| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.BBAMCR.2011.04.003 |
| P8608 | Fatcat ID | release_bpylcda2dfavzotoigjt5jb6gy |
| P953 | full work available online at | https://api.elsevier.com/content/article/PII:S0167488911001182?httpAccept=text/plain |
| https://api.elsevier.com/content/article/PII:S0167488911001182?httpAccept=text/xml | ||
| https://doi.org/10.1016/j.bbamcr.2011.04.003 | ||
| P698 | PubMed publication ID | 21539865 |
| P5875 | ResearchGate publication ID | 51095743 |
| P2093 | author name string | Boudewijn M. T. Burgering | |
| David E. A. Kloet | |||
| P2860 | cites work | Mdm2 induces mono-ubiquitination of FOXO4 | Q21092186 |
| DNA Damage, Aging, and Cancer | Q22121931 | ||
| AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling | Q22241925 | ||
| AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 | Q22254000 | ||
| Insulin signalling and the regulation of glucose and lipid metabolism | Q24292020 | ||
| PDK1, the master regulator of AGC kinase signal transduction | Q24297416 | ||
| The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells | Q24314491 | ||
| 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1) | Q24322935 | ||
| C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span | Q24324828 | ||
| Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors | Q24537205 | ||
| FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis | Q24630630 | ||
| Signaling pathways perturbing muscle mass | Q37732100 | ||
| Integrating opposing signals toward Forkhead box O. | Q37771940 | ||
| Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. | Q39126224 | ||
| A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth | Q39703155 | ||
| TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia | Q39744014 | ||
| Cdk2 suppresses cellular senescence induced by the c-myc oncogene. | Q39763259 | ||
| Braf(V600E) cooperates with Pten loss to induce metastatic melanoma | Q39873596 | ||
| Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway | Q39896136 | ||
| C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells | Q39954044 | ||
| The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression | Q39958777 | ||
| Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins | Q39959273 | ||
| Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity | Q40016533 | ||
| The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors | Q40559475 | ||
| Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. | Q40564326 | ||
| A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells | Q40572608 | ||
| PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest | Q40702262 | ||
| A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. | Q40714220 | ||
| HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | Q40767550 | ||
| Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion | Q40935981 | ||
| Malignant transformation by overproduction of translation initiation factor eIF4G | Q41078786 | ||
| Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts | Q41176644 | ||
| Oncoprotein networks | Q41352439 | ||
| Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. | Q41680604 | ||
| Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth | Q42555007 | ||
| Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis | Q42601114 | ||
| FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. | Q42636934 | ||
| FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging | Q42705331 | ||
| A negative feedback signaling network underlies oncogene-induced senescence | Q43116108 | ||
| Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization | Q44592831 | ||
| Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair | Q46210604 | ||
| Insulin signal transduction through protein kinase cascades | Q48021735 | ||
| Autophagy is required to maintain muscle mass | Q51411361 | ||
| Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor | Q51455030 | ||
| Foxo3a is essential for maintenance of the hematopoietic stem cell pool. | Q51960990 | ||
| Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins. | Q53355278 | ||
| Tumor surveillance via the ARF–p53 pathway | Q53430438 | ||
| Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription | Q53541681 | ||
| Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway | Q53600237 | ||
| Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a | Q57277034 | ||
| Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background | Q58379806 | ||
| More than just proliferation: Myc function in stem cells | Q58379812 | ||
| PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention | Q59067116 | ||
| Low oxygen concentration extends the lifespan of cultured human diploid cells | Q59075443 | ||
| Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage | Q59098609 | ||
| Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | Q60284598 | ||
| c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability | Q74243929 | ||
| Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence | Q82021676 | ||
| FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor | Q24632191 | ||
| FoxO3 regulates neural stem cell homeostasis | Q24658086 | ||
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| A C. elegans mutant that lives twice as long as wild type | Q27861054 | ||
| Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins | Q28115923 | ||
| p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling | Q28117922 | ||
| Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice | Q28131756 | ||
| Loss of autophagy in the central nervous system causes neurodegeneration in mice | Q28131804 | ||
| The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans | Q28131830 | ||
| THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS | Q28202269 | ||
| Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer | Q28203143 | ||
| Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation | Q28208407 | ||
| p16INK4a induces an age-dependent decline in islet regenerative potential | Q28262230 | ||
| Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes | Q28265486 | ||
| FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis | Q28285131 | ||
| Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization | Q28290083 | ||
| Stressing the role of FoxO proteins in lifespan and disease | Q28303730 | ||
| Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene | Q28349476 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies | Q28590387 | ||
| Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a | Q28592736 | ||
| daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans | Q28611332 | ||
| Autophagy regulates lipid metabolism | Q29547421 | ||
| Autophagy genes are essential for dauer development and life-span extension in C. elegans | Q29614180 | ||
| FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells | Q29614482 | ||
| FoxO3 controls autophagy in skeletal muscle in vivo | Q29614483 | ||
| The role of the Atg1/ULK1 complex in autophagy regulation | Q29614497 | ||
| Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing | Q29615155 | ||
