TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis

scientific article published on March 2013

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10495-012-0782-6
P698PubMed publication ID23179179
P5875ResearchGate publication ID233769215

P2093author name stringOlivier Micheau
Alexandre Morizot
Poul H B Sorensen
Ladislav Andera
Jean-Claude Martinou
Olivier Gaide
Michal Koc
Syam Prakash Somasekharan
P2860cites workMembrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationQ24300125
Identification and characterization of a new member of the TNF family that induces apoptosisQ24318423
X-linked IAP is a direct inhibitor of cell-death proteasesQ24318710
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine familyQ24320301
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspasesQ24532851
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell deathQ24630370
Cell motility through plasma membrane blebbingQ24656957
TRAIL receptor-2 signals apoptosis through FADD and caspase-8Q28142998
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapyQ28176737
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbingQ28210013
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complexQ28221276
An antagonist decoy receptor and a death domain-containing receptor for TRAILQ28245153
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptorsQ28245164
Death receptors: signaling and modulationQ28280897
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.Q53426774
TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2.Q53501262
TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK PathwaysQ59225369
Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cellsQ59225404
Blebs lead the way: how to migrate without lamellipodiaQ28287258
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cellsQ30305481
Role of BAX in the apoptotic response to anticancer agentsQ31523620
Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivoQ33784712
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.Q33941102
Mitochondria as the central control point of apoptosisQ33994978
New insights into apoptosis signaling by Apo2L/TRAIL.Q34022690
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.Q34277650
Caspases in cell survival, proliferation and differentiation.Q34652977
Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC levelQ35051505
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapyQ35093740
Non-apoptotic functions of caspases in cellular proliferation and differentiationQ35557615
Collective cell migration in morphogenesis and cancerQ35878896
Mechanisms of cancer cell invasionQ36015535
Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy.Q36080043
Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapyQ36112074
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.Q36463059
Rho kinase in the regulation of cell death and survivalQ36755421
TRAIL signalling: decisions between life and death.Q36778214
The TRAIL apoptotic pathway in cancer onset, progression and therapyQ37278043
Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressionsQ39569903
Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosisQ39612127
Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosisQ39653516
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.Q39753656
Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through the ERK pathwayQ39961942
Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activationQ40361024
Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cellsQ40372744
Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cellsQ40414448
Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophilsQ40425494
Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cellsQ40604705
Actin-binding protein requirement for cortical stability and efficient locomotionQ41643536
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effectsQ42916419
Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activationQ43105405
Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cellsQ43902939
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Q43903493
Platelet formation is the consequence of caspase activation within megakaryocytesQ44083637
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.Q44482351
The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cellsQ44539646
Marginal blebbing during the early stages of TNF-induced apoptosis indicates alteration in actomyosin contractilityQ44955909
Caspase signalling controls microglia activation and neurotoxicity.Q53422658
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)324-336
P577publication date2013-03-01
P1433published inApoptosisQ15749546
P1476titleTRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis
P478volume18

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cites work (P2860)
Q38882537A fate worse than death: apoptosis as an oncogenic process
Q41083072An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity.
Q90241548Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy
Q37098808Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis
Q36352596Chemotherapy with ceramide in TNBC.
Q55042637Combined application of Embelin and tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and invasion in osteosarcoma cells via caspase-induced apoptosis.
Q53701901Developing TRAIL/TRAIL death receptor-based cancer therapies.
Q37706093TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress
Q30635379YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.

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