Upregulation of GRIM-19 inhibits the growth and invasion of human breast cancer cells

scientific article published on 7 May 2015

Upregulation of GRIM-19 inhibits the growth and invasion of human breast cancer cells is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.3892/MMR.2015.3757
P698PubMed publication ID25955394

P2093author name stringWei Zhang
Wei Geng
Tong Jiang
Duo Zhang
Ye Du
Jiuli Yuan
P2860cites workDownregulation of GRIM-19 promotes growth and migration of human glioma cellsQ46297561
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasisQ47677996
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.Q53594823
Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa BQ64381924
High level of urokinase-type plasminogen activator is a new prognostic marker in patients with gastric carcinomaQ73090918
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasisQ78836958
Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3Q80579943
Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinomaQ83856045
Expression and clinical significance of GRIM-19 in lung cancerQ84098585
Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approachQ22254731
Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell deathQ24296337
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3Q24309232
GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interactionQ24553130
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex IQ24561759
Cancer statistics, 2013Q27860762
GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)Q28214434
STATs and gene regulationQ29547796
Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancersQ34334192
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.Q36615843
Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesisQ36685267
Analysis of patients with false negative mammography and symptomatic breast carcinomaQ36967893
Breast cancer statistics, 2013.Q38151550
MicroRNA-21 in breast cancer: diagnostic and prognostic potentialQ38163908
Breast cancer stem cells and the immune system: promotion, evasion and therapy.Q38226597
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
Plasmid-based Stat3-specific siRNA and GRIM-19 inhibit the growth of thyroid cancer cells in vitro and in vivoQ38988178
GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiationQ39249873
Depletion of GRIM-19 accelerates hepatocellular carcinoma invasion via inducing EMT and loss of contact inhibitionQ39439169
Gene associated with retinoid-interferon-induced mortality-19 suppresses growth of lung adenocarcinoma tumor in vitro and in vivoQ39637333
Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell lineQ39703120
Effects of plasmid-based Stat3-specific short hairpin RNA and GRIM-19 on PC-3M tumor cell growthQ40020168
A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomasQ40274291
Point mutation in GRIM-19: a new genetic lesion in Hurthle cell thyroid carcinomasQ43200914
Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomasQ44262671
P433issue2
P304page(s)2919-2925
P577publication date2015-05-07
P1433published inMolecular Medicine ReportsQ26842180
P1476titleUpregulation of GRIM-19 inhibits the growth and invasion of human breast cancer cells
P478volume12

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cites work (P2860)
Q38828603Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo
Q47807687Antitumor activity of iNGR-GRIM-19 in colorectal cancer
Q50863877GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription.
Q47778579GRIM-19 represses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling
Q90046633Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization
Q47279510Prognostic value of GRIM-19, NF-κB and IKK2 in patients with high-grade serous ovarian cancer
Q47202515Retinoid interferon-induced mortality19 (GRIM19) inhibits proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes

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