Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways

scientific article published on 14 October 2013

Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways is …
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scholarly articleQ13442814

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P356DOI10.1128/IAI.01140-12
P8608Fatcat IDrelease_a7lpfl3vbjgctpe6bg4r4mkgvu
P932PMC publication ID3911866
P698PubMed publication ID24126532
P5875ResearchGate publication ID257813910

P50authorMariko NaitoQ114019319
P2093author name stringYuki Fujita
Koji Nakayama
Naoya Ohara
Seiji Iida
Masaaki Nakayama
Eiki Yamachika
Tetsuyoshi Inoue
P2860cites workUse of T7 RNA polymerase to direct expression of cloned genesQ27860692
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Inflammatory cytokines are suppressed by light-emitting diode irradiation of P. gingivalis LPS-treated human gingival fibroblasts: inflammatory cytokine changes by LED irradiationQ33981615
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Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activationQ34120648
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The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophagesQ34601780
Multiple control of interleukin-8 gene expressionQ34648084
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The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipainQ35397754
The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats.Q35522174
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Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activationQ36115724
Porphyromonas gingivalis RgpA-Kgp proteinase-adhesin complexes penetrate gingival tissue and induce proinflammatory cytokines or apoptosis in a concentration-dependent mannerQ37099426
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Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells.Q39292564
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Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis.Q39570767
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Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cellsQ39653552
Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cellsQ39654974
Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2.Q39700947
MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cellsQ39808548
Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism.Q39915461
Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS.Q39949183
Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast culturesQ40152310
HtpG, the Porphyromonas gingivalis HSP-90 homologue, induces the chemokine CXCL8 in human monocytic and microvascular vein endothelial cellsQ40161806
Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reductionQ40332613
Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages.Q40714259
Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directionsQ40891575
IL-8 degradation by Porphyromonas gingivalis proteasesQ40957694
Periodontal diseases: diagnosisQ41444872
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Serum antibodies against the hemoglobin-binding domain (HA2) of Porphyromonas gingivalisQ44944224
Autolysis of Porphyromonas gingivalis is accompanied by an increase in several periodontal pathogenic factors in the supernatantQ44991883
MAP kinases: charting the regulatory pathwaysQ45270866
Cytokine expression in periodontal health and diseaseQ45297941
Arginine-specific gingipain A from Porphyromonas gingivalis induces Weibel-Palade body exocytosis and enhanced activation of vascular endothelial cells through protease-activated receptorsQ46969076
Activation of transcription factors and IL-8 expression in neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalisQ48033558
Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells.Q50131462
Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence.Q52508036
Role of p38 mitogen-activated protein kinase pathway in Porphyromonas gingivalis lipopolysaccharide-induced VCAM-1 expression in human aortic endothelial cells.Q54336729
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Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitisQ70827185
Localization of interleukin-8 in human gingival tissuesQ70990051
Differential expression of IL-1 beta, TNF-alpha, IL-6, and IL-8 in human monocytes in response to lipopolysaccharides from different microbesQ72316266
Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatmentQ73152786
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitisQ74067568
Haemoglobin receptor protein is intragenically encoded by the cysteine proteinase-encoding genes and the haemagglutinin-encoding gene of Porphyromonas gingivalisQ74183899
Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitisQ77296117
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal diseaseQ77746244
Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagAQ77863752
Prevalence of Porphyromonas gingivalis in relation to periodontal status assessed by real-time PCRQ80488589
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
Porphyromonas gingivalisQ3214147
P304page(s)202-211
P577publication date2013-10-14
P1433published inInfection and ImmunityQ6029193
P1476titleHemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways
P478volume82

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cites work (P2860)
Q38922535Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.
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Q38497234Chemokine function in periodontal disease and oral cavity cancer
Q47334710Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal diseases
Q64265564Oral Mucosal Epithelial Cells
Q26741196Role of Porphyromonas gingivalis HmuY in Immunopathogenesis of Chronic Periodontitis
Q38708108Salmeterol, a Long-Acting β2-Adrenergic Receptor Agonist, Inhibits Macrophage Activation by Lipopolysaccharide From Porphyromonas gingivalis
Q90199539Who is who in oral cancer?

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