Sphingolipids and mitochondrial apoptosis

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Sphingolipids and mitochondrial apoptosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1016670905
P356DOI10.1007/S10863-015-9602-3
P8608Fatcat IDrelease_fhcx43zu7rf7xbfqnvkpvnxree
P932PMC publication ID5434644
P698PubMed publication ID25620271

P2093author name stringLevi J Beverly
Leah J Siskind
Gauri A Patwardhan
P2860cites workMolecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoformQ22253469
Molecular cloning and characterization of a human mitochondrial ceramidaseQ22253989
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramideQ24291239
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)Q24296689
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERTQ24299291
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis inductionQ24320479
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processingQ24321239
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signallingQ24337047
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.Q55475037
Ceramide-mediated clustering is required for CD95-DISC formationQ57369954
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosisQ57373873
Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2Q57580273
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen SpeciesQ58116814
Galectin-1 Sensitizes Resting Human T Lymphocytes to Fas (CD95)-mediated Cell Death via Mitochondrial Hyperpolarization, Budding, and FissionQ60687731
Programmed cell death induced by ceramideQ70619078
Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramideQ72571243
Loss of ceramide production confers resistance to radiation-induced apoptosisQ73221177
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicinQ73552333
Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activationQ73565991
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosisQ73596247
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramideQ73717907
Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosisQ73755392
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosisQ77772579
BCL-2 suppresses ceramide-induced cell killingQ79442727
Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosisQ83304766
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1Q24337386
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytesQ24602345
Ceramide synthases at the centre of sphingolipid metabolism and biologyQ24609859
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathyQ24634622
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteinsQ24646241
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrationsQ24646262
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cellsQ24646847
Movement of Bax from the cytosol to mitochondria during apoptosisQ24677881
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosisQ24679716
Xanthurenic acid translocates proapoptotic Bcl-2 family proteins into mitochondria and impairs mitochondrial functionQ24795184
Export of sphingosine-1-phosphate and cancer progressionQ27009557
Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cellsQ27314745
The targeting of plasmalemmal ceramide to mitochondria during apoptosisQ27323504
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisQ27675952
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosisQ28139061
Human acid ceramidase: processing, glycosylation, and lysosomal targetingQ28206182
Fatal liaisons of p53 with Bax and BakQ28259716
Principles of bioactive lipid signalling: lessons from sphingolipidsQ28265743
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signalsQ28295232
Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosisQ28343579
Propagation of the apoptotic signal by mitochondrial wavesQ28345086
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissuesQ28512628
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant miceQ28512884
PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide productionQ28570099
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alphaQ28572338
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramidesQ28587980
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisQ28588618
Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5Q28590499
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosisQ28854340
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responsesQ29616076
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomasQ30492014
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cellsQ33183746
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
A lipid binding domain in sphingosine kinase 2Q37132627
Targeting SphK1 as a new strategy against cancerQ37172893
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide ChannelsQ37269319
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalizationQ37312126
Ceramide and mitochondria in ischemia/reperfusionQ37344754
Roles and regulation of secretory and lysosomal acid sphingomyelinaseQ37454661
Bcl-2 interrupts the ceramide-mediated pathway of cell death.Q37583838
Ceramide channels and their role in mitochondria-mediated apoptosisQ37681098
Regulation of ceramide channels by Bcl-2 family proteinsQ37693262
Regulation of sphingosine kinase and sphingolipid signaling.Q37792598
Sphingolipids and expression regulation of genes in cancer.Q37802552
The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sitesQ37862984
A view on sphingolipids and diseaseQ37875474
Targeting sphingosine kinase 1 in cancerQ37906002
The role of sphingolipids in respiratory diseaseQ37928817
Heart sphingolipids in health and disease.Q37930545
Ceramide and mitochondria in ischemic brain injury.Q37970353
Sphingolipids: critical players in Alzheimer's diseaseQ38029867
Mitochondria: master regulators of danger signallingQ38061862
Regulation of the sphingosine kinase/sphingosine 1-phosphate pathwayQ38096845
Membrane channels formed by ceramideQ38098408
Ceramide synthases as potential targets for therapeutic intervention in human diseasesQ38136056
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidaseQ38142501
Sphingosine kinase and sphingosine-1-phosphate: regulators in autoimmune and inflammatory diseaseQ38177794
Neutral sphingomyelinase inhibition decreases ER stress-mediated apoptosis and inducible nitric oxide synthase in retinal pigment epithelial cells.Q39003216
Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle.Q39090640
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagyQ39283168
Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCalpha joins the frayQ39898116
A role for ceramide in driving cancer cell resistance to doxorubicin.Q40017408
Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomesQ40158216
Sphingosine kinase type 2 activation by ERK-mediated phosphorylationQ40168870
Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspasesQ40181636
Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transportQ40234029
Different effects of long- and short-chain ceramides on the gel-fluid and lamellar-hexagonal transitions of phospholipids: a calorimetric, NMR, and x-ray diffraction studyQ40329174
Evidence for mitochondrial localization of a novel human sialidase (NEU4).Q40431576
Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation.Q40437372
Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.Q40496768
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.Q40498233
Exogenous ganglioside GD1a enhances epidermal growth factor receptor binding and dimerizationQ40542023
Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cellsQ40607620
Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosisQ40611451
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosisQ40649042
Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.Q40735901
Role of ceramide during cisplatin-induced apoptosis in C6 glioma cellsQ40792857
Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosisQ40806056
Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cellsQ40841732
