Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

scientific article published on 11 January 2017

Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C6FO01475E
P698PubMed publication ID28074953

P50authorNorma Julieta Salazar-LópezQ47158653
Jesús A Domínguez-AvilaQ85217856
Gustavo R Velderrain-RodríguezQ88121853
P2093author name stringC-Y Oliver Chen
Gustavo A González-Aguilar
Abraham Wall-Medrano
Maribel Robles-Sánchez
P2860cites workPredicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsQ26764739
Bioavailability of bioactive food compounds: a challenging journey to bioefficacyQ26853534
Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial propertiesQ27001250
Flavonoid bioavailability and attempts for bioavailability enhancementQ27009155
Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review.Q27692081
Dietary polyphenols in prevention and treatment of prostate cancerQ28084787
Acteoside: a lipase inhibitor from the Chinese tea Ligustrum purpurascens kudingchaQ45820099
Maté tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice.Q45960069
Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption.Q46001685
Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro modelsQ46063158
Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats.Q46197858
Binding sites of resveratrol, genistein, and curcumin with milk α- and β-caseinsQ46311643
Intestinal uptake of MPP+ is differently affected by red and white wineQ46373242
Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayersQ46398716
The effect of milk alpha-casein on the antioxidant activity of tea polyphenolsQ46430751
Dietary fat increases quercetin bioavailability in overweight adultsQ46562405
Cholesterol induces surface localization of polyphenols in model membranes thus enhancing vesicle stability against lysozyme, but reduces protection of distant double bonds from reactive-oxygen speciesQ46566165
Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.Q46583886
Non-covalent interaction between procyanidins and apple cell wall material. Part III: Study on model polysaccharidesQ46604032
Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomesQ46677607
Mechanism of inhibition of rice bran lipase by polyphenols: a case study with chlorogenic acid and caffeic acidQ46905818
Non-covalent binding of proteins to polyphenols correlates with their amino acid sequenceQ47672003
Effect on in vitro starch digestibility of Mexican blue maize anthocyaninsQ47869375
Inhibitory effect of black tea and its combination with acarbose on small intestinal α-glucosidase activityQ47962797
Fast identification of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC-MS/MS.Q47966417
Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cellsQ48024063
Characterization and bioavailability of tea polyphenol nanoliposome prepared by combining an ethanol injection method with dynamic high-pressure microfluidizationQ50003167
Impact of the Fenton process in meat digestion as assessed using an in vitro gastro-intestinal modelQ50240377
Protection against oxidative damage in human erythrocytes and preliminary photosafety assessment of Punica granatum seed oil nanoemulsions entrapping polyphenol-rich ethyl acetate fractionQ50436580
Models based on ultraviolet spectroscopy, polyphenols, oligosaccharides and polysaccharides for prediction of wine astringencyQ50439467
Influence of polyphenols from lingonberry, cranberry, and red grape on in vitro digestibility of riceQ50444607
Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environmentQ50450585
Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activityQ28263349
Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and GlucoseQ28578597
Bioavailability of ferulic acid is determined by its bioaccessibilityQ29545005
Bioavailability and delivery of nutraceuticals using nanotechnologyQ33584133
Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).Q33811166
Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: a study on the Spanish dietQ34120281
Natural inhibitors of pancreatic lipase as new players in obesity treatment.Q34171234
Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemiaQ34285688
Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion techniqueQ34358182
Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatmentQ34443537
Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteersQ34581718
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.Q34591663
Genetic variation in HTR4 and lung function: GWAS follow-up in mouseQ34847876
Theaflavins from black tea, especially theaflavin-3-gallate, reduce the incorporation of cholesterol into mixed micellesQ34892488
Effect of bioactive dietary polyphenols on zinc transport across the intestinal Caco-2 cell monolayersQ34925122
Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cellsQ35013544
SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcuminQ35087116
Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats.Q35173623
Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materialsQ35196019
The small intestine as a xenobiotic-metabolizing organQ35587731
Investigate the binding of catechins to trypsin using docking and molecular dynamics simulationQ35621574
Comparative inhibitory potential of selected dietary bioactive polyphenols, phytosterols on CYP3A4 and CYP2D6 with fluorometric high-throughput screening.Q35801869
Effect of grapefruit juice on the bioactivation of prasugrelQ35846138
Characteristics of Gouda cheese supplemented with fruit liquorsQ35966492
Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanismsQ36765130
Alterations in the intestinal assimilation of oxidized PUFAs are ameliorated by a polyphenol-rich grape seed extract in an in vitro model and Caco-2 cellsQ37017906
In vivo pharmacokinetic comparisons of ferulic acid and puerarin after oral administration of monomer, medicinal substance aqueous extract and Nao-De-Sheng to ratsQ37202437
Intestinal lipid absorptionQ37216738
Impact of nanotechnology on drug delivery.Q37389440
Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese miceQ37479582
Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicalsQ37646827
Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactionsQ37704154
Effect of polyphenols on the intestinal and placental transport of some bioactive compounds.Q37731000
Dietary fiber as a carrier of dietary antioxidants: an essential physiological functionQ37818118
Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expressionQ40395447
Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug-Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 SubstratesQ40867612
Interaction mechanism between green tea extract and human α-amylase for reducing starch digestionQ40937485
Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4).Q41772736
Transport and metabolism of ferulic acid through the colonic epitheliumQ42520594
Black-Tea Polyphenols Decrease Micellar Solubility of Cholesterol in Vitro and Intestinal Absorption of Cholesterol in RatsQ42948234
A survey of modulation of gut microbiota by dietary polyphenols.Q43179351
Quercetin and naringenin transport across human intestinal Caco-2 cells.Q43244903
A comparison of pectin, polyphenols, and phytosterols, alone or in combination, to lovastatin for reduction of serum lipids in familial hypercholesterolemic swineQ43280046
Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in ratsQ43282589
Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjectsQ43571907
Pharmacokinetics and bioavailability of quercetin glycosides in humansQ43613477
Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in ratsQ43905866
Polyphenol-induced inhibition of the response of na(+)/glucose cotransporter expressed in Xenopus oocytesQ44109701
Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestineQ44220876
Intestinal absorption of p-coumaric and gallic acids in rats after oral administrationQ44868123
Interaction between amylose and tea polyphenols modulates the postprandial glycemic response to high-amylose maize starchQ44887016
Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunumQ44925379
Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model.Q45078300
Evidence for alpha-tocopherol regeneration reaction of green tea polyphenols in SDS micellesQ45181133
The fortification of tea with sweeteners and milk and its effect on in vitro antioxidant potential of tea product and glutathione levels in an animal modelQ45344921
Binding affinity between dietary polyphenols and β-lactoglobulin negatively correlates with the protein susceptibility to digestion and total antioxidant activity of complexes formedQ45372721
Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivoQ45800036
Delivery of green tea catechin and epigallocatechin gallate in liposomes incorporated into low-fat hard cheeseQ50459425
Combined effects of green tea extracts, green tea polyphenols or epigallocatechin gallate with acarbose on inhibition against α-amylase and α-glucosidase in vitro.Q50472593
The glycemic index of pigmented potatoes is related to their polyphenol content.Q50478316
Relationship between skin cell wall composition and anthocyanin extractability of Vitis vinifera L. cv. Tempranillo at different grape ripeness degree.Q50484066
The interaction between tea polyphenols and rice starch during gelatinization.Q50520982
Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity.Q51216824
Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet-drug interaction study.Q51296585
Definition of postprandial lipaemia.Q51379483
Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery.Q52148908
Peanut-skin polyphenols, procyanidin A1 and epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin, exert cholesterol micelle-degrading activity in vitro.Q52836976
Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells.Q53336540
Transepithelial transport of phenolic acids in Flos Lonicerae Japonicae in intestinal Caco-2 cell monolayers.Q53407043
Identification and characterization of sulfonyltransferases catalyzing ethyl sulfate formation and their inhibition by polyphenols.Q53609216
The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.Q53771210
Polymeric tannins significantly alter properties and in vitro digestibility of partially gelatinized intact starch granule.Q53787931
A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration.Q53791209
Mode of pancreatic lipase inhibition activity in vitro by some flavonoids and non-flavonoid polyphenols.Q54480223
Inhibition of human α-amylase by dietary polyphenolsQ54509979
Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats.Q54590862
Upgrading of grape skins: Significance of plant cell-wall structural components and extraction techniques for phenol releaseQ56035239
Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenolsQ56964751
Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humansQ57118032
Study of the interactions between rosmarinic acid and bovine milk whey protein α-Lactalbumin, β-Lactoglobulin and LactoferrinQ57570783
Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell lineQ57703638
Evaluation of the antioxidant properties and oxidative stability of Pecorino cheese made from the raw milk of ewes fedRosmarinus officinalisL. leavesQ58046612
Gastro-pancreatic release of phenolic compounds incorporated in a polyphenols-enriched cheese-curdQ58275520
Influence of the tannin structure on the disruption effect of carbohydrates on protein–tannin aggregatesQ59211490
Role of flavonoids in intestinal tight junction regulationQ37822054
Potential biological fate of ingested nanoemulsions: influence of particle characteristics.Q37959334
Human UDP-glucuronosyltransferases: feedback loops between substrates and ligands of their transcription factorsQ38028268
Intestinal drug transporters: an overviewQ38049926
Possible effects of dietary polyphenols on sugar absorption and digestionQ38062514
A review on structure-activity relationship of dietary polyphenols inhibiting α-amylaseQ38079845
The relationship between the structure and biological actions of green tea catechinsQ38122843
PharmacokineticsQ38140365
Flavonoids as drugs at the small intestinal levelQ38149404
Phenolic compounds: their journey after intake.Q38171254
Bound phenolics in foods, a reviewQ38180269
Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolismQ38264794
Is There Consistency between the Binding Affinity and Inhibitory Potential of Natural Polyphenols as α-amylase Inhibitors?Q38369818
Dietary polyphenols against metabolic disorders: How far have we progressed in the understanding of the molecular mechanisms of action of these compounds?Q38521024
The tomato sauce making process affects the bioaccessibility and bioavailability of tomato phenolics: a pharmacokinetic studyQ38547363
Grapefruit Juice and StatinsQ38572006
Condensed catechins and their potential health-benefitsQ38589523
Adverse food-drug interactionsQ38611443
Enhancement of anticancer potential of polyphenols by covalent modificationsQ38699582
Computational modeling to predict the functions and impact of drug transporters.Q38715008
Antidiabetic effect of polyphenolic extracts from selected edible plants as α-amylase, α -glucosidase and PTP1B inhibitors, and β pancreatic cells cytoprotective agents - a comparative studyQ38862404
High-dose green tea polyphenol intake decreases CYP3A expression in a liver-specific manner with increases in blood substrate drug concentrationsQ38873643
Bioefficacy of tea catechins encapsulated in casein micelles tested on a normal mouse cell line (4D/WT) and its cancerous counterpart (D/v-src) before and after in vitro digestionQ39009689
Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cellsQ39038710
Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.Q39066251
The impact of in vitro digestion on bioaccessibility of polyphenols from potatoes and sweet potatoes and their influence on iron absorption by human intestinal cellsQ39093241
The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97.Q39308452
Effects of the antioxidant baicalein on the pharmacokinetics of nimodipine in rats: a possible role of P-glycoprotein and CYP3A4 inhibition by baicaleinQ39457484
Contribution of Musa paradisiaca in the inhibition of α-amylase, α-glucosidase and Angiotensin-I converting enzyme in streptozotocin induced rats.Q39458942
Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetinQ39547723
Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticlesQ39560005
Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention.Q39616510
Chrysoeriol and other polyphenols from Tecoma stans with lipase inhibitory activityQ39925885
Interaction between Tea Polyphenols and Bile Acid Inhibits Micellar Cholesterol SolubilityQ40228345
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
P304page(s)15-38
P577publication date2017-01-11
P1433published inFood & FunctionQ3076426
P1476titleGastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds
P478volume8

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cites work (P2860)
Q92447872Antioxidants in Extra Virgin Olive Oil and Table Olives: Connections between Agriculture and Processing for Health Choices
Q47550706Beneficial effects of consumption of acerola, cashew or guava processing by-products on intestinal health and lipid metabolism in dyslipidaemic female Wistar rats
Q36414110Bioaccessibility and bioavailability of phenolic compounds in bread: a review.
Q60800061Bioaccessibility of hydroxycinnamic acids and antioxidant capacity from sorghum bran thermally processed during simulated in vitro gastrointestinal digestion
Q90361802Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats
Q90383973Chemical Composition and In Vitro Bioaccessibility of Antioxidant Phytochemicals from Selected Edible Nuts
Q47215160Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins
Q93164216Effects of ripening on the in vitro antioxidant capacity and bioaccessibility of mango cv. 'Ataulfo' phenolics
Q88121863Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of 'Ataulfo' Mango Peel on LS180 Cells
Q50048515Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo
Q50105649Mango-bagasse functional-confectionery: vehicle for enhancing bioaccessibility and permeability of phenolic compounds.
Q64963384Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes.
Q61812595Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases

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