| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Sharad Kumar | Q37380153 |
| P2093 | author name string | Pranay Goel | |
| Jantina A Manning | |||
| P2860 | cites work | Nedd4-2 does not regulate wt-CFTR in human airway epithelial cells | Q36312479 |
| HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway | Q36321265 | ||
| HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation | Q36708554 | ||
| Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2). | Q37048433 | ||
| The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism | Q37176369 | ||
| Mechanisms of ENaC regulation and clinical implications | Q37254732 | ||
| Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases | Q37269148 | ||
| Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway | Q37375772 | ||
| Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1). | Q37722889 | ||
| Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK. | Q38017464 | ||
| Linear ubiquitination: a newly discovered regulator of cell signalling | Q38075345 | ||
| Characteristics and regulatory mechanisms of the amiloride-blockable Na+ channel | Q38187242 | ||
| Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2. | Q38308064 | ||
| Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma | Q39031391 | ||
| MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression | Q39080347 | ||
| The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways | Q39371861 | ||
| Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer | Q39637494 | ||
| The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel | Q24290914 | ||
| The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction | Q24292709 | ||
| Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels | Q24294569 | ||
| Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 | Q24295274 | ||
| The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family | Q24296263 | ||
| Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination | Q24297821 | ||
| Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1 | Q24298918 | ||
| Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development | Q24299364 | ||
| Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2 | Q24311310 | ||
| A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase | Q24313174 | ||
| Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III | Q24317311 | ||
| The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels | Q24328849 | ||
| WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome | Q24563029 | ||
| The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif | Q24596374 | ||
| Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 | Q24623513 | ||
| Respiratory distress and perinatal lethality in Nedd4-2-deficient mice | Q24629880 | ||
| E3 ligase Nedd4 promotes axon branching by downregulating PTEN | Q24630190 | ||
| Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins | Q24645749 | ||
| Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+ | Q24647839 | ||
| Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions | Q24651528 | ||
| Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons | Q24657218 | ||
| Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel | Q24657768 | ||
| Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb | Q24685954 | ||
| Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors | Q26825006 | ||
| Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming | Q27684556 | ||
| The ubiquitin system | Q27860803 | ||
| Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. | Q27939550 | ||
| All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+ | Q28142056 | ||
| Identification of a set of genes with developmentally down-regulated expression in the mouse brain | Q28187594 | ||
| Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits | Q28249570 | ||
| N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking | Q28271953 | ||
| Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain | Q28281054 | ||
| WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65 | Q28304450 | ||
| The rsp5-domain is shared by proteins of diverse functions | Q28305776 | ||
| Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases | Q28505178 | ||
| Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2 | Q28511126 | ||
| A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel | Q28512481 | ||
| Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease | Q28512734 | ||
| Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein | Q28564648 | ||
| Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays | Q28566104 | ||
| Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2 | Q28576167 | ||
| Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels | Q28576474 | ||
| Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2 | Q28581935 | ||
| Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling | Q28582384 | ||
| Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia | Q28587281 | ||
| In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA | Q28589735 | ||
| Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2 | Q28591738 | ||
| N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein | Q28594273 | ||
| Physiological functions of the HECT family of ubiquitin ligases | Q29617293 | ||
| The ubiquitin-proteasome pathway: on protein death and cell life | Q29619270 | ||
| Protein regulation by monoubiquitin | Q29620221 | ||
| Epithelial Na+ channel subunit stoichiometry | Q30499923 | ||
| The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding | Q33417652 | ||
| Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions | Q33632965 | ||
| Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C | Q33658812 | ||
| DEG/ENaC channels: a touchy superfamily that watches its salt | Q33725682 | ||
| Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes | Q33748196 | ||
| Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma. | Q33753890 | ||
| Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation | Q33885179 | ||
| c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells | Q34094432 | ||
| Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel | Q34100646 | ||
| NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene. | Q34113703 | ||
| The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels | Q34158333 | ||
| Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins | Q39935364 | ||
| Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. | Q40021104 | ||
| Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding | Q40418986 | ||
| Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases | Q40437388 | ||
| 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. | Q40464497 | ||
| NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor | Q40501781 | ||
| Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference | Q40612889 | ||
| The CFTR and ENaC debate: how important is ENaC in CF lung disease? | Q41999718 | ||
| Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. | Q42100274 | ||
| Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation | Q42157885 | ||
| Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain | Q43206153 | ||
| Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1. | Q43240938 | ||
| Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma | Q43539447 | ||
| Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. | Q43807758 | ||
| Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. | Q44912987 | ||
| WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter | Q45361616 | ||
| A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. | Q45918466 | ||
| Role of CFTR in airway disease | Q47606626 | ||
| Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases. | Q48599640 | ||
| Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. | Q48752231 | ||
| Genetic risk variants for dyslexia on chromosome 18 in a German cohort. | Q50738677 | ||
| Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct. | Q54664151 | ||
| Ubiquitin adenylate: structure and role in ubiquitin activation | Q70168206 | ||
| Mutations in the surfactant protein C gene associated with interstitial lung disease | Q77763687 | ||
| Ubiquitin and the control of protein fate in the secretory and endocytic pathways | Q77803382 | ||
| 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes | Q79761759 | ||
| RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis | Q80050588 | ||
| Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study | Q80754427 | ||
| 14-3-3 proteins: a number of functions for a numbered protein | Q81038465 | ||
| The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities | Q81594841 | ||
| A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients | Q82317917 | ||
| Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia | Q82584279 | ||
| The ESCRT pathway and HIV-1 budding | Q83185686 | ||
| Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient | Q84935997 | ||
| Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death | Q86858190 | ||
| Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript | Q34169816 | ||
| Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2. | Q34177064 | ||
| Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. | Q34221348 | ||
| Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells | Q34276421 | ||
| Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain. | Q34302628 | ||
| Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. | Q34318302 | ||
| Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension | Q34324276 | ||
| Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects | Q34336329 | ||
| cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2. | Q34343216 | ||
| Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. | Q34351740 | ||
| Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells | Q34359643 | ||
| Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases | Q34360667 | ||
| Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins | Q34368660 | ||
| Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons | Q34379768 | ||
| Nedd4-2 isoforms differentially associate with ENaC and regulate its activity. | Q34409388 | ||
| cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. | Q34419826 | ||
| NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling | Q34420227 | ||
| AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells | Q34426341 | ||
| Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. | Q34435174 | ||
| Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. | Q34442840 | ||
| Association of NEDD4L ubiquitin ligase with essential hypertension | Q34443485 | ||
| Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins | Q34525938 | ||
| 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels. | Q34529071 | ||
| (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms | Q34570818 | ||
| Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1. | Q34624572 | ||
| Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. | Q34717463 | ||
| Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension | Q34749197 | ||
| NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains | Q34758977 | ||
| Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer | Q34787147 | ||
| Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling | Q35013177 | ||
| Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway | Q35210213 | ||
| The ubiquitin-conjugation system | Q35237882 | ||
| Occludin: structure, function and regulation | Q36093750 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | membrane protein | Q423042 |
| P304 | page(s) | 1-10 | |
| P179 | part of the series | Gene Wiki Review Series | Q108807010 |
| P577 | publication date | 2014-11-26 | |
| P1433 | published in | Gene | Q5531065 |
| P1476 | title | NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins | |
| P478 | volume | 557 |
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| Q91722534 | IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway |
| Q48025677 | Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells |
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| Q37378038 | Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia |
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| Q37745115 | Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model |
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| Q97519821 | The Global Phosphorylation Landscape of SARS-CoV-2 Infection |
| Q37393354 | The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
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| Q52584557 | The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L. |
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