Ablation of ceramide synthase 2 strongly affects biophysical properties of membranesQ35747763
Targeting sphingosine-1-phosphate in hematologic malignanciesQ36011176
Modulation of ceramide synthase activity via dimerizationQ36033185
Structural and functional features and significance of the physical linkage between ER and mitochondria.Q36118657
Mitochondrial ceramide and the induction of apoptosisQ36259131
Ceramide-enriched membrane domainsQ36286893
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosisQ36422392
Dissecting p53-dependent apoptosis.Q36423933
Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramideQ36443622
Gangliosides as components of lipid membrane domains.Q36597110
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chainQ36620822
Acid ceramidase and human diseaseQ36634467
Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cellsQ36651556
CERT and intracellular trafficking of ceramideQ36741724
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.Q36798604
BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteinsQ36813008
Do mitochondria act as "cargo boats" in the journey of GD3 to the nucleus during apoptosis?Q36896277
Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosisQ36913748
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathwaysQ33552843
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.Q33676598
The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Q33782414
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathwaysQ33796283
Sphingosine kinase 1 in cancerQ33853998
Sphingolipids in obesity, type 2 diabetes, and metabolic diseaseQ33880588
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiationQ33939529
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenarioQ33995987
The Second Thudichum Lecture. Cerebral isolates and neurochemical discoveryQ34067416
Enlargement and contracture of C2-ceramide channelsQ34182656
Loss of ceramide synthase 3 causes lethal skin barrier disruptionQ34228817
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemiaQ34360352
Ceramide and the mitochondrial respiratory chain.Q34363131
Ceramide in apoptosis signaling: relationship with oxidative stressQ34369834
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolismQ34395114
Subcellular localization of human neutral ceramidase expressed in HEK293 cellsQ34413039
Bcl2L13 is a ceramide synthase inhibitor in glioblastomaQ34413943
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondriaQ34453596
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respirationQ34502695
Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolismQ34504957
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteinsQ34559507
p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiationQ34636385
Visualization of ceramide channels by transmission electron microscopyQ34709260
Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse modelsQ34729966
Mitochondria and ceramide: intertwined roles in regulation of apoptosisQ34747143
Sphingosine kinase localization in the control of sphingolipid metabolismQ34810283
Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2Q34891145
Sphingosine, a product of ceramide hydrolysis, influences the formation of ceramide channels.Q34984615
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.Q35107592
Sphingosine kinase 1 and cancer: a systematic review and meta-analysisQ35108994
Nonredundant role of Bax and Bak in Bid-mediated apoptosisQ35150716
Raft ceramide in molecular medicineQ35559152
The BCL-2 family reunionQ35568029
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane networkQ35605031
Ceramide as an activator lipid of cathepsin D.Q40874792
Mass spectrometric identification of increased C16 ceramide levels during apoptosisQ40922788
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysisQ41065043
Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL.Q41116327
1alpha,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alphaQ41116797
Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA.Q41135340
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cellsQ41995354
Role of sphingosine kinase localization in sphingolipid signalingQ42283814
Ceramide synthase 1 is regulated by proteasomal mediated turnoverQ42452797
Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalitiesQ42622589
Ceramide induces apoptosis via caspase-dependent and caspase-independent pathways in mesenchymal stem cells derived from human adipose tissueQ42755582
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosisQ42799996
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?Q42806473
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesiclesQ42825650
Enhancement of epidermal growth factor signaling and activation of SRC kinase by gangliosidesQ42825899
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.Q42828937
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegansQ42936816
Sphingosine kinase: a closer look at lastQ42957279
Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.Q43045816
Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membraneQ43184244
Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectivelyQ43268398
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptorsQ43268410
Bax distribution into mitochondrial detergent-resistant microdomains is related to ceramide and cholesterol content in postischemic heartsQ43289014
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthaseQ43559533
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondriaQ43559569
Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosisQ43592446
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late eventQ43613062
Taxol-induced ceramide generation and apoptosis in human breast cancer cellsQ43629751
Molecular mechanisms of ceramide-mediated CD95 clusteringQ43642943
Bax-dependent apoptosis induced by ceramide in HL-60 cellsQ43744119
Ceramide does not act as a general second messenger for ultraviolet-induced apoptosisQ43854600
Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells.Q44122246
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathwayQ44400926
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesisQ44572814
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcriptionQ44687763
Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activityQ44755093
Fabry disease: reduced activities of respiratory chain enzymes with decreased levels of energy-rich phosphates in fibroblastsQ44863203
Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.Q44985683
Cytoplasmic p53: bax and forward.Q45960099
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieuQ46673506
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopeciaQ46719704
Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins.Q46855408
Ceramide and its transport protein (CERT) contribute to deterioration of mitochondrial structure and function in aging oocytesQ46885982
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesizedQ47888807
A Note on the Life of J. L. W. Thudichum (1829–1901)Q48490374
Sphingomyelin-enriched microdomains define the efficiency of native Ca(2+)-triggered membrane fusionQ48508151
The first Thudichum lecture, 15 January 1974: Biochemical specificity in neuromal functionQ48556733
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.Q52547440
Association of fission proteins with mitochondrial raft-like domains.Q52598062
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.Q53364131
Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.Q53380872
Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells.Q53513146
Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities.Q54097739
P433issue2
P921main subjectapoptotic processQ14599311
sphingolipidsQ410395
P304page(s)153-168
P577publication date2015-01-27
P1433published inJournal of Bioenergetics and BiomembranesQ5044470
P1476titleSphingolipids and mitochondrial apoptosis
P478volume48

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