Nuclear EGFR as novel therapeutic target: insights into nuclear translocation and function

scientific article published on 28 December 2009

Nuclear EGFR as novel therapeutic target: insights into nuclear translocation and function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00066-009-2026-4
P698PubMed publication ID20082181

P2093author name stringClaus Mayer
H Peter Rodemann
Klaus Dittmann
P2860cites workHigh EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysisQ79947978
Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinomaQ95788188
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expressionQ24292840
Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptorQ24314620
Tyrosine phosphorylation controls PCNA function through protein stabilityQ24317732
Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cellsQ24319679
The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartmentQ28142021
A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunitQ28145489
The multiple faces of caveolaeQ29618099
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neckQ29619277
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.Q30437778
Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockadeQ33410126
Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.Q34326386
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expressionQ35094456
Mechanisms of DNA double strand break repair and chromosome aberration formationQ35783199
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancerQ35928801
Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosisQ35979121
Protein translocation across biological membranesQ36328629
Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expressionQ36798731
An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa) -induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review).Q36840684
Biology of interactions: antiepidermal growth factor receptor agentsQ36935078
The role of survivin for radiation therapy. Prognostic and predictive factor and therapeutic targetQ36981225
Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancerQ36992266
Radiation-induced EGFR-signaling and control of DNA-damage repairQ37024025
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcomaQ37104779
The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancerQ37235527
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancerQ37282661
Anti-epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today?Q37368697
Molecular targeted treatment and radiation therapy for rectal cancerQ37511793
Co-regulation of B-Myb expression by E2F1 and EGF receptorQ38318606
Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.Q39940485
Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulationQ40044976
Validation of HB-EGF and amphiregulin as targets for human cancer therapy.Q40049169
DNA double-strand break induction and repair in irradiated lymphoblastoid, fibroblast cell lines and white blood cells from ATM, NBS and radiosensitive patients.Q40097743
Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosisQ40104227
Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma.Q40133869
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptorQ40237882
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.Q40259700
Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear traffickingQ40331226
Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysisQ40395185
Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathwayQ40396956
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activityQ40396981
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinaseQ40401323
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.Q40467153
Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolaeQ40531770
Nuclear localization of EGF receptor and its potential new role as a transcription factorQ40782527
The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR.Q40899042
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agentsQ41077480
Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximabQ42524527
1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptorQ44104172
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylationQ45106730
Growth of intestinal epithelium in organ culture is dependent on EGF signallingQ45225450
Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC.Q45284781
Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma.Q46240826
Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective approach with low toxicity.Q46408833
Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarrayQ46535704
Out of breath, asleep at the wheelQ48481760
Search for heavy long-lived particles that decay to photons at CDF II.Q50891660
Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1.Q52578812
Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.Q53534489
C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability.Q53993143
Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cellsQ64389144
The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinomaQ73091527
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibodyQ73483324
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptorsQ78192920
Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancerQ79385733
P433issue1
P304page(s)1-6
P577publication date2009-12-28
P1433published inStrahlentherapie und OnkologieQ15724604
P1476titleNuclear EGFR as novel therapeutic target: insights into nuclear translocation and function
P478volume186

Reverse relations

cites work (P2860)
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