Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations

scientific article published on 17 January 2014

Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3324/HAEMATOL.2013.095604
P932PMC publication ID4008111
P698PubMed publication ID24441149

P50authorBob LöwenbergQ71513060
P2093author name stringPeter J M Valk
Ellen van Drunen
H Berna Beverloo
Justine K Peeters
Saman Abbas
Jasper E Koenders
Mathijs A Sanders
Remco Hoogenboezem
Annelieke Zeilemaker
Isabel W T Chu
Wendy M C Geertsma-Kleinekoort
Francois G Kavelaars
Janneke van Galen
Souad Mahamoud
Zabiollah G Abbas
P2860cites workBCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytesQ24294962
Recurring mutations found by sequencing an acute myeloid leukemia genomeQ24634204
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genomeQ24644436
DNMT3A Mutations in Acute Myeloid LeukemiaQ27559610
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemiaQ27851759
14q32 translocations are associated with mixed-lineage expression in childhood acute leukemiaQ68840106
Cytogenetics of childhood acute nonlymphocytic leukemiaQ69675957
Is t(6;14) a non-random translocation in childhood acute mixed lineage leukemia?Q71466818
Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemiasQ81369406
Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markersQ84150307
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternQ84668776
Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomasQ28508746
Bcl11a is essential for normal lymphoid developmentQ28511014
Bcl11b is required for differentiation and survival of αβ T lymphocytesQ28592191
Super-enhancers in the control of cell identity and diseaseQ28661442
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaQ29614324
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disordersQ29614510
Selective inhibition of tumor oncogenes by disruption of super-enhancersQ29617301
Mutation in TET2 in myeloid cancersQ29619292
A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.Q33182502
SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levelsQ33316565
Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulationQ33686984
t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH).Q34230063
The TLX1 oncogene drives aneuploidy in T cell transformationQ34283329
A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.Q34315758
Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL.Q34387780
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoterQ34441819
Acquired mutations in TET2 are common in myelodysplastic syndromesQ34984094
BreakDancer: an algorithm for high-resolution mapping of genomic structural variationQ34996567
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemiaQ35483684
Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic valueQ35794435
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.Q36225533
Genomic assessment of pediatric acute leukemiaQ36273597
Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturationQ36756480
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profilingQ37059396
BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytesQ37091336
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemiaQ37172988
Critical roles of Bcl11b in T-cell development and maintenance of T-cell identityQ37802423
Therapeutic advances in acute myeloid leukemiaQ37827282
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implicationsQ37827283
Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospectsQ37871413
Array-based cytogenetic approaches in acute myeloid leukemia: clinical impact and biological insightsQ37979955
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.Q47956567
Prognostically useful gene-expression profiles in acute myeloid leukemia.Q51999490
Acute mixed lineage leukemia and a t(6;14)(q25;q32) in two adults.Q53463855
BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia.Q55038892
Frequent loss of heterozygosity without loss of genetic material in acute myeloid leukemia with a normal karyotypeQ61105436
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemiaQ62927037
P433issue5
P921main subjectleukemiaQ29496
acute myeloid leukemiaQ264118
P304page(s)848-857
P577publication date2014-01-17
P1433published inHaematologicaQ5638209
P1476titleIntegrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations
P478volume99

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cites work (P2860)
Q41367937A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.
Q38692964Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.
Q33361902Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?
Q90663469Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia
Q42777609Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia.
Q34669453Kinetic analysis of BCL11B multisite phosphorylation-dephosphorylation and coupled sumoylation in primary thymocytes by multiple reaction monitoring mass spectroscopy
Q34469099Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
Q28646898Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32)
Q91812671Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia
Q88095601Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Q38686515Review: Aberrant EVI1 expression in acute myeloid leukaemia
Q26998657SWI/SNF chromatin remodeling complexes and cancer
Q89882479T(6;14)(q25;q32) involves BCL11B and is highly associated with mixed-phenotype acute leukemia, T/myeloid
Q92715615The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia
Q91723487The global clonal complexity of the murine blood system declines throughout life and after serial transplantation

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