Poring over two-pore channel pore mutants

scientific article published on June 2015

Poring over two-pore channel pore mutants is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1166/MSR.2015.1044
P932PMC publication ID4876920
P698PubMed publication ID27226934

P2093author name stringSandip Patel
Christopher J Penny
P2860cites workThe Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
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TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Q24621022
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Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic ChannelsQ27680241
Two alternative conformations of a voltage-gated sodium channelQ27685182
Two-pore channels at the intersection of endolysosomal membrane trafficQ28085768
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cellsQ28138792
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggsQ28216586
High susceptibility to fatty liver disease in two-pore channel 2-deficient miceQ28246421
Domain assembly of NAADP-gated two-pore channelsQ28250269
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsQ28260464
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1Q28264441
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesQ28276964
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An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signalsQ28294394
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The voltage-gated sodium channel TPC1 confers endolysosomal excitability.Q30810815
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal traffickingQ33816664
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The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationQ34583526
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Q34685254
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channelsQ35067713
Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Q35082699
NAADP on targetQ37997679
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cellsQ38275522
Coupling acidic organelles with the ER through Ca²⁺ microdomains at membrane contact sites.Q38417593
Questioning regulation of two-pore channels by NAADPQ39515801
Outer pore architecture of a Ca2+-selective TRP channelQ40596874
Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptorQ41603790
Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Q41820235
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytesQ41891896
Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signalsQ42959504
pH-dependent regulation of lysosomal calcium in macrophagesQ43893449
A computational model of lysosome-ER Ca2+ microdomains.Q50672345
The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.Q50746326
Calcium signaling: NAADP ascends as a new messengerQ73086519
Acidic Ca(2+) stores come to the foreQ83879499
Role of TRPML and two-pore channels in endolysosomal cation homeostasisQ83938128
Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraintsQ84209506
P433issue1
P304page(s)46-52
P577publication date2015-06-01
P1433published inMessenger (Los Angeles, Calif. : Print)Q27724829
P1476titlePoring over two-pore channel pore mutants
P478volume4