Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo

scientific article published on 30 September 2015

Additive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.3892/MMR.2015.4393
P698PubMed publication ID26458553

P2093author name stringWei Zhang
Ying Shao
Wei Geng
Tong Jiang
Haipeng Liu
Duo Zhang
Ye Du
P2860cites workSynergistic effects of eukaryotic coexpression plasmid carrying LKB1 and FUS1 genes on lung cancer in vitro and in vivoQ45863481
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancerQ46712872
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.Q53594823
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndromeQ57240072
Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approachQ22254731
Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell deathQ24296337
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex IQ24561759
Matrix metalloproteinases and cancer - roles in threat and therapyQ27027389
Cancer statistics, 2013Q27860762
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)Q28214434
The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cellsQ33783277
Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathwaysQ34602408
LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathwayQ34825535
Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesisQ36685267
Analysis of patients with false negative mammography and symptomatic breast carcinomaQ36967893
Targeted therapy in triple-negative metastatic breast cancer: a systematic review and meta-analysisQ37477489
Plasmid-based E6-specific siRNA and co-expression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivoQ37478104
Targeting LKB1 signaling in cancer.Q38071485
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targetsQ38107451
Breast cancer statistics, 2013.Q38151550
MicroRNAs in the Regulation of MMPs and MetastasisQ38199556
Upregulation of GRIM-19 inhibits the growth and invasion of human breast cancer cellsQ38877630
Plasmid-based Stat3-specific siRNA and GRIM-19 inhibit the growth of thyroid cancer cells in vitro and in vivoQ38988178
Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivoQ39209841
Depletion of GRIM-19 accelerates hepatocellular carcinoma invasion via inducing EMT and loss of contact inhibitionQ39439169
Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell lineQ39703120
Effects of plasmid-based Stat3-specific short hairpin RNA and GRIM-19 on PC-3M tumor cell growthQ40020168
Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potentialQ40206610
Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomasQ44262671
Synergistic effects of co-expression plasmid‑based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivoQ44973273
P433issue5
P304page(s)7665-7672
P577publication date2015-09-30
P1433published inMolecular Medicine ReportsQ26842180
P1476titleAdditive effects of eukaryotic co‑expression plasmid carrying GRIM‑19 and LKB1 genes on breast cancer in vitro and in vivo
P478volume12

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