Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways.

scientific article published on 24 October 2013

Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDDIS.2013.406
P932PMC publication ID3920938
P698PubMed publication ID24157872
P5875ResearchGate publication ID258043097

P50authorRenato FrancoQ37376215
Daniele SantiniQ37837892
Michele CaragliaQ38321049
Claudio ArraQ39050534
Alfredo BudillonQ40122753
Elena Di GennaroQ57061563
Alessandra LeoneQ57629449
Antonio LucianoQ59674725
Francesca BruzzeseQ63737239
Maria Rita MiloneQ63737317
Chiara CiardielloQ86584762
P2093author name stringB Pucci
M Rocco
M I Chianese
P2860cites workThe DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitmentQ24537306
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen speciesQ28349324
p38 MAP-kinases pathway regulation, function and role in human diseasesQ29616303
Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myelomaQ30615908
Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitorsQ33697130
Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells.Q33962243
Novel therapies for metastatic castrate-resistant prostate cancerQ34249263
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.Q34363544
Endocrine therapy plus zoledronic acid in premenopausal breast cancer.Q34943802
Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteinsQ35264079
Molecular pathogenesis of multiple myeloma and its premalignant precursorQ36290238
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The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myelomaQ36709283
First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trialQ36804951
Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cellsQ36907149
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathwayQ37073682
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
Biochemical and molecular mechanisms of action of bisphosphonates.Q37812800
Pharmacokinetic evaluation of zoledronic acid.Q37874629
Pathways of chemotherapy resistance in castration-resistant prostate cancer.Q37874853
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Zoledronic acid significantly enhances radiation‑induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signalingQ39225762
HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT.Q39527047
Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acidQ39644602
Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosisQ39779497
Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexedQ39875582
Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitorsQ39976173
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitroQ40048123
Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cellsQ40079732
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cellsQ40104946
R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylationQ40189572
Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer.Q40344869
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylateQ40645503
EPN: a novel epithelial cell line derived from human prostate tissueQ40730255
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugsQ40945233
Breast-cancer adjuvant therapy with zoledronic acidQ42620139
A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.Q43136243
The pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with varying degrees of renal functionQ44343595
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancerQ44918129
Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.Q45258262
Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.Q46434787
Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-κB.Q46588819
Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month resultsQ87419544
P921main subjectprostate cancerQ181257
zoledronic acidQ218507
multiple myelomaQ467635
P304page(s)e878
P577publication date2013-10-24
P1433published inCell Death and DiseaseQ2197222
P1476titlePanobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways
P478volume4

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cites work (P2860)
Q54943211A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo.
Q38727632Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy.
Q29248583Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
Q33755160Exploiting Epigenetic Alterations in Prostate Cancer
Q91996955Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation
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Q42790822Molecular mechanisms of suberoylanilide hydroxamic acid in the inhibition of TGF-β1-mediated canine corneal fibrosis
Q38645501Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.
Q38717135Oxidative stress and proteasome inhibitors in multiple myeloma
Q28540022Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83
Q37692256Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells.
Q37190106Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.
Q34602263The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma
Q36946596Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression.
Q36962776Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

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