Immunobiology of β-Cell Destruction

scientific article published on January 1, 2012

Immunobiology of β-Cell Destruction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/978-1-4614-5441-0_16
P953full work available online athttp://link.springer.com/content/pdf/10.1007/978-1-4614-5441-0_16
P698PubMed publication ID23393680

P2093author name stringDaria La Torre
P2860cites workJournal of Clinical InvestigationQ3186904
American Journal of Human GeneticsQ4744249
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetesQ79553721
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetesQ79843142
Reduced IFN-alpha secretion by blood dendritic cells in human diabetesQ79963070
From vanilla to 28 flavors: multiple varieties of T regulatory cellsQ80141724
Decreased blood dendritic cell counts in type 1 diabetic childrenQ80226211
Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashionQ81008941
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetesQ81464244
Detection of enteroviruses in the intestine of type 1 diabetic patientsQ81572286
Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general populationQ81716770
Altered Toll-like receptor signaling pathways in human type 1 diabetesQ84775923
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICAQ22010440
CD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Interleukin-10 and the interleukin-10 receptorQ24290912
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesQ24632382
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesQ24675521
CTLA-4 ligation blocks CD28-dependent T cell activationQ24678229
APC-derived cytokines and T cell polarization in autoimmune inflammationQ24679426
T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental AgentsQ27485358
Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigenQ28210683
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficienciesQ28237011
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TH17 cells in development: an updated view of their molecular identity and genetic programmingQ28276449
Environmental triggers and determinants of type 1 diabetesQ28283357
The HLA-DR phenotype modulates the humoral immune response to enterovirus antigensQ73621908
Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetesQ73810102
Development of type 1 diabetes despite severe hereditary B-cell deficiencyQ74593633
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB StudyQ74607777
Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY)Q75346111
High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetesQ78290524
Association of the PTPN22/LYP gene with type 1 diabetesQ79281980
Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosisQ79370236
T-cell activation through immunological synapses and kinapsesQ37084875
The Foxp3+ regulatory T cell: a jack of all trades, master of regulationQ37088900
IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cellsQ37089982
The natural history of type 1A diabetesQ37148312
Advances in type I diabetes associated tolerance mechanismsQ37164758
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosisQ37193767
Interactions between B-lymphocytes and type 1 NKT cells in autoimmune diabetesQ37196719
Autoimmune mechanisms in type 1 diabetesQ37215820
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-AQ37245361
IL-1 produced and released endogenously within human islets inhibits beta cell functionQ37384207
Role of innate immunity in triggering and tuning of autoimmune diabetesQ37387450
Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.Q37400735
AireQ37419376
Histopathology of type 1 diabetes: old paradigms and new insightsQ37425106
The role of inflammation in insulitis and beta-cell loss in type 1 diabetesQ37437153
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitusQ37518209
ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onsetQ37520312
Are B cells a potential target for therapeutic intervention in the classical T cell-mediated autoimmune disease type 1 diabetes?Q37521124
Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery.Q37779881
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Cow's milk exposure and type I diabetes mellitus. A critical overview of the clinical literatureQ38569312
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Testing the NKT cell hypothesis of human IDDM pathogenesisQ39738424
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration studyQ39975295
Determinant spreading and the dynamics of the autoimmune T-cell repertoire.Q40487702
Heterogeneity of islet pathology in two infants with recent onset diabetes mellitusQ40494326
Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patientQ40607014
Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitopeQ40720812
Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life.Q40724749
Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assaysQ40797897
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLsQ41057373
Adhesion molecules in autoimmune diseaseQ41133422
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseasesQ43089300
Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project GroupQ43607374
Dietary microbial toxins and type 1 diabetes--a new meaning for seed and soilQ43763539
Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide productionQ43867519
A six-fold gradient in the incidence of type 1 diabetes at the eastern border of FinlandQ43899034
Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the diseaseQ44110178
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetesQ44616498
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.Q44876645
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjectsQ44887481
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjectsQ44914587
CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitopeQ44937301
Milk Proteins in the Etiology of Insulin-Dependent Diabetes Mellitus (IDDM)Q36689792
Identification of novel IGRP epitopes targeted in type 1 diabetes patients.Q36725757
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetesQ36755911
The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypesQ36807498
Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.Q36815557
PD-1 and PD-1 ligands: from discovery to clinical applicationQ36868261
Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twinsQ36905127
B-cell self-tolerance in humansQ36942517
Dendritic cells: understanding immunogenicityQ36986703
Role of plasmacytoid dendritic cells in type 1 diabetes: friend or foe?Q37022995
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex captureQ37023012
Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetesQ37066897
Multiple immuno-regulatory defects in type-1 diabetesQ28344695
Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organsQ28359868
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretionQ28510538
Autoantibodies to the islet antigen ICA 69 occur in IDDM and in rheumatoid arthritisQ29011023
T-Cell Function and Migration — Two Sides of the Same CoinQ29041098
FOXP3+ regulatory T cells in the human immune systemQ29307487
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetesQ29417127
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
Report of the Expert Committee on the Diagnosis and Classification of Diabetes MellitusQ29616284
The effect of infections on susceptibility to autoimmune and allergic diseasesQ29618525
Results of the MHC fine mapping workshop.Q30438545
Genetics of type 1A diabetesQ30448199
Antibodies to SOX13 (ICA12) are associated with type 1 diabetes.Q30660084
Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trendsQ31473026
Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinantsQ33199893
Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.Q33321888
Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetesQ33383716
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.Q33586528
