Molecular basis of organ fibrosis: potential therapeutic approaches

scientific article published on May 2013

Molecular basis of organ fibrosis: potential therapeutic approaches is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1535370213489441
P698PubMed publication ID23856899

P50authorAsish K GhoshQ91313744
P2093author name stringDouglas E Vaughan
Susan E Quaggin
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TGF-beta signal transductionQ22003891
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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingQ24633454
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Cellular and molecular mechanisms of fibrosisQ24648892
Pathways of Egr-1-mediated gene transcription in vascular biologyQ24671655
Regulation of endothelial cell plasticity by TGF-βQ26862059
MyofibroblastsQ27022840
Role of transforming growth factor beta in human diseaseQ28143408
The mechanisms of action of PPARsQ28216953
Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylationQ28249959
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
TGFβ signalling in contextQ28275410
Augmented Wnt signaling in a mammalian model of accelerated agingQ28506533
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblastsQ28511032
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Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosisQ28568441
Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effectsQ28570037
Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblastsQ28584045
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorQ29547912
Endothelial-to-mesenchymal transition contributes to cardiac fibrosisQ29620566
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Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.Q30499402
Chemical phylogenetics of histone deacetylasesQ30977637
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosisQ33643242
Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10Q33719352
Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivatorQ37326935
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.Q37417291
Fibroproliferative disorders.Q37647584
Shifting players and paradigms in cell-specific transcriptionQ37671910
Clinical Use of Interferon-gammaQ37675044
PAI-1 in tissue fibrosisQ37861626
Non-Smad signaling pathwaysQ37893980
Klotho in health and diseaseQ38015713
Wound repair and regenerationQ38026474
MicroRNAs, transforming growth factor beta-1, and tissue fibrosis.Q38050081
Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolutionQ38055448
Histone lysine methylation dynamics: establishment, regulation, and biological impactQ38064095
Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosisQ38300936
The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expressionQ38313294
Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstructionQ38317847
Inhibition of collagen gene expression by interferon-gamma: novel role of the CCAAT/enhancer binding protein beta (C/EBPbeta).Q38318024
Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cellsQ38326907
Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic ratsQ38333959
Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosisQ38352858
Anti-inflammatory and antifibrotic effects of methyl palmitateQ39541716
Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansionQ39554276
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytesQ39690407
Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosisQ39713121
TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.Q39737677
Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppressionQ39817587
Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cellsQ39939184
Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cellsQ40373054
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53Q40395907
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300Q40445183
S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytesQ40649351
Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) ratsQ40738851
Changes in p53 expression in mouse fibroblasts can modify motility and extracellular matrix organization.Q40835991
Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.Q41094631
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiationQ41774831
The induction of CCN2 by TGFbeta1 involves Ets-1.Q41849541
Modulation of human alpha1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitroQ42458261
Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gammaQ42459998
The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cellsQ42466997
CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activityQ42481241
Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivatorsQ42491309
Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.Q42509474
Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosisQ42516749
Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma activationQ42518271
Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.Q42590202
Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transitionQ42775592
Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcriptionQ42795742
Connective tissue growth factor is induced in bleomycin-induced skin sclerodermaQ42917225
Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.Q43140361
Transcription factor Sp1 expression is upregulated in human glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injuryQ43144139
Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injuryQ43244113
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.Q43877873
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in miceQ43882371
Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro.Q43936714
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.Q44021747
IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathwayQ44397955
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in ratsQ44507331
Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in ratsQ44963004
Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytesQ45054700
Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene programQ45184208
Antifibrotic effect of interferon gamma in silicosis model of rat.Q45223247
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO modelQ45862411
Antifibrotic effect via the regulation of transcription factor Sp1 in lung fibrosisQ45871071
Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transitionQ45877659
Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats.Q45933449
Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.Q46021850
Tomio Tada 1934-2010.Q48461688
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.Q52617872
Characterization of the phenotype of high collagen-producing fibroblast clones in systemic sclerosis, using a new modified limiting-dilution method.Q53169053
Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21.Q53398171
Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1.Q53576576
Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition.Q54412343
Sp1 and Sp3 transcription factors mediate leptin-induced collagen α1(I) gene expression in primary culture of male rat hepatic stellate cells.Q54475608
Effects of N-n-butyl haloperidol iodide on myocardial ischemia/reperfusion injury and Egr-1 expression in rat.Q54597915
Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in ratsQ56534241
A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary cultureQ57228777
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesisQ33745028
Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblastsQ33760755
TGF-beta and fibrosisQ33804142
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in miceQ33853415
Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient miceQ33882433
Tumor suppressor p53: regulation and functionQ33890466
Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblastsQ33923496
Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophyQ33929939
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause diseaseQ33942130
Deficient Smad7 expression: a putative molecular defect in sclerodermaQ34021184
p53 at a glanceQ34029735
Aging mechanismsQ34062964
PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancerQ34106716
miR-192 mediates TGF-beta/Smad3-driven renal fibrosisQ34124178
Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitroQ34170852
MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous sclerodermaQ34252230
Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptionalQ34263054
Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expressionQ34371002
An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.Q34378178
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in ratsQ34414756
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in miceQ34514594
Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.Q34542559
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in miceQ34624546
The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosisQ34636005
In preeclampsia endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteriesQ34647825
New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axisQ34720147
Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosisQ34805635
Early growth response (EGR)-1 is required for timely cell-cycle entry and progression in hepatocytes after acute carbon tetrachloride exposure in mice.Q35057036
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of sclerodermaQ35102837
Interleukin-10 therapy--review of a new approachQ35139563
Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gammaQ35170133
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activationQ35205960
Identification of a microRNA signature in renal fibrosis: role of miR-21.Q35326035
Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.Q35626103
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseasesQ35649473
Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 actionQ35677699
Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosisQ35684759
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferationQ35684848
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γQ35694487
p300/CBP and cancerQ35779695
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in miceQ35787690
Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skinQ35791840
The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.Q35924490
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.Q35968237
Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failureQ35968905
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.Q36048656
Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in miceQ36089631
Transcription initiation by human RNA polymerase II visualized at single-molecule resolutionQ36162657
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κBQ36174897
CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in miceQ36188234
Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction.Q36189271
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cellsQ36263679
The many faces of PPARgammaQ36344625
Plasma klotho and cardiovascular disease in adultsQ36364310
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosisQ36399732
Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarctionQ36446530
Transforming growth factor-beta and the immune systemQ36457999
Klotho protects against mouse renal fibrosis by inhibiting Wnt signalingQ36494436
p53 is renoprotective after ischemic kidney injury by reducing inflammation.Q36509298
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cellsQ36558691
Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAsQ36673667
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signallingQ36678523
p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.Q36767089
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.Q36769644
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensinQ37071681
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gammaQ37071874
Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathyQ37190292
P433issue5
P304page(s)461-481
P577publication date2013-05-01
P1433published inExperimental Biology and MedicineQ15716535
P1476titleMolecular basis of organ fibrosis: potential therapeutic approaches
P478volume238

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