Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.

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Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp. is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.591610
P932PMC publication ID4335252
P698PubMed publication ID25564612

P50authorMariko NaitoQ114019319
P2093author name stringKoji Nakayama
Naoya Ohara
Masaaki Nakayama
Tetsuyoshi Inoue
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
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Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairmentQ24645315
AKT/PKB signaling: navigating downstreamQ24657857
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceQ27650096
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptorQ27933845
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343Q28213632
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
mTOR signaling at a glanceQ29619857
Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipidsQ34023096
Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in ratsQ34290681
The activation of Akt/PKB signaling pathway and cell survival.Q34405519
Protein kinase B/Akt at a glanceQ34474692
Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signallingQ34521878
Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalisQ34758757
Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells.Q53372561
Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagAQ77863752
Regulation of Akt signaling activation by ubiquitinationQ34799443
Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pyloriQ35792563
Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblastsQ36211069
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervationQ36526251
Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxinsQ36536668
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migrationQ36548024
A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cellsQ36849618
Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathwayQ37041573
Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriaeQ37200512
Potential role of periodontal infection in respiratory diseases - a reviewQ37206164
The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalisQ37470595
The PKB/AKT pathway in cancerQ37705534
Diabetes mellitus and periodontitis: a tale of two common interrelated diseasesQ37895120
Regulation of TFEB and V-ATPases by mTORC1.Q38256715
Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responsesQ39076689
Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathwaysQ39078386
Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway.Q39117983
Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasionQ39146591
Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid raftsQ39266491
Schisandra chinensis α-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophagesQ39490588
Cdc42 and the phosphatidylinositol 3-kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cellsQ39846450
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutationQ40561467
YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathwayQ40715506
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membraneQ40775082
A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systemsQ40997028
Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cellsQ41577708
Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responsesQ41807835
Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin SynthesisQ41890667
Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiencyQ41982299
Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinaseQ42137745
Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathwayQ42452879
Luteolin and fisetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in human gingival fibroblastsQ42513998
Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartmentsQ42561312
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.Q43247716
Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection.Q43825369
Porphyromonas gingivalis-induced autophagy suppresses cell proliferation through G1 arrest in oral cancer cellsQ44003842
Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt.Q44354916
Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharideQ44504190
Regulation of ICAM-1 expression in gingival fibroblasts infected with high-glucose-treated P. gingivalisQ44769828
Calcineurin mediates AKT dephosphorylation in the ischemic rat retinaQ46429789
Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesiclesQ46664579
Porphyromonas gingivalis-induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinaseQ46854879
Involvement of phosphatidylinositol 3-Kinase/Akt signaling pathway in β1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells.Q50878508
Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence.Q52508036
Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis.Q53182154
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectPorphyromonas gingivalisQ3214147
P304page(s)5190-5202
P577publication date2015-01-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleAttenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.
P478volume290

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cites work (P2860)
Q40675549Apple- and Hop-Polyphenols Inhibit Porphyromonas gingivalis-Mediated Precursor of Matrix Metalloproteinase-9 Activation and Invasion of Oral Squamous Cell Carcinoma Cells
Q91599118Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model
Q98465704Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
Q37307064Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFα Responses
Q47334710Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal diseases
Q35833765Noncanonical activation of β-catenin by Porphyromonas gingivalis
Q47100096Oral microbiome and peri-implant diseases: where are we now?
Q92408958Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors
Q40118000Porphyromonas gingivalis suppresses invasion of Fusobacterium nucleatum into gingival epithelial cells.
Q89981441Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection
Q26741196Role of Porphyromonas gingivalis HmuY in Immunopathogenesis of Chronic Periodontitis
Q40871360Role of mitogen-activated protein kinase pathways in migration of gingival epithelial cells in response to stimulation by cigarette smoke condensate and infection by Porphyromonas gingivalis
Q47104397Single-Cell Phosphospecific Flow Cytometric Analysis of Canine and Murine Adipose-Derived Stem Cells

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