Characterization of a multicomponent live, attenuated Shigella flexneri vaccine

scientific article published on 21 April 2016

Characterization of a multicomponent live, attenuated Shigella flexneri vaccine is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/FEMSPD/FTW034
P932PMC publication ID5985478
P698PubMed publication ID27106253

P50authorMyron M. LevineQ29564379
Marcela F. PasettiQ56380831
P2093author name stringTao Wu
Eileen M Barry
Avital Shimanovich
BreOnna C DeLaine
Christen L Grassel
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Virulent Shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophagesQ33556806
Mortality due to shigellosis: community and hospital dataQ33579264
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry.Q33613340
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Predominance of serotype-specific mucosal antibody response in Shigella flexneri-infected humans living in an area of endemicityQ34008763
Shigella isolates from the global enteric multicenter study inform vaccine developmentQ34202171
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Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccineQ34545910
Global etiology of travelers' diarrhea: systematic review from 1973 to the present.Q34606236
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.Q35091245
Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccineQ35510455
Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosisQ35545918
Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunitQ35598035
Shigella flexneri infection: pathogenesis and vaccine development.Q35671854
Decreasing Shigellosis-related Deaths withoutShigellaspp.–specific Interventions, AsiaQ35804868
Shigella IpaB and IpaD displayed on L. lactis bacterium-like particles induce protective immunity in adult and infant mice.Q35946462
The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control studyQ36412034
Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard roadQ36844719
Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a.Q36920244
Progress and pitfalls in Shigella vaccine researchQ37105553
Characterization of a novel fusion protein from IpaB and IpaD of Shigella spp. and its potential as a pan-Shigella vaccine.Q37335984
Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine releaseQ37458618
Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypesQ37720658
Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.Q39146446
Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, ChileQ39252440
Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophagesQ39516481
Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosisQ40211202
Shigella flexneri induces apoptosis in infected macrophagesQ41614246
Macrophage apoptosis in microbial infections.Q41757390
Outbreaks of acute gastroenteritis transmitted by person-to-person contact--United States, 2009-2010.Q42282923
Cross-reactivity of Shigella flexneri serotype 2a O antigen antibodies following immunization or infectionQ44713046
IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis.Q51189374
Characterization of GRO alpha, beta and gamma expression in human colonic tumours: potential significance of cytokine involvementQ67510954
Protective efficacy of oral immunization with heat-killed Shigella flexneri 2a in animal model: study of cross protection, immune response and antigenic recognitionQ73507076
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammationQ73867640
Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cellsQ73948765
Experimental shigella keratoconjunctivitis; a preliminary reportQ78714396
P433issue5
P921main subjectShigella flexneriQ1644417
attenuated vaccineQ1810913
P577publication date2016-04-21
P1433published inPathogens and diseaseQ27724629
P1476titleCharacterization of a multicomponent live, attenuated Shigella flexneri vaccine
P478volume74

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cites work (P2860)
Q47657350Editorial: Infection and immunity research at the University of Maryland, Baltimore
Q64270378Genome Analysis of Shigella flexneri Serotype 3b Strain SFL1520 Reveals Significant Horizontal Gene Acquisitions Including a Multidrug Resistance Cassette
Q37477191Shigella Vaccine Development: Finding the Path of Least Resistance

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