Developmental control of CD8 T cell-avidity maturation in autoimmune diabetesQ33840423
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patientsQ33907823
The Environmental Determinants of Diabetes in the Young (TEDDY) StudyQ33917733
Childhood Vaccinations, Vaccination Timing, and Risk of Type 1 Diabetes MellitusQ34103885
Information transfer at the immunological synapse.Q34117443
CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?Q34150490
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetesQ34159440
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetesQ34234705
Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunityQ34262463
Early Infant Feeding and Risk of Developing Type 1 Diabetes–Associated AutoantibodiesQ34266396
T cell-dependent B cell activationQ34363600
Enterovirus RNA in blood is linked to the development of type 1 diabetesQ34448707
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosisQ34495385
Tolerogenic dendritic cells: cytokine modulation comes of age.Q34523591
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.Q34553677
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
Screening for insulitis in adult autoantibody-positive organ donorsQ34580251
Viral infections as potential triggers of type 1 diabetesQ34581550
A genome-wide association study identifies KIAA0350 as a type 1 diabetes geneQ34651283
Historical insights into cytokinesQ34708047
Environmental factors in the etiology of type 1 diabetesQ34737247
Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cellsQ34737266
Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetesQ34737274
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetesQ34790295
Viral trigger for type 1 diabetes: pros and consQ34868678
Analysis of islet inflammation in human type 1 diabetes.Q34917032
The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.Q34957941
A new look at viruses in type 1 diabetes.Q35068487
Dietary factors and the risk of developing insulin dependent diabetes in childhoodQ35169227
Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetesQ35172147
A comprehensive guide to antibody and T-cell responses in type 1 diabetes.Q35583448
Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitusQ35608673
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in healthQ35632007
MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, deleteQ35718644
Environmental causes: dietary causesQ35725717
Tissue targeting of T cells by DCs and microenvironmentsQ35846381
Toward an understanding of NKT cell biology: progress and paradoxesQ36072480
Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigensQ36111731
Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylaseQ36202374
Immunoregulation of dendritic cellsQ36256306
Cross-presentation: underlying mechanisms and role in immune surveillanceQ36266474
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetesQ36310443
Autoimmune destruction of pancreatic beta cells.Q36310464
Type 1 diabetes mellitus: etiology, presentation, and managementQ36318729
Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetesQ36364761
The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetesQ36535592
Autoantibody markers for the diagnosis and prediction of type 1 diabetesQ36557401
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity.Q36563563
A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop.Q36666034
NK cells and type 1 diabetesQ36680559
A fifty-year follow-up of congenital rubellaQ45094875
A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex familiesQ45138861
Elevated Levels of Circulating Adhesion Molecules in IDDM Patients and in Subjects at Risk for IDDMQ45236628
Detection of autoreactive T cells in type 1 diabetes using coded autoantigens and an immunoglobulin-free cytokine ELISPOT assay: report from the fourth immunology of diabetes society T cell workshopQ45256424
No Evidence for an Association of Coxsackie Virus Infections during Pregnancy and Early Childhood with Development of Islet Autoantibodies in Offspring of Mothers or Fathers with Type 1 DiabetesQ45734292
Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM.Q45771753
Coxsackie B virus infection and onset of childhood diabetesQ45787981
Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes.Q46009178
The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.Q46085427
Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.Q46677005
Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytesQ46739819
The epidemiology of type 1 diabetes in children in Philadelphia 1990-1994: evidence of an epidemicQ46953270
Good riddance: Thymocyte clonal deletion prevents autoimmunityQ47946468
Immunology in diabetes: an updateQ48030355
Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes: effects on insulin release from human islets.Q51559700
Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birthQ51717930
Evidence for immunological priming and increased frequency of CD4+ CD25+ cord blood T cells in children born to mothers with type 1 diabetesQ51977695
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetesQ52196097
Insulin autoantibodies and insulin antibodies have similar binding characteristicsQ52227031
Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunityQ54084991
Altered natural killer cells in type 1 diabetic patientsQ54565253
Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitusQ54568509
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.Q55044269
Interferons induce an antiviral state in human pancreatic islet cellsQ56875360
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetesQ56902091
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetesQ56904461
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groupsQ56908296
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjectsQ57158887
Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodiesQ57449132
Poor In Vitro Maturation and Pro-Inflammatory Cytokine Response of Dendritic Cells in Children at Genetic Risk of Type 1 DiabetesQ57449379
Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell FunctionQ57491711
Islet inflammation and CXCL10 in recent-onset type 1 diabetesQ57503559
Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomesQ58470464
Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetesQ61861625
Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort studyQ64378313
In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitisQ67296143
Feeding in infancy and the risk of type 1 diabetes mellitus in Finnish children. The 'Childhood Diabetes in Finland' Study GroupQ67975292
Anti-pancreatic, cellular hypersensitivity in diabetes mellitus. Experimental induction of anti-pancreatic, cellular hypersensitivity and associated morphological B-cell changes in the ratQ69324742
Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of LangerhansQ70291006
Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetesQ71557208
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitusQ71670371
Autoantibodies to IA-2 in IDDM: location of major antigenic determinantsQ71909260
Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Childhood Diabetes in Finland Study GroupQ72793959
Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cellsQ73048880
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitusQ73153922
Type 1 diabetes alters anti-hsp90 autoantibody isotypeQ73407950
Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre case-control investigation. EURODIAB Substudy 2 Study GroupQ73420339
T cells and autoantibodies to human HSP70 in type 1 diabetes in childrenQ73489749
P407language of work or nameEnglishQ1860
P304page(s)194-218
P577publication date2012-01-01
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleImmunobiology of beta-cell destruction
Immunobiology of β-Cell Destruction
P478volume771

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