| Rejuvenation of aged progenitor cells by exposure to a young systemic environment | Q29615250 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| Cellular senescence: when bad things happen to good cells | Q29615561 | ||
| Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction | Q29618388 | ||
| Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | Q29618748 | ||
| Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy | Q29619282 | ||
| Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress | Q29619436 | ||
| Akt regulates growth by directly phosphorylating Tsc2 | Q29620397 | ||
| Regulation of translation initiation by FRAP/mTOR | Q29620398 | ||
| Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells | Q32084034 | ||
| Dynamic FoxO transcription factors | Q36889897 | ||
| A new mutational AKTivation in the PI3K pathway | Q36907930 | ||
| Cell turnover and adult tissue homeostasis: from humans to planarians. | Q37030822 | ||
| FOXO transcription factors in ageing and cancer. | Q37048803 | ||
| Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease | Q37089630 | ||
| Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. | Q37368307 | ||
| AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP? | Q37401922 | ||
| Should I stay or should I go: beta-catenin decides under stress | Q37408539 | ||
| PIKKing on PKB: regulation of PKB activity by phosphorylation | Q37419888 | ||
| Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase | Q37429675 | ||
| The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets | Q37457564 | ||
| Aging: central role for autophagy and the lysosomal degradative system | Q37475515 | ||
| FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. | Q37598769 | ||
| c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation | Q37620912 | ||
| Dysregulation of apoptosis in cancer | Q33773397 | ||
| Role of autophagy in suppression of inflammation and cancer | Q33802618 | ||
| AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. | Q33871498 | ||
| Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. | Q33917682 | ||
| Coexistence of quiescent and active adult stem cells in mammals | Q33926891 | ||
| JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. | Q33934548 | ||
| A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus | Q33944754 | ||
| c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points | Q33958488 | ||
| Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. | Q34084120 | ||
| PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization | Q34150579 | ||
| Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 | ||
| PKB/AKT: functional insights from genetic models | Q34389540 | ||
| JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling | Q34410199 | ||
| ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. | Q34479990 | ||
| Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity | Q34495990 | ||
| FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis | Q34504786 | ||
| Cellular senescence in cancer and aging | Q34581486 | ||
| How stem cells age and why this makes us grow old. | Q34667132 | ||
| The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice | Q34693888 | ||
| Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene | Q34958801 | ||
| Oncogenic Braf induces melanocyte senescence and melanoma in mice | Q34974162 | ||
| Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes | Q35038803 | ||
| Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. | Q35080744 | ||
| Human melanocyte senescence and melanoma susceptibility genes | Q35146545 | ||
| Cooperative effects of INK4a and ras in melanoma susceptibility in vivo | Q35195311 | ||
| Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis | Q35208288 | ||
| Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. | Q35267304 | ||
| Reversal of human cellular senescence: roles of the p53 and p16 pathways | Q35561999 | ||
| Telomeres, stem cells, senescence, and cancer | Q35628573 | ||
| eIF-4E expression and its role in malignancies and metastases. | Q35750118 | ||
| A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress | Q35847924 | ||
| Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression | Q35948212 | ||
| Stem cells, ageing and the quest for immortality. | Q36523915 | ||
| Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation | Q36835194 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1926-1937 | |
| P577 | publication date | 2011-04-27 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | The PKB/FOXO switch in aging and cancer | |
| P478 | volume | 1813 |
| Q35108152 | 2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin (TCDD) induces premature senescence in human and rodent neuronal cells via ROS-dependent mechanisms |
| Q42534340 | A pervasive role for MIG6 in restraining cell proliferation. |
| Q38853225 | AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms |
| Q38824661 | Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling |
| Q33732439 | Akt regulates TPP1 homodimerization and telomere protection |
| Q93086595 | C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene |
| Q35168191 | Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells |
| Q36907910 | Differentiation of CD8 memory T cells depends on Foxo1 |
| Q37600074 | Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis |
| Q58005048 | FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation |
| Q36184673 | FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). |
| Q42147114 | FOXO1 regulates expression of a microRNA cluster on X chromosome |
| Q24293774 | FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C‐myc |
| Q38074598 | FOXOs: signalling integrators for homeostasis maintenance |
| Q43095652 | Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions |
| Q39000854 | Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. |
| Q39256405 | Foxd1 is a mediator and indicator of the cell reprogramming process |
| Q38812476 | Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis |
| Q37706206 | GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer |
| Q38972581 | GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4 |
| Q39206484 | Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling |
| Q91639506 | High expression of FOXO3 is associated with poor prognosis in patients with hepatocellular carcinoma |
| Q34559494 | High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway |
| Q39265034 | Inhibition of H2O2-induced cell death through FOXO1 modulation by EUK-172 in SK-N-MC cells |
| Q28507173 | Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition |
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| Q36005664 | Mechanistic insights into aging, cell-cycle progression, and stress response. |
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| Q36033922 | Modeling the interplay between the HIF-1 and p53 pathways in hypoxia |
| Q38779851 | Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. |
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| Q40188778 | Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway |
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