysaccharides to antagonize Escherichia coli lipopolysaccharide at the TLR4 signaling complexQ40370317
Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2.Q40565984
Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.Q40587107
Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytesQ40600671
Role of dentilisin in Treponema denticola epithelial cell layer penetrationQ40620534
Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modificationsQ40626961
Detection of Functional Complement Components in Gingival Crevicular Fluid from Humans with Periodontal DiseaseQ40765711
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathwayQ40819427
Anaerobic bacterial infections of the lung and pleural spaceQ40822065
Gingival Fluid and Serum in Periodontal Diseases: II. Evidence for Cleavage of Complement Components C3, C3 Proactivator (Factor B) and C4 in Gingival FluidQ40839980
Complement factor D̄-like activity of Porphyromonas gingivalis W83Q41132518
Escape from immune surveillance by Capnocytophaga canimorsusQ41450628
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide responseQ41452286
IL-6 is produced by osteoblasts and induces bone resorptionQ41714818
Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath componentsQ41874304
Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production.Q41911213
Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activitiesQ42714693
Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriaeQ42913501
Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalisQ43559287
Coaggregation of Porphyromonas gingivalis and Prevotella intermediaQ43788842
Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivoQ43985683
Does the frequency of Prevotella intermedia increase during pregnancy?Q44031656
Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermediaQ44425221
Chemical structure and immunobiological activity of lipid A from Prevotella intermedia ATCC 25611 lipopolysaccharideQ44445573
C5a negatively regulates toll-like receptor 4-induced immune responsesQ44924554
Activation of complement by Treponema denticolaQ44951927
Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migrationQ45005871
Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinaseQ45288377
Microbial composition of supra- and subgingival plaque in subjects with adult periodontitisQ46193392
Coaggregation of Treponema denticola with Porphyromonas gingivalis and Fusobacterium nucleatum is mediated by the major outer sheath protein of Treponema denticolaQ46215752
Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.Q46312320
Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases.Q46620016
G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.Q46664094
Regulation by C5a of neutrophil activation during sepsisQ47672797
Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host responseQ47871178
DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues.Q47885725
Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections.Q51639247
Seeking wisdom in innate immunity.Q52553666
TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity.Q54443903
Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages.Q54476982
Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytesQ57920105
The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophilsQ57986724
Generation of C5a in the absence of C3: a new complement activation pathwayQ58523865
Nature and Composition of Dental PlaqueQ58972442
Assessment of complement cleavage in gingival fluid during experimental gingivitis in manQ69484403
Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5Q71173540
Bactericidal effect of pooled human serum on Bacteroides melaninogenicus, Bacteroides asaccharolyticus and Actinobacillus actinomycetemcomitansQ72527025
Impairment by Bacteroides Species of Opsonisation and Phagocytosis of EnterobacteriaQ72534978
Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitisQ73005601
Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytesQ73073888
Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasionQ73552827
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cellsQ74285101
Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine modelQ77745563
Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorptionQ79401044
Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteriaQ80291404
Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement systemQ80358557
The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitisQ81452304
Proteinase activity of prevotella species associated with oral purulent infectionQ83061612
A global analysis of cross-talk in a mammalian cellular signalling networkQ83339233
Polymicrobial infections, biofilms, and beyondQ83778239
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitisQ36107786
Treponema denticola activates mitogen-activated protein kinase signal pathways through Toll-like receptor 2Q36313921
Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytesQ36348349
Environmental and other modifying factors of the periodontal diseasesQ36362698
Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complementQ36384714
Protective and destructive immunity in the periodontium: Part 1--innate and humoral immunity and the periodontiumQ36404749
Th17: the third member of the effector T cell trilogyQ36528977
Generation of signals activating neutrophil functions by leukocyte integrins: LFA-1 and gp150/95, but not CR3, are able to stimulate the respiratory burst of human neutrophilsQ36531011
Molecular genetics analyses of biofilm formation in oral isolatesQ36575939
Tannerella forsythia, a periodontal pathogen entering the genomic era.Q36575949
Toll-like receptor signaling and its relevance to intestinal inflammationQ36631499
The role of T cells in periodontal disease: homeostasis and autoimmunityQ36703937
The role of reactive oxygen and antioxidant species in periodontal tissue destructionQ36703964
Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?Q36814065
Human variability in innate immunity.Q36938505
Pathogen subversion of cell-intrinsic innate immunityQ36977518
Mechanisms of evasion of complement by Porphyromonas gingivalis.Q36991739
Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosisQ36992344
IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?Q37015036
Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalisQ37015215
How microorganisms tip the balance between interleukin-12 family membersQ37033837
The use of rodent models to investigate host-bacteria interactions related to periodontal diseasesQ37058550
Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in miceQ37059185
Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivoQ37084615
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3.Q37097298
Subversion of innate immunity by periodontopathic bacteria via exploitation of complement receptor-3Q37113561
Th17 cells and rheumatoid arthritis--from the standpoint of osteoclast differentiation--.Q37143732
Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola.Q37144937
Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membraneQ37184540
Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriaeQ37200512
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transductionQ37217884
A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.Q37249268
Harmful molecular mechanisms in sepsisQ37273299
The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay.Q37285445
P433issue1
P921main subjecttoll-like receptorQ408004
P304page(s)141-162
P577publication date2010-02-01
P1433published inPeriodontology 2000Q15724648
P1476titleComplementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host
P478volume52

Reverse relations

cites work (P2860)
Q34238754Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia
Q34529487Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.
Q43584443Capsaicin inhibits Porphyromonas gingivalis growth, biofilm formation, gingivomucosal inflammatory cytokine secretion, and in vitro osteoclastogenesis
Q26797414Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches
Q92646754Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus
Q26862615Complement and dysbiosis in periodontal disease
Q37769810Complement and periodontitis.
Q36302901Complement-targeted therapeutics in periodontitis
Q29615484Complement: a key system for immune surveillance and homeostasis
Q34076596Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.
Q33807891Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host
Q45179456Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis
Q40537091FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.
Q30582298Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis
Q35596229Immune evasion strategies of Porphyromonas gingivalis.
Q50093319Immunohistochemical localization of TLR2 and CD14 in gingival tissue of healthy individuals and patients with chronic periodontitis
Q92155083Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?
Q36434353Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice.
Q54388410Interleukin-10 genotypes of the -1087 single nucleotide polymorphism influence sp1 expression in periodontitis lesions.
Q36417215Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist
Q36298474Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia
Q33715219Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis
Q41064612Molecular aspects of the pathogenesis of periodontitis.
Q33878479Oral microbial biofilm stimulation of epithelial cell responses.
Q35544574Pathogenic microbes and community service through manipulation of innate immunity
Q35155822Polymicrobial synergy and dysbiosis in inflammatory disease
Q99565599Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update
Q34290681Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats
Q34727808Role of complement in host-microbe homeostasis of the periodontium
Q41983427Severe periodontal disease associated with long-term treatment with intravenous immunoglobulin.
Q27677519Structure of Factor H-binding Protein B (FhbB) of the Periopathogen,Treponema denticola
Q24618908The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss
Q33729399The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function.
Q38231443The complement system and its role in the pathogenesis of periodontitis: current concepts.
Q34514076The inflammophilic character of the periodontitis-associated microbiota
Q30358263The link between periodontal disease and rheumatoid arthritis: an updated review.
Q36423082Toll-like receptor 4 expression in the epithelium of inflammatory periapical lesions. An immunohistochemical study
Q34399545Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products

Search more.