Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies

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Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies is …
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scholarly articleQ13442814

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P356DOI10.1139/BCB-2014-0107
P698PubMed publication ID25607236
P5875ResearchGate publication ID271332673

P2093author name stringLi Chen
Grant M Hatch
Wenguang Chang
P2860cites workEfficacy of berberine in patients with type 2 diabetes mellitusQ24645248
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Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral CortexQ28533983
Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injuryQ28542840
Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liverQ28564768
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expressionQ28568493
Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathwayQ28573256
Adipocyte differentiation from the inside outQ29615690
Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2Q42806157
Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizomaQ42811484
Safety evaluation of main alkaloids from Rhizoma CoptidisQ42828656
Berberine stimulates glucose transport through a mechanism distinct from insulin.Q42831138
Berberine inhibits adipogenesis in high-fat diet-induced obesity miceQ42832699
Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathwayQ42963879
Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studiesQ43234180
Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocinQ43290690
Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathwayQ44036628
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic ratsQ44118197
Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic ratsQ44331287
The antihyperglycaemic activity of berberine arises from a decrease of glucose absorptionQ44536650
Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretionQ46092152
Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signalingQ46480430
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineQ46656835
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionQ46745033
Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humansQ47957732
Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patientsQ50522082
Berberine rescues D-galactose-induced synaptic/memory impairment by regulating the levels of Arc.Q50702639
Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic ratsQ51348247
Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocinQ51358502
Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liverQ51369549
Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathwayQ51371566
Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in ratsQ53264353
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated AtherosclerosisQ56991358
Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in ratsQ33246062
Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2Q34043189
The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes SocietyQ34292435
Displacement of bilirubin from albumin by berberineQ34366662
Cardiovascular and metabolic effects of BerberineQ34390654
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activityQ34603754
Type 2 diabetes in children: clinical aspects and risk factorsQ34616312
Youth-onset type 2 diabetes mellitus: lessons learned from the TODAY studyQ35057449
ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathyQ35182347
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesisQ36006541
Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic controlQ36175416
The molecular basis for oxidative stress-induced insulin resistanceQ36184182
Berberine Ameliorates Cold and Mechanical Allodynia in a Rat Model of Diabetic NeuropathyQ36933488
Clinical presentation and treatment of type 2 diabetes in childrenQ36996546
Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trialQ37042471
Berberine behind the thriller of marked symptomatic bradycardiaQ37043236
Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesisQ37227111
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes.Q37337259
The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked MiceQ37513209
Neuropharmacological and pharmacokinetic properties of berberine: a review of recent researchQ37546190
The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complicationsQ37903726
Berberine‐induced Haemolysis Revisited: Safety of Rhizoma coptidis and Cortex phellodendri in Chronic Haematological DiseasesQ37946266
Metformin therapy and kidney disease: a review of guidelines and proposals for metformin withdrawal around the worldQ38130189
Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver diseaseQ38199526
Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailabilityQ38418180
Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinaseQ38421650
Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat HeartQ38422854
Global estimates of diabetes prevalence for 2013 and projections for 2035.Q39231145
Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cellsQ39370584
Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophagesQ39714531
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expressionQ39792130
Berberine-induced LDLR up-regulation involves JNK pathway.Q40085868
Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.Q40218653
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticlesQ42000200
Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytesQ42521110
Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathwayQ42798170
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)479-486
P577publication date2014-12-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inBiochemistry and Cell BiologyQ4914719
P1476titleBerberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies
P478volume93

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cites work (P2860)
Q89512877Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment
Q28550972Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway
Q47753138Berberine Inhibits Oxygen Consumption Rate Independent of Alteration in Cardiolipin Levels in H9c2 Cells
Q49834498Berberine activates bitter taste responses of enteroendocrine STC-1 cells
Q36790209Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells
Q88092282Berberine enhances antidiabetic effects and attenuates untoward effects of canagliflozin in streptozotocin-induced diabetic mice
Q64084960Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Q92621370Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell
Q38773397Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR-203.
Q90285326Berberine protects steatotic donor undergoing liver transplantation via inhibiting endoplasmic reticulum stress-mediated reticulophagy
Q47139281Berberis integerrima ameliorates insulin resistance in high- fructose-fed insulin-resistant rats
Q88419158Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential
Q55017149Composition and diversity of rhizosphere fungal community in Coptis chinensis Franch. continuous cropping fields.
Q46307017Could hop-derived bitter compounds improve glucose homeostasis by stimulating the secretion of GLP-1?
Q92826828Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines
Q51019283Effects of type 2 diabetes mellitus on the pharmacokinetics of berberine in rats
Q60955679Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins
Q39374045Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes.
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Q64114596Preparation and Characterization of Erythrocyte Membrane-Camouflaged Berberine Hydrochloride-Loaded Gelatin Nanoparticles
Q42434705Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography
Q42492483The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells
Q64354593The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

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