Mitochondrial dynamics and cell death in heart failure

scientific article published on 12 February 2016

Mitochondrial dynamics and cell death in heart failure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10741-016-9530-2
P698PubMed publication ID26872674

P2093author name stringJosé Marín-García
Alexander T Akhmedov
P2860cites workPINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cellsQ24291591
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cellsQ24293452
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
MiD49 and MiD51, new components of the mitochondrial fission machineryQ24300113
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationQ24300125
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyQ24300975
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathwaysQ24302411
The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cellsQ24306289
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fissionQ24307570
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1Q24308767
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cellsQ24312865
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cellsQ24315625
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagyQ24318282
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondriaQ24320227
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fissionQ24336802
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosisQ24338169
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyQ24339224
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.Q24529124
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosisQ24562044
Fission and selective fusion govern mitochondrial segregation and elimination by autophagyQ24652230
A human dynamin-related protein controls the distribution of mitochondriaQ24682958
Mitochondrial dynamics in cardiovascular health and diseaseQ26820835
Mitochondrial dynamism and heart disease: changing shape and shaping changeQ26825299
Recent advances into the understanding of mitochondrial fissionQ26829588
Mitochondrial form and functionQ26866448
New insights into the function and regulation of mitochondrial fissionQ27010550
Mechanisms of mitophagyQ27310261
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundleQ27642557
Structural basis for recruitment of mitochondrial fission complexes by Fis1Q27649021
The Mitochondrial Fission Receptor MiD51 Requires ADP as a CofactorQ27681635
Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusionQ27930869
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.Q27931656
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1pQ27933279
UGO1 encodes an outer membrane protein required for mitochondrial fusionQ27937632
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyQ28140286
hFis1, a novel component of the mammalian mitochondrial fission machineryQ28208369
Mutation spectrum and splicing variants in the OPA1 geneQ28216607
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2Q28221207
Mitochondrial dynamics in pulmonary arterial hypertensionQ35116543
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.Q35165455
Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusinQ35359238
Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytesQ35543486
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cellsQ35596393
Mitochondrial fusion is essential for organelle function and cardiac homeostasisQ35613447
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cellsQ35754670
Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell deathQ35906435
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in miceQ36014531
Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytesQ36078791
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.Q36119045
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavageQ36119051
Mitochondrial fission in apoptosisQ36198122
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytesQ36215833
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heartQ36455449
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.Q36477755
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Which came first, the cytochrome c release or the mitochondrial fission?Q36501201
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instabilityQ36522684
Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarctionQ36526385
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphologyQ36817918
Calcium cycling and signaling in cardiac myocytes.Q36995547
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell deathQ37036070
Positioning mitochondrial plasticity within cellular signaling cascades.Q37241342
Mitochondrial OPA1, apoptosis, and heart failureQ37341059
Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.Q37393582
MitophagyQ37415668
Dynamic organization of mitochondria in human heart and in myocardial diseaseQ37484759
Regulation of mitofusin-2 expression in skeletal muscleQ37486046
Mitochondrial dynamics in mammalian health and diseaseQ37543838
Mitophagy and Parkinson's disease: the PINK1-parkin link.Q37587126
Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease.Q37686255
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1Q37774674
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusionQ28251846
Mitochondrial fusion and fission in cell life and deathQ28299119
Mitochondrial dynamics--mitochondrial fission and fusion in human diseasesQ28303322
Mitochondria in heart failureQ28385915
Mitophagy and heart failureQ28388167
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelingQ28506506
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathyQ28509163
Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase FzoQ28568194
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1Q28571639
PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertensionQ28578858
Mitochondrial fission controls DNA fragmentation by regulating endonuclease GQ28582850
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondriaQ28592217
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1Q28594164
SLP-2 is required for stress-induced mitochondrial hyperfusionQ28594182
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentQ28594513
Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating proteinQ28854275
Mitochondria: in sickness and in healthQ29614825
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusinQ29615625
The PINK1/Parkin pathway regulates mitochondrial morphologyQ29615641
Mitochondrial fission, fusion, and stressQ29616536
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosisQ29616568
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.Q29616569
Mitochondrial dynamics and apoptosisQ29616570
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in miceQ29617092
Mitofusin 2 tethers endoplasmic reticulum to mitochondriaQ29619861
C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membraneQ29620388
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell deathQ29620448
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell deathQ30480587
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusionQ30489225
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytesQ30499251
RALA and RALBP1 regulate mitochondrial fission at mitosisQ30503960
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertensionQ30531765
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNAQ33370933
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathwayQ33552320
Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusionQ33757936
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblastsQ33847524
Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).Q33916484
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathyQ33927271
Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathyQ33931661
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial primingQ34107322
Mitochondrial morphology and cardiovascular diseaseQ34113390
Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factorsQ34121511
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial divisionQ34186619
Cardiac mitochondria and arrhythmiasQ34307966
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivoQ34489899
Molecular machinery of mitochondrial fusion and fissionQ34589785
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuliQ34605764
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brainQ34806899
The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensembleQ34807191
Autophagy protects the proximal tubule from degeneration and acute ischemic injury.Q34870792
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart functionQ35035191
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblastsQ35054529
Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytesQ35057168
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvationQ35064216
Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and functionQ35112429
Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart diseaseQ37777273
Bioenergetics of the failing heartQ37792507
Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fissionQ37833279
Dynamin: functional design of a membrane fission catalyst.Q37877698
Quality control of mitochondrial proteostasisQ37882863
What genetics tells us about the causes and mechanisms of Parkinson's diseaseQ37947563
Mitochondrial morphology in mitophagy and macroautophagyQ37992366
Mitochondrial dynamics in heart diseaseQ37997232
Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammalsQ38032613
SR and mitochondria: calcium cross-talk between kissing cousinsQ38035635
Mitochondria, myocardial remodeling, and cardiovascular disease.Q38042865
Mitochondrial dynamics in neurodegenerationQ38060435
Mitochondrial dynamism and cardiac fate--a personal perspectiveQ38101408
Mitochondrial fusion proteins and human diseases.Q38115530
The regulation of mitochondrial dynamicsQ38205658
PINK1/Parkin-mediated mitophagy in mammalian cellsQ38362214
Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Q39536018
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injuryQ39710554
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphologyQ40227379
Structural basis of mitochondrial tethering by mitofusin complexes.Q40527845
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensationQ41764115
Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart developmentQ41888127
Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalkQ42325904
Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stressQ42486562
How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Q42943868
Riociguat for pulmonary hypertension--a glass half fullQ43728967
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathyQ44020107
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heartQ45733826
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarizationQ46477108
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell deathQ46839351
Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potentialQ46853142
Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.Q51313895
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Q53548157
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.Q53628380
Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1Q56547173
Transport of Ca2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytesQ77426278
Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosisQ80809799
Heart failure in Parkinson's disease: analysis of the United States medicare current beneficiary surveyQ80822259
Physiological growth synergizes with pathological genes in experimental cardiomyopathyQ80992476
Macroautophagy in homeostasis of pancreatic beta-cellQ82884871
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1Q83034995
Inhibition of autophagy in the heart induces age-related cardiomyopathyQ84134805
Not just the powerhouse of the cell: emerging roles for mitochondria in the heartQ84665416
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signalingQ86444982
P433issue2
P921main subjectheart failureQ181754
cell deathQ2383867
P304page(s)123-136
P577publication date2016-02-12
P1433published inHeart Failure ReviewsQ2167497
P1476titleMitochondrial dynamics and cell death in heart failure
P478volume21

Reverse relations

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